Výsledky vyhledávání - "Julian P Venables"

Akademický článek

Neural differentiation modulates the vertebrate brain specific splicing program.

Autor: Alicia Madgwick, Philippe Fort, Peter S Hanson, Philippe Thibault, Marie-Claude Gaudreau, Georges Lutfalla, Tarik Möröy, Sherif Abou Elela, Bill Chaudhry, David J Elliott, Christopher M Morris, Julian P Venables

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125998 (2015)

Alternative splicing patterns are known to vary between tissues but these patterns have been found to be predominantly peculiar to one species or another, implying only a limited function in fundamental neural biology. Here we used high-throughput RT

Externí odkaz: https://doaj.org/article/78273da63e0c42d6b4254c62defbdd13

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Akademický článek

The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain.

Autor: Ingrid Ehrmann, Caroline Dalgliesh, Yilei Liu, Marina Danilenko, Moira Crosier, Lynn Overman, Helen M Arthur, Susan Lindsay, Gavin J Clowry, Julian P Venables, Philippe Fort, David J Elliott

Publikováno v: PLoS Genetics, Vol 9, Iss 4, p e1003474 (2013)

The RNA binding protein T-STAR was created following a gene triplication 520-610 million years ago, which also produced its two parologs Sam68 and SLM-1. Here we have created a T-STAR null mouse to identify the endogenous functions of this RNA bindin

Externí odkaz: https://doaj.org/article/f864fa3a2be147ddafb7de7d8ed2a028

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Akademický článek

Atypical haemolytic uraemic syndrome associated with a hybrid complement gene.

Autor: Julian P Venables, Lisa Strain, Danny Routledge, David Bourn, Helen M Powell, Paul Warwicker, Martha L Diaz-Torres, Anne Sampson, Paul Mead, Michelle Webb, Yves Pirson, Michael S Jackson, Anne Hughes, Katrina M Wood, Judith A Goodship, Timothy H J Goodship

Publikováno v: PLoS Medicine, Vol 3, Iss 10, p e431 (2006)

BACKGROUND: Sequence analysis of the regulators of complement activation (RCA) cluster of genes at chromosome position 1q32 shows evidence of several large genomic duplications. These duplications have resulted in a high degree of sequence identity b

Externí odkaz: https://doaj.org/article/209c2f92f798427db3774ee714ab993d

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Akademický článek

SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

Autor: Kazuhiro Fukumura, Julian P. Venables, Akila Mayeda

Publikováno v: Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to var

Externí odkaz: https://doaj.org/article/96b50050e32241f9accc7addc7851d82

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