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Akademický článek
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Publikováno v:
Biology Open, Vol 6, Iss 2, Pp 176-186 (2017)
The removal of mRNA transcript poly(A) tails by 3′→5′ exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiologica
Externí odkaz:
https://doaj.org/article/f09dfbf90f12490fad07452a766a2e56
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166553 (2016)
Phospholipase D-2 (PLD2) has a key role in breast cancer formation and metastasis formation with PLD small inhibitors reducing primary tumor growth. This study aimed to evaluate the importance of targeting PLD on the tumor microenvironment. We provid
Externí odkaz:
https://doaj.org/article/b8c4742784584fe48c8640ff35447bdd
Autor:
Julian Gomez-Cambronero
Publikováno v:
The Scientific World Journal, Vol 10, Pp 1356-1369 (2010)
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger phosphatidic acid (PA) and choline. PLD regulation in cells falls into two major signaling categories. One is via growth factors/mitogens, su
Externí odkaz:
https://doaj.org/article/431c57980dad4873bd990fe5928281db
Autor:
Poornima L N Kotha, Priyanka Sharma, Abimbola O Kolawole, Ran Yan, Mahmoud S Alghamri, Trisha L Brockman, Julian Gomez-Cambronero, Katherine J D A Excoffon
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004696 (2015)
Prevention of viral-induced respiratory disease begins with an understanding of the factors that increase or decrease susceptibility to viral infection. The primary receptor for most adenoviruses is the coxsackievirus and adenovirus receptor (CAR), a
Externí odkaz:
https://doaj.org/article/275f285828614c40bffe7475725a9901
Autor:
Julian Gomez-Cambronero, Sandra Muñoz-Galván, Marco Perez, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero
Publikováno v:
Oncogene. 38:1309-1323
Cancer cells are in continuous communication with the surrounding microenvironment and this communication can affect tumor evolution. In this work, we show that phospholipase D2 (PLD2) was overexpressed in colon tumors and is secreted by cancer cells
Autor:
Karen M. Henkels, Ramya Ganesan, Julian Gomez-Cambronero, Taylor E. Miller, Kristen Fite, Brandon A. Wilkins
Publikováno v:
Oncotarget
// Karen M. Henkels 2 , Taylor E. Miller 2 , Ramya Ganesan 2 , Brandon A. Wilkins 2 , Kristen Fite 2 and Julian Gomez-Cambronero 1,2 1 Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women Hospital and Harvard Medical School,
Autor:
Charles N. Serhan, Nagarjuna R. Cheemarla, Xavier de la Rosa, Julian Gomez-Cambronero, Ramya Ganesan, Krushangi N. Shah, Karen M. Henkels, Stephania Libreros
Publikováno v:
FASEB J
A successful acute inflammatory response results in the elimination of infectious agents by neutrophils and monocytes, followed by resolution and repair through tissue-resident and recruited macrophages. Resolvins (D-series and E-series) are pro-reso
Autor:
Julian Gomez-Cambronero
Publikováno v:
Cancer and Metastasis Reviews. 37:491-507
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is difficult to treat since cells lack the three receptors (ES, PR, or HER) that the most effective treatments target. We have used a well-established TNBC cell line
Autor:
Charles N. Serhan, Krushangi N. Shah, Ramya Ganesan, Karen M. Henkels, Julian Gomez-Cambronero, Nagarjuna R. Cheemarla, Xavier de la Rosa, Stephania Libreros
A successful acute inflammatory response results in the elimination of infectious agents by neutrophils and monocytes, followed by resolution and repair by tissue-resident and recruited macrophages. D-series resolvins are pro-resolving mediators invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec60b9976c1d429b85107c0715cff60