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pro vyhledávání: '"Julian Leefmann"'
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Metabolic diseases and diabetes represent an increasing global challenge for human health care. As associated with a strongly elevated risk of developing atherosclerosis, kidney failure and death from myocardial infarction or stroke, the treatment of
Externí odkaz:
https://doaj.org/article/aa4fbc2612d84b18ac117e2bf7b9ba49
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 146:552-558
Publikováno v:
Deutsche medizinische Wochenschrift (1946). 146(8)
ATP-Citrate-Lyase is a key enzyme of cholesterol biosynthesis. Its liver-specific inhibition by the bempedoic acid opens new possibilities to effectively escalate a cholesterol-lowering therapy while avoiding muscle-related side effects. Herein, we p