Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Julian R. A. Wooltorton"'
Autor:
Bert W. O'Malley, Daqing Li, Andrew Tsourkas, Mohammad N. Kayyali, Tiffany N. Chao, Andrew J. Ramsey, Julian R. A. Wooltorton, Mei Lin
Publikováno v:
Journal of Controlled Release. 279:243-250
Hearing loss is the most prevalent sensory disability worldwide and may be caused by age, drugs or exposure to excessive noise. We have previously developed a minimally-invasive nanohydrogel drug delivery system that successfully delivers nanoparticl
Autor:
Daniel J. Cavanaugh, James Eberwine, Xiangzhong Zheng, Jennifer M. Spaethling, Erik C. Johnson, Amita Sehgal, Clare E. Hector, Julian R. A. Wooltorton, Jill D. Geratowski
Publikováno v:
Cell. 157(3):689-701
SummaryThough much is known about the cellular and molecular components of the circadian clock, output pathways that couple clock cells to overt behaviors have not been identified. We conducted a screen for circadian-relevant neurons in the Drosophil
Autor:
Jelena Platisa, Vincent A. Pieribone, Lawrence B. Cohen, Zhou Han, Lei Jin, Julian R. A. Wooltorton
Publikováno v:
Neuron. 75:779-785
Monitoring neuronal electrical activity using fluorescent protein-based voltage sensors has been limited by small response magnitudes and slow kinetics of existing probes. Here we report the development of a novel fluorescent protein voltage sensor,
Autor:
Ruth Anne Eatock, Steven D. Price, Karen M. Hurley, Anna Lysakowski, Julian R. A. Wooltorton, Jasmine L. Garcia, Meng Zhong, Sophie Gaboyard
Publikováno v:
Journal of Neurophysiology. 97:1684-1704
Two kinds of sodium current ( INa) have been separately reported in hair cells of the immature rodent utricle, a vestibular organ. We show that rat utricular hair cells express one or the other current depending on age (between postnatal days 0 and 2
Autor:
Anna Lysakowski, Sophie Gaboyard-Niay, Xiao Ping Liu, Julian R. A. Wooltorton, Fu Chia Yang, Ruth Anne Eatock
Publikováno v:
Journal of neurophysiology. 115(5)
Firing patterns differ between subpopulations of vestibular primary afferent neurons. The role of sodium (NaV) channels in this diversity has not been investigated because NaV currents in rodent vestibular ganglion neurons (VGNs) were reported to be
Publikováno v:
The Journal of Neuroscience. 23:3176-3185
Although many psychopharmacological factors contribute to nicotine addiction, midbrain dopaminergic systems have received much attention because of their roles in reinforcement and associative learning. It is generally thought that the mesocorticolim
Publikováno v:
European Journal of Neuroscience. 9:2225-2235
Gamma-Aminobutyric acid (GABA[A]) receptor beta3 subunits were expressed in Xenopus laevis oocytes and studied using two-electrode voltage clamp. Injected oocytes exhibited an increased resting membrane conductance and more depolarized membrane poten
Publikováno v:
Proceedings of the National Academy of Sciences. 93:9899-9904
gamma-aminobutyric acid type A (GABAA) receptors are the major sites of fast synaptic inhibition in the brain. They are constructed from four subunit classes with multiple members: alpha (1-6), beta (1-4), gamma (1-4), and delta (1). The contribution
Publikováno v:
British Journal of Pharmacology. 116:2191-2200
1. The block of K+ currents by amitriptyline and the related tricyclic compounds cyproheptadine and dizocilpine was studied in dissociated rat sympathetic neurones by whole-cell voltage-clamp recording. 2. Cyproheptadine (30 microM) inhibited the del