Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Julian L Goggi"'
Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya
Autor:
Fok-Moon Lum, Yi-Hao Chan, Teck-Hui Teo, Etienne Becht, Siti Naqiah Amrun, Karen WW Teng, Siddesh V Hartimath, Nicholas KW Yeo, Wearn-Xin Yee, Nicholas Ang, Anthony M Torres-Ruesta, Siew-Wai Fong, Julian L Goggi, Evan W Newell, Laurent Renia, Guillaume Carissimo, Lisa FP Ng
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 641-663 (2024)
Abstract Communications between immune cells are essential to ensure appropriate coordination of their activities. Here, we observed the infiltration of activated macrophages into the joint-footpads of chikungunya virus (CHIKV)-infected animals. Larg
Externí odkaz:
https://doaj.org/article/c0fe0f20a551413cb93e952b39752db9
Autor:
Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K. Luthra, William D. Shingleton, Steve K. W. Oh, Li Zeng, Edward G. Robins
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Background Significant developments in stem cell therapy for Parkinson’s disease (PD) have already been achieved; however, methods for reliable assessment of dopamine neuron maturation in vivo are lacking. Establishing the efficacy of new
Externí odkaz:
https://doaj.org/article/7b3a51c8d38643008824b7f536251784
Autor:
Julian L. Goggi, Shivashankar Khanapur, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Hui-Xian Chin, Jun-Rong Tang, You-Yi Hwang, Edward G. Robins
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2343 (2022)
Often, patients fail to respond to immune checkpoint inhibitor (ICI) treatment despite favourable biomarker status. Numerous chemotherapeutic agents have been shown to promote tumour immunogenicity when used in conjunction with ICIs; however, little
Externí odkaz:
https://doaj.org/article/507bd3a96cca40bfacbd25567b24f5b3
Autor:
Julian L. Goggi, Boominathan Ramasamy, Yun Xuan Tan, Siddesh V. Hartimath, Jun Rong Tang, Peter Cheng, Rasha Msallam, Ann-Marie Chacko, You Yi Hwang, Edward G. Robins
Publikováno v:
Molecular Imaging, Vol 2021 (2021)
Hepatocellular carcinoma (HCC) is a notoriously difficult cancer to treat. The recent development of immune checkpoint inhibitors has revolutionised HCC therapy; however, successful response is only observed in a small percentage of patients. Biomark
Externí odkaz:
https://doaj.org/article/80a593fefbf7406eb9f2970c1f86d7e6
Autor:
Ivo J. H. M. de Vos, Arnette Shi Wei Wong, Jason Taslim, Sheena Li Ming Ong, Nicole C. Syder, Julian L. Goggi, Thomas J. Carney, Maurice A. M. van Steensel
Publikováno v:
Biology Open, Vol 9, Iss 12 (2020)
Frank-Ter Haar syndrome (FTHS, MIM #249420) is a rare skeletal dysplasia within the defective collagen remodelling spectrum (DECORS), which is characterised by craniofacial abnormalities, skeletal malformations and fibrotic soft tissues changes inclu
Externí odkaz:
https://doaj.org/article/fbf0145d5183405281f6adafd7b26f1b
Autor:
Julian L. Goggi, Shivashankar Khanapur, Boominathan Ramasamy, Siddesh V. Hartimath, Tang Jun Rong, Peter Cheng, Yun Xuan Tan, Xin Yi Yeo, Sangyong Jung, Stephanie Shee Min Goay, Seow Theng Ong, You Yi Hwang, K. George Chandy, Edward G. Robins
Publikováno v:
Cancers, Vol 14, Iss 5, p 1217 (2022)
Immune checkpoint inhibitors have shown great promise, emerging as a new pillar of treatment for cancer; however, only a relatively small proportion of recipients show a durable response to treatment. Strategies that reliably differentiate durably-re
Externí odkaz:
https://doaj.org/article/10427aba14f846449f2582059c328cbe
Autor:
Siddesh V. Hartimath, Boominathan Ramasamy, Tan Yun Xuan, Tang Jun Rong, Shivashankar Khanapur, Peter Cheng, You Yi Hwang, Edward G. Robins, Julian L. Goggi
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 150 (2022)
Immune checkpoint inhibitors (ICIs) block checkpoint receptors that tumours use for immune evasion, allowing immune cells to target and destroy cancer cells. Despite rapid advancements in immunotherapy, durable response rates to ICIs remains low. To
Externí odkaz:
https://doaj.org/article/9db5ad1621d3485cb8e454fb4af6b0f0
Publikováno v:
Biology Open, Vol 9, Iss 5 (2020)
Reissner fibre (RF), discovered by the 19th-century German anatomist Ernst Reissner, is a filamentous structure present in cerebrospinal fluid (CSF). RF forms by aggregation of a glycoprotein called SCO-spondin (Sspo), but its function has remained e
Externí odkaz:
https://doaj.org/article/0b2bf724882c4623850de18c4e9d76c8
Autor:
Yi-Hao Chan, Teck-Hui Teo, Anthony Torres-Ruesta, Siddesh V. Hartimath, Rhonda Sin-Ling Chee, Shivashankar Khanapur, Fui Fong Yong, Boominathan Ramasamy, Peter Cheng, Ravisankar Rajarethinam, Edward G. Robins, Julian L. Goggi, Fok-Moon Lum, Guillaume Carissimo, Laurent Rénia, Lisa F. P. Ng
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
O'nyong-nyong virus (ONNV) is an arthritogenic alphavirus that caused two large epidemics in 1959 and 1996, affecting millions of people in Africa. More recently, sero-surveillance of healthy blood donors conducted in 2019 revealed high rates of unre
Externí odkaz:
https://doaj.org/article/934e388fe2504d76ab72f450dfa1a577
Autor:
Xin Hui Derryn Chan, Ghayathri Balasundaram, Amalina Binte Ebrahim Attia, Julian L. Goggi, Boominathan Ramasamy, Weiping Han, Malini Olivo, Shigeki Sugii
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 1071-1078 (2018)
The discovery that white adipocytes can undergo a browning process to become metabolically active beige cells has attracted significant interest in the fight against obesity. However, the study of adipose browning has been impeded by a lack of imagin
Externí odkaz:
https://doaj.org/article/cd25df4540234ca38d6e67241ad231b3