Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Julian J, Lum"'
Autor:
Marin Simunic, Jay T. Joshi, Helen Merkens, Nadine Colpo, Hsiou-Ting Kuo, Julian J. Lum, François Bénard
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-7 (2024)
Externí odkaz:
https://doaj.org/article/d7a3c8e0d16a4df99867cf7dee5f8f2d
Autor:
Nancy Guo, Aijun Yang, Fabiha Binte Farooq, Shreena Kalaria, Elena Moss, Lindsay DeVorkin, Mary Lesperance, François Bénard, Don Wilson, Anna V. Tinker, Farouk S. Nathoo, Phineas T. Hamilton, Julian J. Lum
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Unlike other histological types of epithelial ovarian carcinoma, clear cell ovarian carcinoma (CCOC) has poor response to therapy. In many other carcinomas, expression of the hypoxia-related enzyme Carbonic anhydrase IX (CAIX) by cancer cell
Externí odkaz:
https://doaj.org/article/95ede8de1ca14914bdce66a61cd611f5
Autor:
Alejandra M. Fuentes, Apurva Narayan, Kirsty Milligan, Julian J. Lum, Alex G. Brolo, Jeffrey L. Andrews, Andrew Jirasek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Tumour cells exhibit altered metabolic pathways that lead to radiation resistance and disease progression. Raman spectroscopy (RS) is a label-free optical modality that can monitor post-irradiation biomolecular signatures in tumour cells and
Externí odkaz:
https://doaj.org/article/735b32e284f743318c42f9cf976a8c6b
Autor:
Kirsty Milligan, Xinchen Deng, Ramie Ali-Adeeb, Phillip Shreeves, Samantha Punch, Nathalie Costie, Juanita M. Crook, Alexandre G. Brolo, Julian J. Lum, Jeffrey L. Andrews, Andrew Jirasek
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract This work combines Raman spectroscopy (RS) with supervised learning methods—group and basis restricted non-negative matrix factorisation (GBR-NMF) and linear discriminant analysis (LDA)—to aid in the prediction of clinical indicators of
Externí odkaz:
https://doaj.org/article/6d87c80d04c64553b8eedbe2b0aafe42
Publikováno v:
JMIR Human Factors, Vol 10, p e43551 (2023)
BackgroundPatients with head and neck cancer (HNC) carry a clinically significant symptom burden, have alterations in function (eg, impaired ability to chew, swallow, and talk), and decrease in quality of life. Furthermore, treatment impacts social a
Externí odkaz:
https://doaj.org/article/08ecd2961a164dc6a103fc326d9389c4
Autor:
Sarah MacPherson, Sarah Keyes, Marisa K. Kilgour, Julian Smazynski, Vanessa Chan, Jessica Sudderth, Tim Turcotte, Adria Devlieger, Jessie Yu, Kimberly S. Huggler, Jason R. Cantor, Ralph J. DeBerardinis, Christopher Siatskas, Julian J. Lum
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 380-393 (2022)
Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo. The comparison of five different culture media used for clinical T cell expansion revealed uni
Externí odkaz:
https://doaj.org/article/f33f2e28b0854ba7b43b89b360c06564
Autor:
Patrick B. Walter, Leah S. Hohman, Andrew Rokeby, Julian J. Lum, Robert Hagar, Lisa Lavrisha, Augusta Saulys, Frans A. Kuypers, Elliott Vichinsky, Claudia R. Morris
Publikováno v:
Complementary Therapies in Medicine, Vol 70, Iss , Pp 102856- (2022)
Objectives: L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit. Desig
Externí odkaz:
https://doaj.org/article/560b1ca54ac24f2ea448737dead2bb32
Autor:
Tian Zhao, Julian J. Lum
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The methionine cycle comprises a series of reactions that catabolizes and regenerates methionine. This process is crucial to many cellular functions, including polyamine synthesis, DNA synthesis, redox balance, and DNA and histone methylation. In res
Externí odkaz:
https://doaj.org/article/5375b0abb631417d97f9f087f52ae865
Autor:
Basile Tessier‐Cloutier, David DW Twa, Mahsa Marzban, Jennifer Kalina, Hye‐Jung E Chun, Nils Pavey, Zaidi Tanweer, Ruth L Katz, Julian J Lum, Davide Salina
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 4, Pp 385-396 (2021)
Abstract Tumour‐promoting inflammation is an emerging hallmark of cancer that is increasingly recognised as a therapeutic target. As a constituent measure of inflammation, tumour‐infiltrating neutrophils (TINs) have been associated with inferior
Externí odkaz:
https://doaj.org/article/9df4104f7a5d4c22932148e7d55d815a
Autor:
Kirsty Milligan, Xinchen Deng, Phillip Shreeves, Ramie Ali-Adeeb, Quinn Matthews, Alexandre Brolo, Julian J. Lum, Jeffrey L. Andrews, Andrew Jirasek
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract This work combines single cell Raman spectroscopy (RS) with group and basis restricted non-negative matrix factorisation (GBR-NMF) to identify individual biochemical changes associated with radiation exposure in three human cancer cell lines
Externí odkaz:
https://doaj.org/article/be7d93b845f34652a78ac742d2abbcae