Výsledky vyhledávání - "Julian C. Desmond"

Randomized, Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Fibrin Sealant VH S/D 4 s-apr (Artiss) to Improve Tissue Adherence in Subjects Undergoing Rhytidectomy

Autor: James R. Shire, T. Roderick Hester, Jason Diamond, Steve Zvi Abrams, Davis B. Nguyen, Rod J. Rohrich, Zachary E. Gerut, Julian C. Desmond, Achih H. Chen, Laura Silvati-Fidell

Publikováno v: Aesthetic Surgery Journal. 33:487-496

Background: Suction drains are commonly placed after rhytidectomy to avoid seroma formation that may result from dead spaces between skin layers. Fibrin sealants promote tissue adherence by crosslinking with extracellular matrix proteins, which may r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537fc9c6284489a90b25c19cf0536224
https://doi.org/10.1177/1090820x13479969

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Exploratory, Randomized, Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Adjuvant Fibrin Sealant VH S/D 4 S-Apr (ARTISS) in Patients Undergoing Rhytidectomy

Autor: Laura Silvati-Fidell, James R. Shire, Zachary E. Gerut, Achih H. Chen, Davis B. Nguyen, T. Roderick Hester, Julian C. Desmond, Jason Diamond, Steve Zvi Abrams

Publikováno v: Aesthetic Surgery Journal. 33:323-333

Background: Suction drains are commonly placed after rhytidectomy surgery to avoid seroma formation that may result from dead spaces between skin layers. Fibrin sealants promote tissue adherence by cross-linking with extracellular matrix proteins, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2091c50e1898d89cf37e775dc009f742
https://doi.org/10.1177/1090820x13477860

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Epigenetic regulation and molecular characterization of C/EBPα in pancreatic cancer cells

Autor: Takashi Kumagai, Sigal Gery, H. Phillip Koeffler, Norihiko Kawamata, Julian C. Desmond, Yasufumi Imai, Jee Hoon Song, Dorina Gui, Tadayuki Akagi, Jonathan W. Said

Publikováno v: International Journal of Cancer. 124:827-833

Molecular-targeted therapy is a hopeful approach for pancreatic cancer. Silencing of tumor suppressor genes can occur by histone deacetylation and/or DNA methylation in the promoter. Here, we identified epigenetically silenced genes in pancreatic can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8c17d2bb72552c26a2229a010a633f
https://doi.org/10.1002/ijc.23994

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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor: Effects on Gene Expression and Growth of Glioma Cells In vitro and In vivo

Autor: Jinwei Hu, Bindu Konda, John M. Ong, Norihiko Kawamata, Dong Yin, Keith L. Black, H. Phillip Koeffler, Julian C. Desmond

Publikováno v: Clinical Cancer Research. 13:1045-1052

Purpose: Histone acetylation is one of the main mechanisms involved in regulation of gene expression. During carcinogenesis, tumor-suppressor genes can be silenced by aberrant histone deacetylation. This epigenetic modification has become an importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79376474312666c9b2e380d10fc592d
https://doi.org/10.1158/1078-0432.ccr-06-1261

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CYR61: A New Measure of Lung Cancer Outcome

Autor: Ronald Legaspi, Robert J. McKenna, Akio Mori, Naoki Komatsu, Alberto M. Marchevsky, Carl W. Miller, H. Phillip Koeffler, Julian C. Desmond, James O’Kelly

Publikováno v: Cancer Investigation. 25:738-741

Cysteine-rich protein 61 (Cyr61) is a member of a family of growth factor-inducible, immediate-early genes. In this report, the authors measured the expression of Cyr61 mRNA in 94 human lung tumors and their normal matched lung samples. The Cyr61 mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07241f298f84026381417f4811b6d5da
https://doi.org/10.1080/02770900701512597

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19-Nor-1,25(OH)2D2 (a Novel, Noncalcemic Vitamin D Analogue), Combined with Arsenic Trioxide, Has Potent Antitumor Activity against Myeloid Leukemia

Autor: Julian C. Desmond, Takashi Kumagai, H. Phillip Koeffler, Martin Hewison, James O'Kelly, Susan V. Hughes, Lee-Yung Shih

Publikováno v: Cancer Research. 65:2488-2497

Recently, we reported that a novel, noncalcemic vitamin D analogue (19-nor-1,25(OH)2D2; paricalcitol) had anticancer activity. In this study, we explored if paricalcitol enhanced anticancer effects of other clinically useful drugs in vitro against a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56069b5387025eddb57d15e293438057
https://doi.org/10.1158/0008-5472.can-04-2800

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Cyr61 Suppresses Growth of Human Endometrial Cancer Cells

Autor: Carl W. Miller, Jonathan Mordechai Frank, Wenwen Chien, Jonathan W. Said, H. Phillip Koeffler, Julian C. Desmond, Takashi Kumagai

Publikováno v: Journal of Biological Chemistry. 279:53087-53096

Cyr61 (CCN1) is a member of the CCN protein family; these secreted proteins are involved in diverse biological processes such as cell adhesion, angiogenesis, apoptosis, and either growth arrest or growth stimulation depending on the cellular context.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90267a1ba613caebf99c5650401a140
https://doi.org/10.1074/jbc.m410254200

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Crystal Structures of Prostaglandin D2 11-Ketoreductase (AKR1C3) in Complex with the Nonsteroidal Anti-Inflammatory Drugs Flufenamic Acid and Indomethacin

Autor: Andrew L. Lovering, Christopher M. Bunce, Stephen M. Cummings, Scott A. White, Jon P. Ride, Julian C. Desmond

Publikováno v: Cancer Research. 64:1802-1810

It is becoming increasingly well established that nonsteroidal anti-inflammatory drugs (NSAID) protect against tumors of the gastrointestinal tract and that they may also protect against a variety of other tumors. These activities have been widely at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d9c4e96202e77553e3b90a6aa106da
https://doi.org/10.1158/0008-5472.can-03-2847

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Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells

Autor: Noriyuki Takai, Jonathan W. Said, Isao Miyakawa, Julian C. Desmond, H. Phillip Koeffler, Sadie Whittaker, Takashi Kumagai, Dorina Gui

Publikováno v: Clinical Cancer Research. 10:1141-1149

Purpose: HDAC inhibitors (HDACIs) have been shown to inhibit cancer cell proliferation, stimulate apoptosis, and induce cell cycle arrest. Our purpose was to investigate the antiproliferative effects of the HDACIs [suberoyl anilide bishydroxamine, va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bf01942395bb155c0126d66ddad496
https://doi.org/10.1158/1078-0432.ccr-03-0100

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Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new disease

Autor: S. L. Fenton, Christopher M. Bunce, K J W Mustard, J Pound, John Gordon, Mark T. Drayson, A Sarafeim, Julian C. Desmond, Q T Luong

Publikováno v: Leukemia. 17:568-575

Current therapies for Burkitt's lymphoma (BL) utilise combined cytotoxic chemotherapy, but these treatments are not always available in areas where the disease is endemic and are also markedly less successful in AIDS-related BL. Therefore, additional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318a689cc374e8f2228bc5a03d31d7e3
https://doi.org/10.1038/sj.leu.2402843

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