Výsledky vyhledávání - "Julian M. Marshall"

The domain organization of streptokinase: Nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments

Autor: Francisco Conejero-Lara, Juan Parrado, Chris P. Ponting, Christopher M. Dobson, Julian M. Marshall, Richard Smith

Publikováno v: Protein Science. 5:693-704

Streptococcus equisimilis streptokinase (SK) is a bacterial protein of unknown tertiary structure and domain organization that is used extensively to treat acute myocardial infarction following coronary thrombosis. Six fragments of SK were generated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6517c6d32fad9bba8824699870fe7214
https://doi.org/10.1002/pro.5560050414

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Plasminogen activators in ectopic and uterine endometrium

Autor: P.M. Starkey, Bev Hicks, Julian M. Marshall, Sylvia Fernandez-Shaw, David H. Barlow

Publikováno v: Fertility and Sterility. 63:45-51

Objective To investigate the expression of the plasminogen activator (PA)-plasmin system components in ectopic endometrium and in uterine endometrium from women with and without endometriosis. Design Plasminogen, PAs (urokinase and tissue plasminogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cf9a5e827f55313bda48b65e347ee8
https://doi.org/10.1016/s0015-0282(16)57295-1

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Conformational Studies of Human Plasminogen and Plasminogen Fragments: Evidence for a Novel Third Conformation of Plasminogen

Autor: Adrian J. Brown, Julian M. Marshall, Chris P. Ponting

Publikováno v: Biochemistry. 33:3599-3606

The conformations of Glu-plasminogen and defined proteolytic fragments, in the presence and absence of 6-aminohexanoic acid (6-AHA), trans-4-(aminomethyl)cyclohexanecarboxylic acid (t-AMCHA), and benzamidine, were studied using three methods: size-ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18344fdab80c7cac736c502e87e438c
https://doi.org/10.1021/bi00178a017

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Plasminogen

Autor: Stewart A. Cederholm-Williams, Julian M. Marshall, Chris P. Ponting

Publikováno v: Blood Coagulation & Fibrinolysis. 3:605-614

Plasminogen is the zymogen form of plasmin, a broad specificity serine protease whose activity contributes to a variety of normal and pathological conditions, including intravascular thrombolysis and extracellular proteolysis. Plasminogen contains se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c98801d17ea7e17d609c21c6c0fb0a
https://doi.org/10.1097/00001721-199210000-00012

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A comparative analysis of two preparations of human chorionic gonadotrophin

Autor: Stuart A. Cederholm Williams, Robert G. Forman, Julian N. Robinson, Julian M. Marshall

Publikováno v: European Journal of Obstetrics & Gynecology and Reproductive Biology. 46:123-127

A biophysical analysis of two pharmaceutical preparations of human chorionic gonadotrophin (Endo and Profasi) demonstrated that both contained high hCG specific activity. HCG protein analysis by occlusion HPLC and SDS gel electrophoresis showed simil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38806a082b63b46615f4d78b059e44a
https://doi.org/10.1016/0028-2243(92)90256-x

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Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide

Autor: Stewart A. Cederholm-Williams, Keith Martyn Dawson, Chris P. Ponting, Charles S. Cockell, Julian M. Marshall

Human Glu-plasminogen adopts at least three conformations that provide a means for regulating the specificity of its activation in vivo. It has been proposed previously that the closed (α) conformation of human Glu-plasminogen is maintained through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c93c2ccf60f2950fd2103130ac0878
https://europepmc.org/articles/PMC1219561/

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Substitution of arginine 719 for glutamic acid in human plasminogen substantially reduces its affinity for streptokinase

Autor: Keith Martyn Dawson, Julian M. Marshall, Richard James Gilbert, Robert H. Raper, Chris P. Ponting

Publikováno v: Biochemistry. 33(40)

In isolation human plasminogen possesses no enzymatic activity, yet upon formation of an equimolar complex with the bacterial protein streptokinase, it acquires a plasminogen activator function. The region(s) of plasminogen and of streptokinase which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215af9dcbdeb28e3bca6c357cc5fa908
https://pubmed.ncbi.nlm.nih.gov/7918423

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Glycoprotein glycosylation and the immunosuppressive effects of human pregnancy serum

Autor: Christopher W.G. Redman, Raymond A. Dwek, Thomas W. Rademacher, Peter D. Arkwright, Julian M. Marshall

Publikováno v: Journal of reproductive immunology. 21(1)

Pregnancy serum contains a factor or factors which suppress T lymphocyte proliferation, although the identity of the factor(s) is still unclear. We have demonstrated that the immunosuppressive activity of pregnancy sera can be destroyed by treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73917a6f0e04837f805bd588f98a77f8
https://pubmed.ncbi.nlm.nih.gov/1310337

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