Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Julian Gutekunst"'
Autor:
Ihab Ansari, Llorenç Solé-Boldo, Meshi Ridnik, Julian Gutekunst, Oliver Gilliam, Maria Korshko, Timur Liwinski, Birgit Jickeli, Noa Weinberg-Corem, Michal Shoshkes-Carmel, Eli Pikarsky, Eran Elinav, Frank Lyko, Yehudit Bergman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract TET2/3 play a well-known role in epigenetic regulation and mouse development. However, their function in cellular differentiation and tissue homeostasis remains poorly understood. Here we show that ablation of TET2/3 in intestinal epithelial
Externí odkaz:
https://doaj.org/article/cbb5a9ce71a14585b4a2f3a138ff783a
Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses
Autor:
Llorenç Solé‐Boldo, Günter Raddatz, Julian Gutekunst, Oliver Gilliam, Felix Bormann, Michelle S Liberio, Daniel Hasche, Wiebke Antonopoulos, Jan‐Philipp Mallm, Anke S Lonsdorf, Manuel Rodríguez‐Paredes, Frank Lyko
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-22 (2022)
Abstract Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations, posing a significant medical and economic burden to health systems. KC originate in the epidermis and mainly comprise basal cell carcinoma (BCC) and
Externí odkaz:
https://doaj.org/article/f1877efb7d4b4f92a9c149e53c79c250
Autor:
Julian Gutekunst, Olena Maiakovska, Katharina Hanna, Panagiotis Provataris, Hannes Horn, Stephan Wolf, Christopher E. Skelton, Nathan J. Dorn, Frank Lyko
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Gutekunst et al. explore the phylogeographic origins of the marbled crayfish, Procambarus virginalis, a parthenogenetic freshwater species. Based on genomic data of the parent species, they demonstrate that both parental haplotypes of P. virginalis w
Externí odkaz:
https://doaj.org/article/0d97d83d138c43ac95d191f2838a94c0
Autor:
Olena Maiakovska, Ranja Andriantsoa, Sina Tönges, Carine Legrand, Julian Gutekunst, Katharina Hanna, Lucian Pârvulescu, Roman Novitsky, András Weiperth, Arnold Sciberras, Alan Deidun, Fabio Ercoli, Antonin Kouba, Frank Lyko
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Olena Maiakovska et al. provide whole-genome sequencing of the parthenogenetic and invasive marbled crayfish and develop a computational framework for data analysis of monoclonal genomes. These data and methodology allow the authors to demonstrate ge
Externí odkaz:
https://doaj.org/article/48668983ccee496d9fd4de038433bab9
Autor:
Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko, Manuel Rodríguez-Paredes
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals exp
Externí odkaz:
https://doaj.org/article/00088c8a4a8149b6ae3e7d7c5020a4fa
Autor:
Sina Tönges, Karthik Masagounder, Frank Lenich, Julian Gutekunst, Marvin Tönges, Jasmin Lohbeck, Aubry K. Miller, Florian Böhl, Frank Lyko
Publikováno v:
Frontiers in Ecology and Evolution, Vol 9 (2021)
The marbled crayfish (Procambarus virginalis) is a recently discovered freshwater crayfish species, which reproduces by apomictic parthenogenesis, resulting in a monoclonal, and all-female population. The animals were widely distributed through the a
Externí odkaz:
https://doaj.org/article/e906c84f198d43d28573a2a4715161a9
Autor:
Fanny Gatzmann, Cassandra Falckenhayn, Julian Gutekunst, Katharina Hanna, Günter Raddatz, Vitor Coutinho Carneiro, Frank Lyko
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background The parthenogenetic marbled crayfish (Procambarus virginalis) is a novel species that has rapidly invaded and colonized various different habitats. Adaptation to different environments appears to be independent of the selection of
Externí odkaz:
https://doaj.org/article/a62e5726087544848f37dd50f610528f
Autor:
Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Benedikt Brors, Esther Herpel, Ingo Nindl, Thomas G. Hofmann, Marc Winnefeld, Frank Lyko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from dis
Externí odkaz:
https://doaj.org/article/26b413b8fcbb4405904d85c489f5f2a2
Autor:
Laura Wiehle, Günter Raddatz, Stefan Pusch, Julian Gutekunst, Andreas von Deimling, Manuel Rodríguez-Paredes, Frank Lyko
Publikováno v:
Cell Stress, Vol 1, Iss 1, Pp 55-67 (2017)
Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced b
Externí odkaz:
https://doaj.org/article/6a4c908b649d42ec9d47b5fa4fa3fc7b
Autor:
Stefanie Geyh, Manuel Rodríguez-Paredes, Paul Jäger, Annemarie Koch, Felix Bormann, Julian Gutekunst, Christoph Zilkens, Ulrich Germing, Guido Kobbe, Frank Lyko, Rainer Haas, Thomas Schroeder
Publikováno v:
Haematologica, Vol 103, Iss 9 (2018)
Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood. To further characterize the pathological phenotype we performed RNA sequenc
Externí odkaz:
https://doaj.org/article/1eab8701a7414b56a75c1f95f656d1ea