Výsledky vyhledávání - "Julian R Homburger"

Akademický článek

Genomic Insights into the Ancestry and Demographic History of South America.

Autor: Julian R Homburger, Andrés Moreno-Estrada, Christopher R Gignoux, Dominic Nelson, Elena Sanchez, Patricia Ortiz-Tello, Bernardo A Pons-Estel, Eduardo Acevedo-Vasquez, Pedro Miranda, Carl D Langefeld, Simon Gravel, Marta E Alarcón-Riquelme, Carlos D Bustamante

Publikováno v: PLoS Genetics, Vol 11, Iss 12, p e1005602 (2015)

South America has a complex demographic history shaped by multiple migration and admixture events in pre- and post-colonial times. Settled over 14,000 years ago by Native Americans, South America has experienced migrations of European and African ind

Externí odkaz: https://doaj.org/article/13ea7e55e3c143a6b66b487d01f1a7f9

Zobrazit plný text záznamu

Akademický článek

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

Autor: Akl C. Fahed, Minxian Wang, Julian R. Homburger, Aniruddh P. Patel, Alexander G. Bick, Cynthia L. Neben, Carmen Lai, Deanna Brockman, Anthony Philippakis, Patrick T. Ellinor, Christopher A. Cassa, Matthew Lebo, Kenney Ng, Eric S. Lander, Alicia Y. Zhou, Sekar Kathiresan, Amit V. Khera

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Genetic variation predisposes to disease via monogenic and polygenic risk variants. Here, the authors assess the interplay between these types of variation on disease penetrance in 80,928 individuals. In carriers of monogenic variants, they show that

Externí odkaz: https://doaj.org/article/accfd73a30f24117b30c06b2df4acd2d

Zobrazit plný text záznamu

Machine learning enables new insights into genetic contributions to liver fat accumulation

Autor: Mary E. Haas, James P. Pirruccello, Samuel N. Friedman, Minxian Wang, Connor A. Emdin, Veeral H. Ajmera, Tracey G. Simon, Julian R. Homburger, Xiuqing Guo, Matthew Budoff, Kathleen E. Corey, Alicia Y. Zhou, Anthony Philippakis, Patrick T. Ellinor, Rohit Loomba, Puneet Batra, Amit V. Khera

Publikováno v: Cell genomics, vol 1, iss 3
Cell Genom

Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease and cardiometabolic diseases but often remains undiagnosed in clinical practice because of the need for direct imaging assessments. We developed an abdom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474b5aaf8ae24c8e6b3e0209996a8c2
https://escholarship.org/uc/item/4gn3z7cs

Zobrazit plný text záznamu

Model-driven mitigation measures for reopening schools during the COVID-19 pandemic

Autor: Carl T. Bergstrom, Hannah E. Williams, Ryan Seamus McGee, Alicia Y. Zhou, Julian R. Homburger

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance As the COVID-19 pandemic drags on, we need strategies for reopening those schools that have remained closed. We developed stochastic network models to study the risks associated with returning to in-person learning during the COVID-19 pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26479190ff7d28ca32cc90d02b0b48f
https://doi.org/10.1073/pnas.2108909118

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání