Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Julian Dow"'
Publikováno v:
Physiology. 38
Introduction: Dent Disease type 1 (DD1) results from X-linked, mutations in CLC-5 (2Cl-/H+ exchanger) and results in progressive renal failure by 20-40. DD1 is characterized by kidney Ca2+ mishandling, and subsequent hypercalcuria, calcium oxalate (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10de94b432126617bd6c3c418709181
https://doi.org/10.1152/physiol.2023.38.s1.5735119
https://doi.org/10.1152/physiol.2023.38.s1.5735119
Autor:
Panayiotis Anastasiou, Christopher Moore, Sareena Rana, Mona Tomaschko, Claire E. Pillsbury, Andrea de Castro, Jesse Boumelha, Edurne Mugarza, Sophie de Carné Trécesson, Ania Mikolajczak, Cristina Blaj, Robert Goldstone, Jacqueline A. M. Smith, Elsa Quintana, Miriam Molina-Arcas, Julian Downward
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mutant selective drugs targeting the inactive, GDP-bound form of KRASG12C have been approved for use in lung cancer, but resistance develops rapidly. Here we use an inhibitor, (RMC-4998) that targets RASG12C in its active, GTP-bound form, to
Externí odkaz:
https://doaj.org/article/f04ce583c0fc4b438b6298469e1bd117
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b7ee38902c29f5d4af928bb59dfd19
https://doi.org/10.1096/fasebj.2022.36.s1.r5347
https://doi.org/10.1096/fasebj.2022.36.s1.r5347
Autor:
Mohamed Ismail, Gareth Davies, Graham Sproat, Tiziana Monteverde, Jonathan Tart, Marta Acebrón-García-de-Eulate, Andrea Gohlke, David Hancock, Santosh Adhikari, Sandra Stefanovic-Barrett, David M Smith, Vikki Flemington, Emma S. Gleave-Hanford, Geoffrey A. Holdgate, Jason G. Kettle, Julian Downward
Publikováno v:
SLAS Discovery, Vol 29, Iss 8, Pp 100197- (2024)
The NanoBiT Biochemical Assay (NBBA) was designed as a biochemical format of the NanoBiT cellular assay, aiming to screen weak protein-protein interactions (PPIs) in mammalian cell lysates. Here we present a High Throughput Screening (HTS) applicatio
Externí odkaz:
https://doaj.org/article/ce753bb5efca48b380631a1a108578b9
Publikováno v:
Nature Reviews Nephrology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77dab547e137a3b4ac00bc48cabf8af
Autor:
Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here
Externí odkaz:
https://doaj.org/article/a58c4b29e1d8491b8078212067633916
Autor:
Alastair Magness, Emma Colliver, Katey S. S. Enfield, Claudia Lee, Masako Shimato, Emer Daly, David A. Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T. Hiley, Philip S. Hobson, Febe van Maldegem, James L. Reading, Sergio A. Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-imcyto), automated cell-type ann
Externí odkaz:
https://doaj.org/article/f61b4b8bd2f54cbd9679706490019396
Autor:
Goran Tomić, Clare Sheridan, Alice Y. Refermat, Marc P. Baggelaar, James Sipthorp, Bhuvana Sudarshan, Cory A. Ocasio, Alejandro Suárez-Bonnet, Simon L. Priestnall, Eleanor Herbert, Edward W. Tate, Julian Downward
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114224- (2024)
Summary: Metastasis is one of the defining features of pancreatic ductal adenocarcinoma (PDAC) that contributes to poor prognosis. In this study, the palmitoyl transferase ZDHHC20 was identified in an in vivo short hairpin RNA (shRNA) screen as criti
Externí odkaz:
https://doaj.org/article/76f4fd25faf047aa857156b8f167bc94
Autor:
Zijian Xu, Elizabeth R. Davies, Liudi Yao, Yilu Zhou, Juanjuan Li, Aiman Alzetani, Ben G. Marshall, David Hancock, Tim Wallis, Julian Downward, Rob M. Ewing, Donna E. Davies, Mark G. Jones, Yihua Wang
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101065- (2024)
The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated epithelial–mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells aug
Externí odkaz:
https://doaj.org/article/5746b35799c5474dafc24942f4b6652d
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6