Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Julian C. Braz"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H2782-H2790
In congestive heart failure (CHF), coronary vascular relaxation is associated with endothelial dysfunction and nitric oxide (NO) deficiency. This study explored the reversibility of this process in hearts recovering from CHF and its related mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db622a8ed5860bfccede75b24210ffc
https://doi.org/10.1152/ajpheart.00831.2006
https://doi.org/10.1152/ajpheart.00831.2006
Autor:
Weiqun Shen, Juan Wang, Jie Wang, Robert M. Gill, Julian C. Braz, George E. Sandusky, Angela K. Corbly, Bonita D. Jones
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H3154-H3158
Left ventricular (LV) diastolic dysfunction is a fundamental impairment in congestive heart failure (CHF). This study examined LV diastolic function in the canine model of CHF induced by chronic coronary embolization (CCE). Dogs were implanted with c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffc227194dd551dfc85e1f81b9ede55
https://doi.org/10.1152/ajpheart.00052.2006
https://doi.org/10.1152/ajpheart.00052.2006
Autor:
Bryan Mitton, Guoxiang Chu, Jeffery D. Molkentin, Faisal F. Syed, Stephen B. Liggett, Hong-Sheng Wang, Piero Pollesello, Anand Pathak, Arto Annila, Evangelia G. Kranias, Harvey S. Hahn, Jiang Qian, Gerald W. Dorn, Jo El J. Schultz, Qunying Yuan, Xiaoyin Sun, Jason R. Waggoner, Julian C. Braz, Yehia Marreez, Jay Jin, Wen Zhao
Publikováno v:
Circulation. 113:995-1004
Background— Phospholamban (PLN) is an inhibitor of the Ca 2+ affinity of sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA2). The amino acid sequence of PLN is highly conserved, and although all species contain asparagine (Asn), human PLN is unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2488ac4ec25bb79ac1911568f2d28454
https://doi.org/10.1161/circulationaha.105.583351
https://doi.org/10.1161/circulationaha.105.583351
Autor:
Wen Zhao, Arnold Schwartz, Stephen B. Liggett, Su Wang, Evangelia G. Kranias, John N. Lorenz, Anna A. DePaoli-Roach, Margaret V. Westfall, Julian C. Braz, Kimberly N. Gregory, Timothy E. Hewett, Edward G. Lakatta, Ilona Bodi, Thomas F. Kimball, Jeffrey Robbins, Angus C. Nairn, Bogachan Sahin, Anand Pathak, Raisa Klevitsky, James A. Bibb, Jeffery D. Molkentin
Publikováno v:
Nature Medicine. 10:248-254
The protein kinase C (PKC) family of serine/threonine kinases functions downstream of nearly all membrane-associated signal transduction pathways. Here we identify PKC-alpha as a fundamental regulator of cardiac contractility and Ca(2+) handling in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee4ab426a522724626abed7b269fed9
https://doi.org/10.1038/nm1000
https://doi.org/10.1038/nm1000
Autor:
Susan F. Steinberg, Jeffery D. Molkentin, Julian C. Braz, Abdelkarim Sabri, Vitalyi O. Rybin, Jacob Short
Publikováno v:
Journal of Biological Chemistry. 278:14555-14564
Recent studies identify conventional protein kinase C (PKC) isoform phosphorylations at conserved residues in the activation loop and C terminus as maturational events that influence enzyme activity and targeting but are not dynamically regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19a79f243fab234f977d5882707a09a
https://doi.org/10.1074/jbc.m212644200
https://doi.org/10.1074/jbc.m212644200
Autor:
Orlando F. Bueno, Betty J. Glascock, Jeffery D. Molkentin, Leon J. De Windt, Benjamin J. Wilkins, Julian C. Braz, Thomas F. Kimball
Publikováno v:
Molecular and Cellular Biology. 22:7603-7613
A calcineurin-nuclear factor of activated T cells (NFAT) regulatory pathway has been implicated in the control of cardiac hypertrophy, suggesting one mechanism whereby alterations in intracellular calcium handling are linked to the expression of hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd628740dad6492566273ff62bb2617a
https://doi.org/10.1128/mcb.22.21.7603-7613.2002
https://doi.org/10.1128/mcb.22.21.7603-7613.2002
Publikováno v:
The Journal of Cell Biology
Members of the protein kinase C (PKC) isozyme family are important signal transducers in virtually every mammalian cell type. Within the heart, PKC isozymes are thought to participate in a signaling network that programs developmental and pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63705306b3cb7952def2de7ae5348a8
http://europepmc.org/articles/PMC2173307
http://europepmc.org/articles/PMC2173307
Autor:
Betty J. Glascock, Hae W. Lim, Orlando F. Bueno, Thomas F. Kimball, Leon J. De Windt, Roger J. Hajjar, Federica del Monte, Ulrike Delling, Jeffery D. Molkentin, Julian C. Braz, Qiangrong Liang
Publikováno v:
Proceedings of the National Academy of Sciences. 98:3322-3327
The Ca 2+ -calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the hypertrophic response of the myocardium. Recently, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cc9a9081255ea46b1b66bf0e1d2f49
https://doi.org/10.1073/pnas.031371998
https://doi.org/10.1073/pnas.031371998
Autor:
Julian C. Braz, Robert M. Gill, Angela K. Corbly, Qingyu Wu, Najia Jin, Bonita D. Jones, Weiqun Shen, Chris J. Vlahos
Publikováno v:
European journal of heart failure. 11(8)
Aims Activation of phosphoinositide-3 kinase (PI3K) is essential for cell growth, relating to adaptive and maladaptive cardiac hypertrophy. This longitudinal canine study was designed to investigate the role of PI3Kα and PI3Kγ in cardiac remodellin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0b617c755766e9c5e86451198340d8
https://pubmed.ncbi.nlm.nih.gov/19633101
https://pubmed.ncbi.nlm.nih.gov/19633101
Publikováno v:
Journal of biomedical optics. 12(5)
Structural proteins such as elastin and collagen can be readily imaged by using two-photon excitation and second-harmonic generation microscopic techniques, respectively, without physical or biochemical processing of the tissues. This time- and effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0967784a82b73c2c9f5fc49ab07b5f
https://pubmed.ncbi.nlm.nih.gov/17994896
https://pubmed.ncbi.nlm.nih.gov/17994896