Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Julian Breidenbach"'
Autor:
Rabea Voget, Julian Breidenbach, Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach, Lan Phuong Vu, Renato H. Weiße, Ulrike Bartz, Norbert Sträter, Christa E. Müller, Michael Gütschow
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2349-2357 (2024)
A titrant for the SARS-CoV-2 main protease (Mpro) was developed that enables, for the first time, the exact determination of the concentration of the enzymatically active Mpro by active-site titration. The covalent binding mode of the tetrapeptidic t
Externí odkaz:
https://doaj.org/article/58da7d67bdec41a39ad53783d3a36b34
Autor:
Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa E. Müller, Jochen Bodem
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3972 (2023)
Recently, we have described novel pyridyl indole esters and peptidomimetics as potent inhibitors of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) main protease. Here, we analysed the impact of these compounds on viral replicat
Externí odkaz:
https://doaj.org/article/50b34bd95baa44908120300269e30a3a
Autor:
Nina Geiger, Dominik Thimm, Thanigaimalai Pillaiyar, Robin Gedschold, Laura Schäkel, Michael Gütschow, Christa E. Müller, Ghazl Al Hamwi, Maria Zyulina, Vittoria Lopez, Christin Vielmuth, Katharina Sylvester, Miriam Diett, Lan Phuong Vu, Vigneshwaran Namasivayam, Julian Breidenbach, Anke C. Schiedel, Jochen Bodem, Salahuddin Mirza, Carina Lemke
Publikováno v:
Angewandte Chemie. 133:10515-10521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff9821b9fd888dcc360c6ff44e464c3
https://doi.org/10.1002/ange.202016961
https://doi.org/10.1002/ange.202016961
Autor:
Salahuddin Mirza, Carina Lemke, Robin Gedschold, Dominik Thimm, Miriam Diett, Nina Geiger, Christa E. Müller, Julian Breidenbach, Michael Gütschow, Jochen Bodem, Christin Vielmuth, Anke C. Schiedel, Katharina Sylvester, Vittoria Lopez, Lan Phuong Vu, Vigneshwaran Namasivayam, Thanigaimalai Pillaiyar, Laura Schäkel, Ghazl Al Hamwi, Maria Zyulina
Publikováno v:
Angewandte Chemie (International Ed. in English)
The main protease of SARS‐CoV‐2 (Mpro), the causative agent of COVID‐19, constitutes a significant drug target. A new fluorogenic substrate was kinetically compared to an internally quenched fluorescent peptide and shown to be ideally suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad0987f44a1481deac8275f2d5abd33
http://europepmc.org/articles/PMC8014119
http://europepmc.org/articles/PMC8014119
Publikováno v:
Biochimica et Biophysica Acta. Proteins and Proteomics
Coumarins represent well-established structures to introduce fluorescence into tool compounds for biochemical investigations. They are valued for their small size, chemical stability and accessibility as well as their tunable photochemical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a492e4868d9d3d61cf157ef1f1f2e53d
https://pubmed.ncbi.nlm.nih.gov/32405284
https://pubmed.ncbi.nlm.nih.gov/32405284
Autor:
O'Boyle, Niamh M.1 (AUTHOR) nioboyle@tcd.ie, Helesbeux, Jean-Jacques2 (AUTHOR), Meegan, Mary J.1 (AUTHOR), Sasse, Astrid1 (AUTHOR), O'Shaughnessy, Elizabeth1 (AUTHOR), Qaisar, Alina1 (AUTHOR), Clancy, Aoife1 (AUTHOR), McCarthy, Florence3 (AUTHOR), Marchand, Pascal4 (AUTHOR)
Publikováno v:
Pharmaceuticals (14248247). Mar2023, Vol. 16 Issue 3, p432. 54p.
Autor:
Geiger, Nina1 (AUTHOR), Diesendorf, Viktoria1 (AUTHOR), Roll, Valeria1 (AUTHOR), König, Eva-Maria1 (AUTHOR), Obernolte, Helena2 (AUTHOR), Sewald, Katherina2 (AUTHOR), Breidenbach, Julian3 (AUTHOR), Pillaiyar, Thanigaimalai3 (AUTHOR), Gütschow, Michael3 (AUTHOR), Müller, Christa E.3 (AUTHOR), Bodem, Jochen1 (AUTHOR) Jochen.bodem@uni-wuerzburg.de
Publikováno v:
International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3972. 7p.
Autor:
Mohamed, Abdalla R., Mostafa, Ahmed, El Hassab, Mahmoud A., Hedeab, Gomaa M., Mahmoud, Sara H., George, Riham F., Georgey, Hanan H., Abdel Gawad, Nagwa M., El-Ashrey, Mohamed K.
Publikováno v:
RSC Medicinal Chemistry; May2023, Vol. 14 Issue 5, p899-920, 22p
Publikováno v:
NewsRx COVID-19 Weekly; 3/10/2023, p126-126, 1p
Autor:
Breidenbach, Julian, Lemke, Carina, Pillaiyar, Thanigaimalai, Schäkel, Laura, Al Hamwi, Ghazl, Diett, Miriam, Gedschold, Robin, Geiger, Nina, Lopez, Vittoria, Mirza, Salahuddin, Namasivayam, Vigneshwaran, Schiedel, Anke C., Sylvester, Katharina, Thimm, Dominik, Vielmuth, Christin, Phuong Vu, Lan, Zyulina, Maria, Bodem, Jochen, Gütschow, Michael, Müller, Christa E.
Publikováno v:
Angewandte Chemie International Edition; 4/26/2021, Vol. 60 Issue 18, p10423-10429, 7p