Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Julian Heuberger"'
Autor:
Manqiang Lin, Kimberly Hartl, Julian Heuberger, Giulia Beccaceci, Hilmar Berger, Hao Li, Lichao Liu, Stefanie Müllerke, Thomas Conrad, Felix Heymann, Andrew Woehler, Frank Tacke, Nikolaus Rajewsky, Michael Sigal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The cellular organization of gastrointestinal crypts is orchestrated by different cells of the stromal niche but available in vitro models fail to fully recapitulate the interplay between epithelium and stroma. Here, we establish a colon ass
Externí odkaz:
https://doaj.org/article/0de83173096d4a10bb0d385aab0304aa
Autor:
Laura Kröhn, Aline Azabdaftari, Julian Heuberger, Christian Hudert, Matthias Zilbauer, Tilman Breiderhoff, Philip Bufler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Background and AimsIntestinal epithelial cells separate the luminal flora from lamina propria immune cells and regulate innate immune responses in the gut. An imbalance of the mucosal immune response and disrupted intestinal barrier integrity contrib
Externí odkaz:
https://doaj.org/article/f5c4bc7bb6d443d790a8cbb8b44f6419
Autor:
Marta Kapalczynska, Manqiang Lin, Jeroen Maertzdorf, Julian Heuberger, Stefanie Muellerke, Xiangsheng Zuo, Ramon Vidal, Imad Shureiqi, Anne-Sophie Fischer, Sascha Sauer, Hilmar Berger, Evelyn Kidess, Hans-Joachim Mollenkopf, Frank Tacke, Thomas F. Meyer, Michael Sigal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Helicobacter pylori causes gastric inflammation, gland hyperplasia and is linked to gastric cancer. Here the authors identify a BMP feedback loop between the stomach epithelium and surrounding stroma that controls gland homeostasis and demonstrate it
Externí odkaz:
https://doaj.org/article/d77fc1814d4b4a59a4f1c341261c1b01
Autor:
Anne-Sophie Fischer, Stefanie Müllerke, Alexander Arnold, Julian Heuberger, Hilmar Berger, Manqiang Lin, Hans-Joachim Mollenkopf, Jonas Wizenty, David Horst, Frank Tacke, Michael Sigal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
The stomach corpus epithelium is organized into anatomical units that consist of glands and pits. Mechanisms that control the cellular organization of corpus glands and enable their recovery upon injury are not well understood. R-spondin 3 (RSPO3) is
Externí odkaz:
https://doaj.org/article/53d37f46dde74c668522841da2d1352e
Autor:
Amina Iftekhar, Hilmar Berger, Nassim Bouznad, Julian Heuberger, Francesco Boccellato, Ulrich Dobrindt, Heiko Hermeking, Michael Sigal, Thomas F. Meyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Colibactin-producing pks+ Escherichia coli are frequent constituents of the human intestinal microbiota. Here, the authors show that short exposure of cells to pks+ E. coli induces chromosomal aberrations, genomic instability, and multiple features o
Externí odkaz:
https://doaj.org/article/6216b08bac074ebf879284a8ec39ba76
Autor:
Johanna Grinat, Julian Heuberger, Ramon Oliveira Vidal, Neha Goveas, Frauke Kosel, Antoni Berenguer-Llergo, Andrea Kranz, Annika Wulf-Goldenberg, Diana Behrens, Bálint Melcher, Sascha Sauer, Michael Vieth, Eduard Batlle, A. Francis Stewart, Walter Birchmeier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
Externí odkaz:
https://doaj.org/article/3b5f2ff3d1124d7c81f483c2f20a5a38
Autor:
Neha Goveas, Claudia Waskow, Kathrin Arndt, Julian Heuberger, Qinyu Zhang, Dimitra Alexopoulou, Andreas Dahl, Walter Birchmeier, Konstantinos Anastassiadis, A Francis Stewart, Andrea Kranz
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009250 (2021)
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells and adult homeostasis. Amongst many epigenetic marks, methylation of histone 3 lysine 4 (H3K4) i
Externí odkaz:
https://doaj.org/article/4875509f143d4a909776991e391ae158
Autor:
Julian Heuberger, Jakob Trimpert, Daria Vladimirova, Christian Goosmann, Manqiang Lin, Rosa Schmuck, Hans‐Joachim Mollenkopf, Volker Brinkmann, Frank Tacke, Nikolaus Osterrieder, Michael Sigal
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract SARS‐CoV‐2, the agent that causes COVID‐19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme‐2 (ACE2) as a receptor. Subsequent inflammation can promote r
Externí odkaz:
https://doaj.org/article/5396e49c30f44e5e8e0a119b1c47a08f
Autor:
Jane J. Thomas, Mona Abed, Julian Heuberger, Rostislav Novak, Yaniv Zohar, Angela P. Beltran Lopez, Julie S. Trausch-Azar, Ma. Xenia G. Ilagan, David Benhamou, Gunnar Dittmar, Raphael Kopan, Walter Birchmeier, Alan L. Schwartz, Amir Orian
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3388-3400 (2016)
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including
Externí odkaz:
https://doaj.org/article/d03b4a0af0244a48b43e395431f94d77
Autor:
Qionghua Zhu, Liang Fang, Julian Heuberger, Andrea Kranz, Jörg Schipper, Kathrin Scheckenbach, Ramon Oliveira Vidal, Daniele Yumi Sunaga-Franze, Marion Müller, Annika Wulf-Goldenberg, Sascha Sauer, Walter Birchmeier
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 415-428.e5 (2019)
Summary: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-function
Externí odkaz:
https://doaj.org/article/0bcc0bad88934e99882841e179172445