Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Julian E Stelzer"'
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Enhanced cardiac contractile function with increased sarcomere length (SL) is, in part, mediated by a decrease in the radial distance between myosin heads and actin. The radial disposition of myosin heads relative to actin is modulated by cardiac myo
Externí odkaz:
https://doaj.org/article/7a4032650e36471caaf5b238943dae29
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Myosin binding protein C (MyBPC) is a multi-domain protein with each region having a distinct functional role in muscle contraction. The central domains of MyBPC have often been overlooked due to their unclear roles. However, recent research shows pr
Externí odkaz:
https://doaj.org/article/04f6505003ae4d2bb1986355e562c257
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 20 (2023)
Background Omecamtiv mecarbil (OM) and danicamtiv both increase myocardial force output by selectively activating myosin within the cardiac sarcomere. Enhanced force generation is presumably due to an increase in the total number of myosin heads boun
Externí odkaz:
https://doaj.org/article/5c2e1e8ef52541f6b9bf787ac3d6ed92
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
With the advent of next-generation whole genome sequencing, many variants of uncertain significance (VUS) have been identified in individuals suffering from inheritable hypertrophic cardiomyopathy (HCM). Unfortunately, this classification of a geneti
Externí odkaz:
https://doaj.org/article/c87043c9a16545e6aa5be99cbc31d3be
Autor:
Jiayang Li, Ranganath Mamidi, Chang Yoon Doh, Joshua B. Holmes, Nikhil Bharambe, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
Decreased cardiac myosin-binding protein C (cMyBPC) expression due to inheritable mutations is thought to contribute to the hypertrophic cardiomyopathy (HCM) phenotype, suggesting that increasing cMyBPC content is of therapeutic benefit. In vitro ass
Externí odkaz:
https://doaj.org/article/f8403e13b7034978baad7fc118ddceba
Autor:
Katherine L. Dominic, Joohee Choi, Joshua B. Holmes, Mandeep Singh, Michael J. Majcher, Julian E. Stelzer
Publikováno v:
Journal of General Physiology. 155
Cardiac myosin binding protein C (cMyBPC) is an 11-domain sarcomeric protein (C0–C10) integral to cardiac muscle regulation. In vitro studies have demonstrated potential functional roles for regions beyond the N-terminus. However, the in vivo contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde3eee01aec0655597c0faa0eaee5e7
https://doi.org/10.1085/jgp.202213318
https://doi.org/10.1085/jgp.202213318
Autor:
Chang Yoon Doh, Katherine L. Dominic, Caitlin E. Swanberg, Nikhil Bharambe, Belinda B. Willard, Ling Li, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
ACS Omega. 7:14189-14202
Cardiac myosin binding protein C (cMyBPC) is a critical multidomain protein that modulates myosin cross bridge behavior and cardiac contractility. cMyBPC is principally regulated by phosphorylation of the residues within the M-domain of its N-terminu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302b46446482d1c5cef854974eb36c10
https://doi.org/10.1021/acsomega.2c00799
https://doi.org/10.1021/acsomega.2c00799
Publikováno v:
Biophysical Journal. 122:170a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::355009a8c826681f0b4bf012331d5551
https://doi.org/10.1016/j.bpj.2022.11.1066
https://doi.org/10.1016/j.bpj.2022.11.1066
Autor:
Ming C. Gong, Douglas A. Andres, Mihir Shah, Nemat Ali, Brooke M. Ahern, Andrea Sebastian, Julian E. Stelzer, Jiayang Li, Jonathan Satin, Wen Su, Sudhakar Veeranki, Bryana M. Levitan
Publikováno v:
J Biol Chem
Existing therapies to improve heart function target β-adrenergic receptor (β-AR) signaling and Ca(2+) handling and often lead to adverse outcomes. This underscores an unmet need for positive inotropes that improve heart function without any adverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff2d87fa6796bab81be2b7418c39d22
https://doi.org/10.1074/jbc.ra119.008782
https://doi.org/10.1074/jbc.ra119.008782
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:661-677
Mutations in cardiac myosin binding protein C (cMyBPC) are a major cause of hypertrophic cardiomyopathy (HCM). In particular, a single amino acid substitution of tyrosine to serine at residue 237 in humans (residue 235 in mice) has been linked to HCM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cbaec1f9ee4d51a7bf3928dc11a7cc
https://doi.org/10.1016/j.bbadis.2019.01.007
https://doi.org/10.1016/j.bbadis.2019.01.007