Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Julian R E Davis"'
Autor:
Hiroshi Momiji, Kirsty L Hassall, Karen Featherstone, Anne V McNamara, Amanda L Patist, David G Spiller, Helen C Christian, Michael R H White, Julian R E Davis, Bärbel F Finkenstädt, David A Rand
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007030 (2019)
Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator. Despite its physiological importance, the cell-level mechanisms of prolactin production are not well understood. Having significantly improved the resolutio
Externí odkaz:
https://doaj.org/article/2bbb8bc2d77d4092b761e5d67d0c979f
Autor:
Claire V Harper, Bärbel Finkenstädt, Dan J Woodcock, Sönke Friedrichsen, Sabrina Semprini, Louise Ashall, David G Spiller, John J Mullins, David A Rand, Julian R E Davis, Michael R H White
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1000607 (2011)
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses. To investigate the origins of this behavior and to understand its functional relevance, we
Externí odkaz:
https://doaj.org/article/188cf6c3240644bba2dec08fe24b29a3
Autor:
Adrian H. Heald, Andreas Walther, Julian R. E. Davis, Gabriela Y. C. Moreno, John Kane, Mark Livingston, Helen L. Fowler
Publikováno v:
Frontiers in Psychology, Vol 8 (2017)
Patients with Addison’s disease have relatively high rates of depression and anxiety symptoms compared with population-based reference samples. Addison’s disease results in deficiency of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S). Th
Externí odkaz:
https://doaj.org/article/4b28b115f16c4c7fa24aae765de36601
Autor:
Michael R. H. White, Sabrina Semprini, Claire V. Harper, Nicholas Jones, David G. Spiller, Karen Featherstone, Anne V McNamara, Antony A Adamson, Hiroshi Momiji, Bärbel Finkenstädt, John J. Mullins, Lee M. Dunham, David A. Rand, Raheela Awais, Julian R. E. Davis
Publikováno v:
Endocrinology
McNamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology, vol. 162, no. 4, bqaa249 . https://doi.org/10.1210/endocr/bqaa249
Mcnamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology . https://doi.org/10.1210/endocr/bqaa249
McNamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology, vol. 162, no. 4, bqaa249 . https://doi.org/10.1210/endocr/bqaa249
Mcnamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology . https://doi.org/10.1210/endocr/bqaa249
Gene transcription occurs in short bursts interspersed with silent periods, and these kinetics can be altered by promoter structure. The effect of alternate promoter architecture on transcription bursting is not known. We studied the human prolactin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3d33d6a6a1eeac0e7aa4fe834e169c
http://wrap.warwick.ac.uk/146862/7/WRAP-Transcription-factor-Pit-1-affects-transcriptional-timing-dual-promoter-human-prolactin-gene-Rand-2021.pdf
http://wrap.warwick.ac.uk/146862/7/WRAP-Transcription-factor-Pit-1-affects-transcriptional-timing-dual-promoter-human-prolactin-gene-Rand-2021.pdf
Autor:
Claire V. Harper, Jayne C Charnock, Anne V McNamara, David G. Spiller, Julian R. E. Davis, Michael R. H. White
Publikováno v:
Journal of Molecular Endocrinology
Pituitary cells have been reported to show spontaneous calcium oscillations and dynamic transcription cycles. To study both processes in the same living cell in real time, we used rat pituitary GH3 cells stably expressing human prolactin-luciferase o
Autor:
Federico Roncaroli, Yi Yuen Wang, Carmela Caputo, Peter J Trainer, Mueez Waqar, Julian R. E. Davis, Tara Kearney, A. Abou-Zeid, Claire E Higham, Kanna K. Gnanalingham
Publikováno v:
Wang, Y Y, Waqar, M, Abou-Zeid, A, Kearney, T, Caputo, C, Davis, J, Trainer, P, Higham, C, Roncaroli, F & Gnanalingham, K K 2021, ' Value of early post-operative growth hormone testing in predicting long-term remission and residual disease after transsphenoidal surgery for Acromegaly ', Neuroendocrinology . https://doi.org/10.1159/000517476
Introduction: Surgical remission for acromegaly is dependent on a number of factors including tumour size, invasiveness, and surgical expertise. We studied the value of early post-operative growth hormone (GH) level as a predictor of outcome and to g
Autor:
Julian R. E. Davis, Bridget Young, Paul Dimitri, Peter Callery, Jennifer Downing, Peter E. Clayton, Jerry Wales, Helena Gleeson
Publikováno v:
BMC Endocrine Disorders, Vol 17, Iss 1, Pp 1-9 (2017)
Callery, P, Clayton, P, Davis, J, Downing, J, Young, B, Dimitri, P, Gleeson, H & Wales, J 2017, ' Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study ', BMC Endocrine Disorders, vol. 17, no. 33 . https://doi.org/10.1186/s12902-017-0182-6
BMC ENDOCRINE DISORDERS
BMC Endocrine Disorders
Callery, P, Clayton, P, Davis, J, Downing, J, Young, B, Dimitri, P, Gleeson, H & Wales, J 2017, ' Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study ', BMC Endocrine Disorders, vol. 17, no. 33 . https://doi.org/10.1186/s12902-017-0182-6
BMC ENDOCRINE DISORDERS
BMC Endocrine Disorders
BackgroundCommunication is complex in endocrine care, particularly during transition from paediatric to adult services. The aims of this study were to examine the feasibility of interventions to support young people to interact with clinicians.Method
Autor:
Sabrina Semprini, Antony Adamson, Anne V McNamara, John J. Mullins, Michael R. H. White, Julian R. E. Davis, David G. Spiller, Lee S. S. Dunham, Alan S. McNeilly
Publikováno v:
Molecular Endocrinology
McNamara, A V, Adamson, A D, Dunham, L S S, Semprini, S, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2016, ' Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing ', Molecular Endocrinology, vol. 30, no. 2, pp. 189-200 . https://doi.org/10.1210/me.2015-1186
Mcnamara, A, Adamson, A, Dunham, L, Semprini, S, Spiller, D, McNeilly, A S, Mullins, J J, Davis, JRE & White, M 2016, ' Role of estrogen response element in the human prolactin gene: transcriptional response and timing ', Molecular Endocrinology, vol. 30, no. 2 . https://doi.org/10.1210/me.2015-1186
McNamara, A V, Adamson, A D, Dunham, L S S, Semprini, S, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2016, ' Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing ', Molecular Endocrinology, vol. 30, no. 2, pp. 189-200 . https://doi.org/10.1210/me.2015-1186
Mcnamara, A, Adamson, A, Dunham, L, Semprini, S, Spiller, D, McNeilly, A S, Mullins, J J, Davis, JRE & White, M 2016, ' Role of estrogen response element in the human prolactin gene: transcriptional response and timing ', Molecular Endocrinology, vol. 30, no. 2 . https://doi.org/10.1210/me.2015-1186
The use of bacterial artificial chromosome (BAC) reporter constructs in molecular physiology enables the inclusion of large sections of flanking DNA, likely to contain regulatory elements and enhancers regions that contribute to the transcriptional o
Autor:
Alexander C. West, Le Yu, David W. Burt, Julian R. E. Davis, Alan S. McNeilly, Sandrine M. Dupre, I.R. Paton, Katarzyna Miedzinska, Andrew S. I. Loudon
Publikováno v:
West, A, Dupre, S, Yu, L, Paton, B, Miedzinska, K, McNeilly, A, Davis, J, Burt, D & Loudon, A 2013, ' Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis ', Molecular Endocrinology, vol. 27, no. 6, pp. 979-989 . https://doi.org/10.1210/me.2012-1366
Molecular Endocrinology
Molecular Endocrinology
Seasonal mammals integrate changes in the duration of nocturnal melatonin secretion to drive annual physiologic cycles. Melatonin receptors within the proximal pituitary region, the pars tuberalis (PT), are essential in regulating seasonal neuroendoc
Autor:
Jerry Wales, Helena Gleeson, Julian R. E. Davis, Peter Callery, Jennifer Downing, Peter E. Clayton
Publikováno v:
Clinical Endocrinology. 78:29-35
OBJECTIVE: Transition from child to adult status is a crucial stage in young people's lives. It is important that young people continue to receive appropriate endocrine care throughout and following transfer from paediatric to adult services. This st