Zobrazeno 1 - 10
of 608
pro vyhledávání: '"Julian F R, Paton"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The dysfunction of ion channels is a causative factor in a variety of neurological diseases, thereby defining the implicated channels as key drug targets. The detection of functional changes in multiple specific ionic currents currently pres
Externí odkaz:
https://doaj.org/article/7871a1c2bf0943439c47481612d6acc0
Autor:
Ahmed El-Medany, Zoe H. Adams, Hazel C. Blythe, Katrina A. Hope, Adrian H. Kendrick, Ana Paula Abdala Sheikh, Julian F. R. Paton, Angus K. Nightingale, Emma C. Hart
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-10 (2024)
Abstract Background The symptoms of long COVID, which include fatigue, breathlessness, dysregulated breathing, and exercise intolerance, have unknown mechanisms. These symptoms are also observed in heart failure and are partially driven by increased
Externí odkaz:
https://doaj.org/article/236c1c97f455485b8a53adfd42f438cb
Publikováno v:
Experimental Physiology, Vol 108, Iss 5, Pp 661-671 (2023)
Abstract The maintenance of glucose homeostasis is obligatory for health and survival. It relies on peripheral glucose sensing and signalling between the brain and peripheral organs via hormonal and neural responses that restore euglycaemia. Failure
Externí odkaz:
https://doaj.org/article/509894924c1846baaa3d9750d0bbd56d
Autor:
Renata M. Lataro, Davi J. A. Moraes, Fabio N. Gava, Ana C. M. Omoto, Carlos A. A. Silva, Fernanda Brognara, Lais Alflen, Vânia Brazão, Rafaela Pravato Colato, José Clóvis do Prado, Anthony P. Ford, Helio C. Salgado, Julian F. R. Paton
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Despite medications, heart failure worsens with time with many patients dying within five years of diagnosis. Here the authors show that blocking purinergic receptors in the carotid body stops heart failure progression, improves its function, reduces
Externí odkaz:
https://doaj.org/article/e48a184e40354b858155e387d19d724e
Autor:
Katrina Hope, Ben Chant, Thomas Hinton, Adrian H. Kendrick, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background An elevated ventilatory efficiency slope during exercise (minute ventilation/volume of expired CO2; VE/VCO2 slope) is a strong prognostic indicator in heart failure. It is elevated in people with heart failure with preserved ejection, many
Externí odkaz:
https://doaj.org/article/085ed34a9b68452c889b245ba69f9dfb
Autor:
Olivia M. S. Gold, Emma N. Bardsley, Anna P. Ponnampalam, Audrys G. Pauza, Julian F. R. Paton
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The carotid body is the primary peripheral chemoreceptor in the body, and critical for respiration and cardiovascular adjustments during hypoxia. Yet considerable evidence now implicates the carotid body as a multimodal sensor, mediating the chemoref
Externí odkaz:
https://doaj.org/article/a35802775aa34334ab0e7038d68b2044
Autor:
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial
Externí odkaz:
https://doaj.org/article/460633936e6841f2ab72308399796298
Autor:
Yasumasa Okada, Julian F. R. Paton, José López-Barneo, Richard J. A. Wilson, Nephtali Marina, Mieczyslaw Pokorski
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/3a592b4107d948678258180c45b61263
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The central site(s) mediating the cardiovascular actions of the apelin-apelin receptor (APJ) system remains a major question. We hypothesized that the sensory circumventricular organs (CVOs), interfacing between the circulation and deeper brain struc
Externí odkaz:
https://doaj.org/article/9e504c6c9cbc4ca8bb157b594f8515e6
Autor:
Kamal Abu-Hassan, Joseph D. Taylor, Paul G. Morris, Elisa Donati, Zuner A. Bortolotto, Giacomo Indiveri, Julian F. R. Paton, Alain Nogaret
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Designing efficient and scalable specialized neuromorphic circuits to integrate raw nervous stimuli and respond identically to biological neurons remains a challenge. Here, the authors propose an analog programming strategy to emulate biological neur
Externí odkaz:
https://doaj.org/article/0fc628234003432d833b704e1339427d