Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Julian Grusovin"'
Autor:
Celine Deffrasnes, Glenn A Marsh, Chwan Hong Foo, Christina L Rootes, Cathryn M Gould, Julian Grusovin, Paul Monaghan, Michael K Lo, S Mark Tompkins, Timothy E Adams, John W Lowenthal, Kaylene J Simpson, Cameron R Stewart, Andrew G D Bean, Lin-Fa Wang
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005478 (2016)
Hendra and Nipah viruses (genus Henipavirus, family Paramyxoviridae) are highly pathogenic bat-borne viruses. The need for high biocontainment when studying henipaviruses has hindered the development of therapeutics and knowledge of the viral infecti
Externí odkaz:
https://doaj.org/article/990aacb096224e819841d625f05bf0c7
Hendra virus (HeV) is a zoonotic paramyxovirus belonging to the genus Henipavirus . HeV is highly pathogenic, and it can cause severe neurological and respiratory illnesses in both humans and animals, with an extremely high mortality rate of up to 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a386b4d7451ebe0ddb5e76eb53ab3538
https://europepmc.org/articles/PMC6002731/
https://europepmc.org/articles/PMC6002731/
Autor:
Lloyd D. Graham, Shane A. Seabrook, Bin Ren, Victor A. Streltsov, Louis Lu, Julian Grusovin, Thomas S. Peat, Matthew Pollard, Ronald J. Hill, Tram Phan, George O. Lovrecz, Pat Pilling, Ross Fernley
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:1954-1964
The heterodimeric ligand-binding region of theBovicola ovisecdysone receptor has been crystallized either in the presence of an ecdysteroid or a synthetic methylene lactam insecticide. Two X-ray crystallographic structures, determined at 2.7 Å resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021fef51a34facf1adc83e168428566e
https://doi.org/10.1107/s1399004714009626
https://doi.org/10.1107/s1399004714009626
Autor:
Matthew Pollard, Linda Howell, Brian J. O’Driscoll, George O. Lovrecz, Ross Fernley, Julian Grusovin, Peter J. James, Andris J. Liepa, Christa Leitner, Ronald J. Hill, Dionne A. Jones, Lloyd D. Graham, Wynona M. Johnson, Louis Lu, Kathleen A. Turner, Roland H. Nearn, Albert Hofmann, Woldeamanuel Birru, David A. Winkler, Karen E. Jarvis, Tram Phan
Publikováno v:
ResearcherID
Nuclear hormone receptors, such as the ecdysone receptor, often display a large amount of induced fit to ligands. The size and shape of the binding pocket in the EcR subunit changes markedly on ligand binding, making modelling methods such as docking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e24288e849385845e86742c0ba8a29
https://doi.org/10.1016/j.bmc.2010.06.020
https://doi.org/10.1016/j.bmc.2010.06.020
Autor:
K. H. Gough, Violet Stoichevska, Katrina Nunan, Colin W. Ward, Julian Grusovin, S. Lance Macaulay
Publikováno v:
Biochemical Journal. 350:741-746
munc18c is a critical protein involved in trafficking events associated with syntaxin 4 and which also mediates inhibitory effects on vesicle docking and/or fusion. To investigate the domains of munc18c responsible for its interaction with syntaxin 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d1f167861d215b4a51db78cfa51544
https://doi.org/10.1042/bj3500741
https://doi.org/10.1042/bj3500741
Autor:
Michael K. Lo, Julian Grusovin, Cameron R. Stewart, S. Mark Tompkins, Paul Monaghan, John W. Lowenthal, Christina L. Rootes, Glenn A. Marsh, Celine Deffrasnes, Cathryn M. Gould, Kaylene J. Simpson, Timothy E. Adams, Lin-Fa Wang, Chwan Hong Foo, Andrew G. D. Bean
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 3, p e1005478 (2016)
PLoS Pathogens, Vol 12, Iss 3, p e1005478 (2016)
Hendra and Nipah viruses (genus Henipavirus, family Paramyxoviridae) are highly pathogenic bat-borne viruses. The need for high biocontainment when studying henipaviruses has hindered the development of therapeutics and knowledge of the viral infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a5085f2c4a150cf01ce0b1ab14abc2
https://doi.org/10.1371/journal.ppat.1005478
https://doi.org/10.1371/journal.ppat.1005478
Autor:
I. Holmes, Melanie deSilva, Ian P. Street, M.C. Chung, David J. Curtis, Stupple Paul Anthony, Julian Grusovin, Danny Ganame, Richard C. Foitzik, Alison Thistlethwaite, Romina Lessene, Gill E. Lunniss, Stephen M. Jane, Brendon J. Monahan, Elizabeth Allan, Michelle Ang Camerino, Hong Yang, Ylva E. Bozikis, Karen L. White, Rachel Lagiakos, Alexandra E. Stupple, S.J. Hermans, Marica Nikac, Scott Raymond Walker, Wilhelmus J A Kersten, Thomas S. Peat, Ben Morrow, Emma Toulmin, Hendrik Falk, Stefan Eugen Sonderegger, Michael W. Parker, Susan A. Charman, Jo-Anne Pinson, Patricia A. Pilling
Publikováno v:
Cancer Research. 75:5371-5371
Increased expression or dysregulation of protein arginine methyltransferase 5 (PRMT5) activity is associated with poor prognosis in many cancers. Through increased methylation of epigenetic and non-epigenetic targets, the aberrant activity of PRMT5 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8c8cb45e89f0255f68906d2972ced15
https://doi.org/10.1158/1538-7445.am2015-5371
https://doi.org/10.1158/1538-7445.am2015-5371
Autor:
Violet Stoichevska, Colin W. Ward, Laura A. Castelli, Julian Grusovin, S. Lance Macaulay, Joanne M Ryan
Publikováno v:
FEBS letters. 528(1-3)
Munc18c has been shown to bind syntaxin 4 and to play a role in GLUT4 translocation and glucose transport, although this role is as yet poorly defined. In the present study, the effects of modulating the available level of munc18c on glucose transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1532901bd88d387125d47c32b9943655
https://pubmed.ncbi.nlm.nih.gov/12297296
https://pubmed.ncbi.nlm.nih.gov/12297296
Autor:
Michael W. Parker, Susan A. Charman, Stefan Eugen Sonderegger, Ian Holmes, Wilco Kersten, Hendrik Falk, Ian P. Street, Elizabeth Allan, Scott E. Walker, Richard C. Foitzik, Kurt Lackovic, Ylva Elisabet Bergman, Alison Gregg, Thomas S. Peat, Brendon J. Monahan, Yuen Tan, Julian Grusovin, Quan Zhao, M.C. Chung, Marcia Nikac, Michelle Ang Camerino, Kym N Lowes, Paul Stupple, Pat Pilling, David J. Curtis, Stephen M. Jane, Jo Alcindor
Publikováno v:
Blood. 120:2129-2129
Abstract 2129 The developmental switch in human β-like globin gene subtype from fetal (γ) to adult (β) that begins at birth foreshadows the onset of the hemoglobinopathies, β-thalassemia and sickle cell disease (SCD). In the clinical setting it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4ef873d521c038618c3e5f6bb8a4db9
https://doi.org/10.1182/blood.v120.21.2129.2129
https://doi.org/10.1182/blood.v120.21.2129.2129
Autor:
M. J. Frenkel, D. R. Hewish, C. S. Fernandez, Julian Grusovin, A. M. Alafaci, V. Stoichevska, Leah J. Cosgrove, Colin W. Ward, S. F. MacPherson, S L Macaulay, K. H. Gough, Mittur N. Jagadish, Amanda J. Verkuylen
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 104:153-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250e79fc08f48fd33edafba1aebe675d
https://doi.org/10.1055/s-0029-1211637
https://doi.org/10.1055/s-0029-1211637