Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Julian Burks"'
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Gastrointestinal (GI) cancers represent a complex array of cancers that affect the digestive system. This includes liver, pancreatic, colon, rectal, anal, gastric, esophageal, intestinal and gallbladder cancer. Patients diagnosed with certain GI canc
Externí odkaz:
https://doaj.org/article/a83e8ee5bc5e4d7da25be75f73d5b7ad
Autor:
Julian Burks, Sandeep Nadella, Abdullah Mahmud, Charoen Mankongpaisarnrung, Juan Wang, Jong-In Hahm, Robin D. Tucker, Narayan Shivapurkar, Stephan T. Stern, Jill P. Smith
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 1, Pp 17-32 (2018)
Pancreatic ductal adenocarcinoma (PDAC) remains the most aggressive malignancy with the lowest 5-year survival rate of all cancers in part owing to the lack of tumor-specific therapy and the rapid metastatic nature of this cancer. The gastrointestina
Externí odkaz:
https://doaj.org/article/2b74bdbfe6f94384abdd7ecb6ed5e1b1
Autor:
Sandeep Nadella, Jill Smith, Julian Burks, Abdulhameed Al-Sabban, Juan Wang, Robin Tucker, Gloria Inyang
Publikováno v:
Journal of Clinical and Translational Science, Vol 1, Pp 60-61 (2017)
OBJECTIVES/SPECIFIC AIMS: Epidemiologic studies have found that the incidence of pancreatic cancer is greatest in countries that consume diets high in fat. The gastrointestinal peptide cholecystokinin (CCK) is released from the duodenum in response t
Externí odkaz:
https://doaj.org/article/3fd7b4300fa8404d90e672c35b1ea471
Publikováno v:
Cancer Immunol Immunother
Interferon-stimulated gene 15 (ISG15) is a 15 kDa protein induced by type I interferons (IFN-α and IFN-β) and is a member of the ubiquitin-like superfamily of proteins. The ISG15 pathway is highly expressed in various malignancies, including pancre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8c7da80e1c202b1d926f063775dccf
https://doi.org/10.1007/s00262-019-02422-9
https://doi.org/10.1007/s00262-019-02422-9
Autor:
Lynda Sutton, Julian Burks, Hong Cao, Nicholas Osborne, Jill P. Smith, Rebecca Sundseth, Alexander Kroemer, Xunxian Liu, Allen Cato
Publikováno v:
Cancer Immunol Immunother
Pancreatic cancer has been termed a 'recalcitrant cancer' due to its relative resistance to chemotherapy and immunotherapy. This resistance is thought to be due in part to the dense fibrotic tumor microenvironment and lack of tumor infiltrating CD8 +
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8183f7b6d4e2148b8d31fd2052e2d96a
https://doi.org/10.1007/s00262-019-02398-6
https://doi.org/10.1007/s00262-019-02398-6
Autor:
Ashley Jermusyck, Irene Collins, Juan Wang, Narayan Shivapurkar, Sandeep Nadella, Emanuel F. Petricoin, Matthew Huber, Simina M. Boca, Hong Cao, Eveline E. Vietsch, K. Alex Hodge, Jill P. Smith, Bhaskar Kallakury, Waxing Cui, Mariaelena Pierobon, Laufey T. Amundadottir, Robin D. Tucker, Julian Burks
Publikováno v:
Pancreas. 48:894-903
Objective The KRAS gene is the most frequently mutated gene in pancreatic cancer, and no successful anti-Ras therapy has been developed. Gastrin has been shown to stimulate pancreatic cancer in an autocrine fashion. We hypothesized that reactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb7dcf68c602d802790cad165d14396
https://doi.org/10.1097/mpa.0000000000001360
https://doi.org/10.1097/mpa.0000000000001360
Autor:
Robin D. Tucker, Sandeep Nadella, Stephan T. Stern, Jong-in Hahm, Julian Burks, Charoen Mankongpaisarnrung, Jill P. Smith, Juan Wang, Abdullah Mahmud, Narayan Shivapurkar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 1, Pp 17-32 (2018)
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) remains the most aggressive malignancy with the lowest 5-year survival rate of all cancers in part owing to the lack of tumor-specific therapy and the rapid metastatic nature of this cancer. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61522b2ac99ce2ed01e32ab414711f3
https://doi.org/10.1016/j.jcmgh.2018.02.013
https://doi.org/10.1016/j.jcmgh.2018.02.013
Autor:
Marie E. Zamanis, Juan Wang, Robin D. Tucker, William Bukowski, Julian Burks, Sandeep Nadella, Gloria Inyang, Abdulhameed Al-Sabban, Narayan Shivapurkar, Jill P. Smith
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 315(5)
The gastrointestinal peptide cholecystokinin (CCK) is released from the duodenum in response to dietary fat to aid in digestion, and plasma CCK levels are elevated with the consumption of high-fat diets. CCK is also a trophic peptide for the pancreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08532701fa128eb8ca9454c5bc2bdfa9
https://pubmed.ncbi.nlm.nih.gov/29927319
https://pubmed.ncbi.nlm.nih.gov/29927319
Publikováno v:
Oncotarget
Interferon-Stimulated Gene 15 (ISG15), an antagonist of the canonical ubiquitin pathway, is frequently overexpressed in various cancers. In cancer cells, ISG15 is detected as free (intracellular) and conjugated to cellular proteins (ISGylation). Free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6cc2684d6bac293a183cf985f829fd
https://doi.org/10.18632/oncotarget.3372
https://doi.org/10.18632/oncotarget.3372
Autor:
Jill P. Smith, Lynda Sutton, Xunxian H Liu, Nicholas Osborne, Julian Burks, Hong Cao, Alexander Kroemer, Rebecca Sundseth, Allen Cato
Publikováno v:
Journal of Clinical Oncology. 37:259-259
259 Background: Pancreatic cancer is poorly responsive to therapy due to fibrosis in the tumor microenvironment and nonspecificity of treatments. The peptide gastrin stimulates growth of pancreatic cancer in an autocrine fashion. Polyclonal Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b203d9b654e01fc1eb697a9649163f4
https://doi.org/10.1200/jco.2019.37.4_suppl.259
https://doi.org/10.1200/jco.2019.37.4_suppl.259