Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Julian K Christians"'
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296853 (2024)
BackgroundIt is hypothesized that male fetuses prioritize growth, resulting in increased mortality, whereas females reduce growth in the presence of adversity. Preeclampsia reflects a chronic condition, in which fetuses have the opportunity to adjust
Externí odkaz:
https://doaj.org/article/b1d0f56e6eee4c18b7f3b12445945da1
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0256906 (2021)
BackgroundLactation results in substantial maternal bone loss that is recovered following weaning. However, the mechanisms underlying this recovery, and in particular the role of insulin-like growth factor 1 (IGF-I), is not clear. Furthermore, there
Externí odkaz:
https://doaj.org/article/ced86559f02a4d56b54ca3a82a1c77e0
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228664 (2020)
BACKGROUND:Spontaneous abortions, intrauterine growth restriction, and preeclampsia are thought to be caused by defective placentation and are associated with increased risk of adverse outcomes in subsequent pregnancies. However, it is not known whet
Externí odkaz:
https://doaj.org/article/df5187fa6e084ecebf0c1787b8e4879d
Autor:
Eunice H Chin, Kim L Schmidt, Kaitlyn M Martel, Chi Kin Wong, Jordan E Hamden, William T Gibson, Kiran K Soma, Julian K Christians
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174030 (2017)
Maternal overnutrition and obesity during pregnancy can have long-term effects on offspring physiology and behaviour. These developmental programming effects may be mediated by fetal exposure to glucocorticoids, which is regulated in part by placenta
Externí odkaz:
https://doaj.org/article/04df8c2463294d679ab2b9513d20584d
Autor:
Julian K Christians, Manjinder S Cheema, Ismael A Vergara, Cortney A Watt, Linda J Pinto, Nansheng Chen, Margo M Moore
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19325 (2011)
Infections caused by the fungus Aspergillus are a major cause of morbidity and mortality in immunocompromised populations. To identify genes required for virulence that could be used as targets for novel treatments, we mapped quantitative trait loci
Externí odkaz:
https://doaj.org/article/e183c379cd3649caa8c70b630e398ff9
Autor:
Fiona Oliver, Julian K Christians, Xiaojun Liu, Susan Rhind, Vinesh Verma, Claire Davison, Steve D M Brown, Paul Denny, Peter D Keightley
Publikováno v:
PLoS Biology, Vol 3, Iss 5, p e135 (2005)
The genetic basis of variation in complex traits remains poorly understood, and few genes underlying variation have been identified. Previous work identified a quantitative trait locus (QTL) responsible for much of the response to selection on growth
Externí odkaz:
https://doaj.org/article/b3955efa92b0418fa13e07986e0c8024
Autor:
Julian K. Christians
Publikováno v:
Reproductive Sciences. 29:1895-1907
Fetal sex affects the risk of pregnancy complications and the long-term effects of prenatal environment on health. Some have hypothesized that growth strategies differ between the sexes, whereby males prioritize growth whereas females are more respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de980988215e0c056b4010e485774571
https://doi.org/10.1007/s43032-021-00780-3
https://doi.org/10.1007/s43032-021-00780-3
Autor:
Julian K. Christians, Natalie A. Chow
Publikováno v:
Journal of developmental origins of health and disease. 13(6)
Males and females have been proposed to have different prenatal growth strategies, whereby males invest more in fetal growth and less in placental development, leaving them more susceptible to early-life adversity. We tested predictions of this hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cd8fbb7aec59bd6f5d73c883182156
https://pubmed.ncbi.nlm.nih.gov/35431021
https://pubmed.ncbi.nlm.nih.gov/35431021
Publikováno v:
Reproductive Biology and Endocrinology, Vol 17, Iss 1, Pp 1-12 (2019)
Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology : RB&E
Background Maternal nutrition during pregnancy has life-long consequences for offspring. However, the effects of maternal overnutrition and/ or obesity on fetal growth remain poorly understood, e.g., it is not clear why birthweight is increased in so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a548f43a6e58bdc66a6602ca1f68cd66
http://link.springer.com/article/10.1186/s12958-019-0482-y
http://link.springer.com/article/10.1186/s12958-019-0482-y
Autor:
David Grynspan, Julian K. Christians
Publikováno v:
Placenta. 76:1-5
Introduction Accelerated placental maturation is considered a sign of maternal vascular malperfusion, and is often interpreted as an adaptive, compensatory response by the placenta. We tested this interpretation by comparing outcomes in pregnancies w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0857a2d823c91b43dfa6c84cc11429bd
https://doi.org/10.1016/j.placenta.2019.01.012
https://doi.org/10.1016/j.placenta.2019.01.012