Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julian P. Layer"'
Autor:
Frank A. Giordano, Julian P. Layer, Sonia Leonardelli, Lea L. Friker, Roberta Turiello, Dillon Corvino, Thomas Zeyen, Christina Schaub, Wolf Müller, Elena Sperk, Leonard Christopher Schmeel, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Torsten Pietsch, Sotirios Bisdas, Michael Platten, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT) by facilitating vasculogenesis. Here we report outcomes of the dose-escalation part of GLORIA (NCT04121455), a phase I/II trial combining RT and the CXCL12-n
Externí odkaz:
https://doaj.org/article/a461b70c215e421cabb2b9a14f5dfb4b
Autor:
Molina Grimmer, MSc, Gustavo R. Sarria, MD, Motaz Hamed, MD, Mohammed Banat, MD, Fabian Kugel, MSc, Hector Lorenzana, MHA, Davide Scafa, MD, Mümtaz Köksal, MD, Julian P. Layer, MD, Cas Dejonckheere, MD, Martin Fiebich, PhD, Frederic Carsten Schmeel, MD, Ana Kowark, MD, Hartmut Vatter, PhD, Leonard Christopher Schmeel, MD, Stephan Garbe, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 9, Iss 5, Pp 101466- (2024)
Purpose: A correct placement of the applicator during intraoperative radiation therapy for brain metastasis is of paramount importance, to deliver a precise and safe treatment. The applicator-to-surface contact assessment cannot be performed under di
Externí odkaz:
https://doaj.org/article/b3be792e130e4d60bc5e06a1aaa5e127
Autor:
Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Röhner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Leonard Christopher Schmeel
Publikováno v:
Current Oncology, Vol 30, Iss 2, Pp 1300-1313 (2023)
Purpose: To determine the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM), either as a definitive or adjuvant treatment. Methods: We assessed clinical data of patients receiving five fractions of
Externí odkaz:
https://doaj.org/article/14acb167281c4e949dff21e05e773afc
Autor:
Julian P. Layer, Marie T. Kronmüller, Thomas Quast, Debby van den Boorn-Konijnenberg, Maike Effern, Daniel Hinze, Kristina Althoff, Alexander Schramm, Frank Westermann, Martin Peifer, Gunther Hartmann, Thomas Tüting, Waldemar Kolanus, Matthias Fischer, Johannes Schulte, Michael Hölzel
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load
Externí odkaz:
https://doaj.org/article/555e23614fd84c37a22250949f85dd1a
Autor:
Nika Guberina, Florian Padeberg, Christoph Pöttgen, Maja Guberina, Lazaros Lazaridis, Ramazan Jabbarli, Cornelius Deuschl, Ken Herrmann, Tobias Blau, Karsten H. Wrede, Kathy Keyvani, Björn Scheffler, Jörg Hense, Julian P. Layer, Martin Glas, Ulrich Sure, Martin Stuschke
Publikováno v:
Cancers; Volume 15; Issue 11; Pages: 2982
Background: While prognosis of glioblastoma after trimodality treatment is well examined, recurrence pattern with respect to the delivered dose distribution is less well described. Therefore, here we examine the gain of additional margins around the
Autor:
Clemens Seidel, Katharina Sahm, Thomas Zeyen, Sotirios Bisdas, Frank A. Giordano, Elena Sperk, Sied Kebir, Julian P Layer, Ulrich Herrlinger, Sonia Leonardelli, Martin Glas, Lea Friker, Torsten Pietsch, Christina Schaub, Peter Hambsch, Michael Hölzel
Publikováno v:
Neuro Oncol
BACKGROUND Preclinical studies showed that CXCL12-mediated influx of highly angiogenic monocytes/macrophages is a key driver of tumor re-vascularization and re-growth after radiotherapy (RT) of glioblastoma (GBM). We report findings from a phase I/II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e295cf828fb360634306c6dddeec1c
Autor:
Motaz Hamed, Anna-Laura Potthoff, Julian P. Layer, David Koch, Valeri Borger, Muriel Heimann, Davide Scafa, Gustavo R. Sarria, Jasmin A. Holz, Frederic Carsten Schmeel, Alexander Radbruch, Erdem Güresir, Niklas Schäfer, Patrick Schuss, Stephan Garbe, Frank A. Giordano, Ulrich Herrlinger, Hartmut Vatter, Leonard Christopher Schmeel, Matthias Schneider
Publikováno v:
Cancers; Volume 14; Issue 6; Pages: 1515
Intraoperative radiotherapy (IORT) of the operative cavity for surgically treated brain metastasis (BM) has gained increasing prominence with respect to improved local tumor control. However, IORT immediately performed at the time of surgery might be
Autor:
Kritika Saraf, Dillon Corvino, Julian P Layer, Johanna A Seier, Julia Reinhardt, Kristina Althoff, Frank A. Giordano, Alexander Schramm, Michael Hölzel, Susanna S. Ng, Matthias Fischer
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
BackgroundAmplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system. There is evidence that MYCN promotes a non-inflamed and T-cell infiltration-poor (‘cold’)
Autor:
Matthias Fischer, Johannes H. Schulte, Debby van den Boorn-Konijnenberg, Martin Peifer, Thomas Quast, Michael Hölzel, Gunther Hartmann, Maike Effern, Alexander Schramm, Julian P. Layer, Daniel Hinze, Frank Westermann, Waldemar Kolanus, Marie T. Kronmüller, Kristina Althoff, Thomas Tüting
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dc9e78ee3c754fa7296c479a883618
http://europepmc.org/articles/pmc5486176
http://europepmc.org/articles/pmc5486176
Autor:
Cas Stefaan Dejonckheere, Egon Dejonckheere, Julian Philipp Layer, Katharina Layer, Gustavo Renato Sarria, David Koch, Alina Abramian, Christina Kaiser, Kira Lindner, Anne Bachmann, Teresa Anzböck, Fred Röhner, Frederic Carsten Schmeel, Leonard Christopher Schmeel
Publikováno v:
Breast, Vol 71, Iss , Pp 31-41 (2023)
Purpose: Radiation dermatitis (RD) is the most common side effect of adjuvant whole-breast or chest wall irradiation, majorly impacting quality of life in numerous patients. The use of barrier films (polyurethane dressings such as Hydrofilm® and Mep
Externí odkaz:
https://doaj.org/article/472ce974562342b79e858350aac24563