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pro vyhledávání: '"Julian Scott Northen"'
Autor:
Robin Marshall, Catherine Smyth, J. Alf Davis, Alasdair Garnett, Julian Scott Northen, John S. Carey, Stephen J. Byard, Urvish Pandya, Stephen John Martin, Antonio Codina, Gary Patrick Reid, John Mykytiuk, Sophie L. Berrell, Katherine Filer, Lesa Watson
Publikováno v:
Organic Process Research & Development. 23:762-770
This paper describes the process development conducted toward the multi-kilogram synthesis of a hemiadipic acid pro-drug of buprenorphine. The major challenges were to control the levels of the dibuprenorphine monoadipate impurity and to improve the