Causal Analysis of Physiological Sleep Data Using Granger Causality and Score-Based Structure Learning

Autor: Alex Thomas, Mahesan Niranjan, Julian Legg

Publikováno v: Sensors, Vol 23, Iss 23, p 9455 (2023)

Understanding how the human body works during sleep and how this varies in the population is a task with significant implications for medicine. Polysomnographic studies, or sleep studies, are a common diagnostic method that produces a significant qua

Externí odkaz: https://doaj.org/article/b32aa1cf97af49b5958276b8ac087d21

COVID‐19: Impact, experiences, and support needs of children and young adults with cystic fibrosis and parents

Autor: Anna Campion, Anne-Sophie Darlington, Nicole Collaço, Carolyn West, Julian Legg, Maria Day, David Culliford

Publikováno v: Pediatric Pulmonology

Background: Little is known about the impact of COVID-19 and the United Kingdom's (UK) national shielding advice on people with cystic fibrosis (CF) and their families. This study explored the experiences and support needs of children and young adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439add1fb8b5ac792560a2023652603a
https://doi.org/10.1002/ppul.25537

Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR : a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial

Autor: Sivagurunathan Sutharsan, Edward F McKone, Damian G Downey, Jamie Duckers, Gordon MacGregor, Elizabeth Tullis, Eva Van Braeckel, Claire E Wainwright, Danie Watson, Neil Ahluwalia, Bote G Bruinsma, Christopher Harris, Anna P Lam, Yiyue Lou, Samuel M Moskowitz, Simon Tian, Jason Yuan, David Waltz, Marcus A Mall, Paul Aurora, Stijn Verhulst, Michael Lorenz, Jobst Roehmel, Wolfgang Gleiber, Susanne Naehrig, Florian Stehling, Silke van Koningsbruggen-Rietschel, Rainald Fischer, Damian Downey, Charles Haworth, Julian Legg, Peter Barry, Rebecca Thursfield, Simon James Doe, Tom Hilliard, Edward F Nash, Nicholas John Withers, Daniel Peckham, Helen Louise Barr, Timothy Lee, Robert Gray, Francois Vermeulen, Eef Vanderhelst, Philip J Robinson, Daniel J Smith, Siobhain A Mulrennan, Barry S Clements, Peter Wark

Publikováno v: VX18-445-109 study group 2021, ' Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial ', The Lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(21)00454-9

BackgroundElexacaftor plus tezacaftor plus ivacaftor is a triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator regimen shown to be generally safe and efficacious in people with cystic fibrosis aged 12 years or older

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c34a7aa3d2d4d1a01b05a402f021fc
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85124502293

1161 Improving the care of children presenting to the emergency department (ED) with a wheeze exacerbation- a quality improvement programme

Autor: Jemma Shanley, Krishna Patel, David James, Julian Legg

Publikováno v: Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98e88707e2409a86712eeee2c6145652
https://doi.org/10.1136/archdischild-2021-rcpch.443

A public health emergency among young people

Autor: Simon C Langton Hewer, Jonathan Grigg, Andrew Bush, Gary J Connett, Ian Sinha, Iolo Doull, Warren Lenney, Julian Legg, Francis J Gilchrist, Jayesh M. Bhatt

Publikováno v: The Lancet. Respiratory medicine. 8(3)

While some countries have banned the use of e-cigarettes or vaping products altogether (eg, India), and others have strongly advised against their use (eg, Australia), in the UK, Public Health England (PHE) appears to be a lone voice in stating that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b298e75c83951fe34605e87780b180f
https://pubmed.ncbi.nlm.nih.gov/31843487