Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julian Reading"'
Autor:
Samir Rachid Zaim, Mark-Phillip Pebworth, Imran McGrath, Lauren Okada, Morgan Weiss, Julian Reading, Julie L. Czartoski, Troy R. Torgerson, M. Juliana McElrath, Thomas F. Bumol, Peter J. Skene, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) is being increasingly used to study gene regulation. However, major analytical gaps limit its utility in studying gene regulatory programs in complex diseas
Externí odkaz:
https://doaj.org/article/510a659dc6a34101b8936defcaa98168
Autor:
Suhas V. Vasaikar, Adam K. Savage, Qiuyu Gong, Elliott Swanson, Aarthi Talla, Cara Lord, Alexander T. Heubeck, Julian Reading, Lucas T. Graybuck, Paul Meijer, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively
Externí odkaz:
https://doaj.org/article/9167378588ad444cbf7f985a5e41ce2a
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Barcode-based multiplexing methods can be used to increase throughput and reduce batch effects in large single-cell genomics studies. Despite advantages in flexibility of sample collection and scale, there are additional complicat
Externí odkaz:
https://doaj.org/article/21179aa92949406b80b4c94dfe7b6c4c
Autor:
Palak C. Genge, Charles R. Roll, Alexander T. Heubeck, Elliott Swanson, Nina Kondza, Cara Lord, Morgan Weiss, Veronica Hernandez, Cole Phalen, Zachary Thomson, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Julian Reading
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100900- (2021)
Summary: Deep immune profiling is essential for understanding the human immune system in health and disease. Successful biological interpretation of this data requires consistent laboratory processing with minimal batch-to-batch variation. Here, we d
Externí odkaz:
https://doaj.org/article/fae212fe174d4a2a85ae33c7cb9322d0
Autor:
Elliott Swanson, Cara Lord, Julian Reading, Alexander T Heubeck, Palak C Genge, Zachary Thomson, Morgan DA Weiss, Xiao-jun Li, Adam K Savage, Richard R Green, Troy R Torgerson, Thomas F Bumol, Lucas T Graybuck, Peter J Skene
Publikováno v:
eLife, Vol 10 (2021)
Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation, cellular responses to signals, and human disease. Recent advances have allowed paired capture of prote
Externí odkaz:
https://doaj.org/article/046189b6ef98402f806f13d5a7619de7
Autor:
Alexander Heubeck, Adam Savage, Katherine Henderson, Charles Roll, Veronica Hernandez, Troy Torgerson, Thomas Bumol, Julian Reading
Publikováno v:
Cytometry Part A.
Autor:
Alexander, Heubeck, Adam, Savage, Katherine, Henderson, Charles, Roll, Veronica, Hernandez, Troy, Torgerson, Thomas, Bumol, Julian, Reading
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
Immunophenotyping using high dimensional flow cytometry is a central component of human immune system multi-omic studies. We present four high parameter flow cytometry panels for deep immunophenotyping of human peripheral blood mononuclear cells (PBM
Autor:
Suhas V. Vasaikar, Adam K. Savage, Qiuyu Gong, Elliott Swanson, Aarthi Talla, Cara Lord, Alexander T Heubeck, Julian Reading, Lucas T. Graybuck, Paul Meijer, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Xiao-jun Li
Longitudinal bulk and single-cell omics data is increasingly generated for biological and clinical research but is challenging to analyze due to its many intrinsic types of variations. We present PALMO (https://github.com/aifimmunology/PALMO), a plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8645e97c71067cfff8f489c387e499ce
https://doi.org/10.1101/2022.10.17.512585
https://doi.org/10.1101/2022.10.17.512585
Autor:
Claire E. Gustafson, Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth, Lauren Y. Okada, Alexander T. Heubeck, Charles R. Roll, Veronica Hernandez, Morgan Weiss, Palak C. Genge, Julian Reading, Josephine R. Giles, Sasikanth Manne, Jeanette Dougherty, CJ Jasen, Allison R. Greenplate, Lynne A. Becker, Lucas T. Graybuck, Suhas V. Vasaikar, Gregory L. Szeto, Adam K. Savage, Cate Speake, Jane H. Buckner, Xiao-jun Li, Troy R. Torgerson, E. John Wherry, Thomas F. Bumol, Laura A. Vella, Sarah E. Henrickson, Peter J. Skene
The naive T cell compartment undergoes multiple changes across age that associate with altered susceptibility to infection and autoimmunity. In addition to the acquisition of naive-like memory T cell subsets, mouse studies describe substantial molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510ab66e66b266ad28cf5b58559c3b29
https://doi.org/10.1101/2022.10.04.510869
https://doi.org/10.1101/2022.10.04.510869
Publikováno v:
BMC Bioinformatics. 23
Background Barcode-based multiplexing methods can be used to increase throughput and reduce batch effects in large single-cell genomics studies. Despite advantages in flexibility of sample collection and scale, there are additional complications in t