Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Julian Avila‐Pacheco"'
Autor:
Amrisha Bhosle, Sena Bae, Yancong Zhang, Eunyoung Chun, Julian Avila-Pacheco, Ludwig Geistlinger, Gleb Pishchany, Jonathan N Glickman, Monia Michaud, Levi Waldron, Clary B Clish, Ramnik J Xavier, Hera Vlamakis, Eric A Franzosa, Wendy S Garrett, Curtis Huttenhower
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 338-361 (2024)
Abstract Microbial biochemistry is central to the pathophysiology of inflammatory bowel diseases (IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is thus necessary for diagnosis and management. Here, we systematical
Externí odkaz:
https://doaj.org/article/9dc7c22482b749b1948ab95a7d3ce206
Autor:
Alexander Sturm, Penny Sun, Julian Avila-Pacheco, Anne E. Clatworthy, Zohar Bloom-Ackermann, Michael G. Wuo, James E. Gomez, Soomin Jin, Clary B. Clish, Laura L. Kiessling, Deborah T. Hung
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Mycobacterium tuberculosis (Mtb) can adopt a non-growing dormant state during infection that may be critical to both active and latent tuberculosis. During dormancy, Mtb is widely tolerant toward antibiotics, a significant obstacle in curren
Externí odkaz:
https://doaj.org/article/3478c905ccf4486081f42e2a0d6d8f81
Autor:
Edwin Ardiansyah, Julian Avila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh, Hoang Thanh Hai, Kevin Bullock, Bachti Alisjahbana, Mihai G Netea, Riwanti Estiasari, Trinh Thi Bich Tram, Joseph Donovan, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Duc Bang, Ahmad Rizal Ganiem, Rovina Ruslami, Valerie ACM Koeken, Raph L Hamers, Darma Imran, Kartika Maharani, Vinod Kumar, Clary B Clish, Reinout van Crevel, Guy Thwaites, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong
Publikováno v:
eLife, Vol 12 (2023)
Background: Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand the characteristic immunopathology of tuberculosis. We performed targeted metabolomic analyses in a large cohort
Externí odkaz:
https://doaj.org/article/2cf2690812f847abb9ee5aa2f2ed4a1d
Autor:
Francois Moreau, Bruna Brasil Brunao, Xiang-Yu Liu, Frederic Tremblay, Kevin Fitzgerald, Julian Avila-Pacheco, Clary Clish, Ronald C. Kahn, Samir Softic
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 2, Pp 100324- (2023)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with increased risk in patients with metabolic syndrome. There are no FDA-approved treatments, but FXR agonists have shown promising results in clinical studies for NAF
Externí odkaz:
https://doaj.org/article/4dbc06ae1d814495a0c3d6eaa9e7acf3
Autor:
Donghai Wen, Zihe Zheng, Aditya Surapaneni, Bing Yu, Linda Zhou, Wen Zhou, Dawei Xie, Haochang Shou, Julian Avila-Pacheco, Sahir Kalim, Jiang He, Chi-Yuan Hsu, Afshin Parsa, Panduranga Rao, James Sondheimer, Raymond Townsend, Sushrut S. Waikar, Casey M. Rebholz, Michelle R. Denburg, Paul L. Kimmel, Ramachandran S. Vasan, Clary B. Clish, Josef Coresh, Harold I. Feldman, Morgan E. Grams, Eugene P. Rhee, the CKD Biomarkers Consortium and CRIC Study Investigators
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
BACKGROUND Metabolomic profiling in individuals with chronic kidney disease (CKD) has the potential to identify novel biomarkers and provide insight into disease pathogenesis.METHODS We examined the association between blood metabolites and CKD progr
Externí odkaz:
https://doaj.org/article/0a978b3ac5694b419b959298ed540858
Autor:
Oana A. Zeleznik, Raji Balasubramanian, Yibai Zhao, Lisa Frueh, Sarah Jeanfavre, Julian Avila-Pacheco, Clary B. Clish, Shelley S. Tworoger, A. Heather Eliassen
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Known modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer amo
Externí odkaz:
https://doaj.org/article/364911554b85499280a193b48fdf7611
Autor:
Oana A. Zeleznik, Clemens Wittenbecher, Amy Deik, Sarah Jeanfavre, Julian Avila-Pacheco, Bernard Rosner, Kathryn M. Rexrode, Clary B. Clish, Frank B. Hu, A. Heather Eliassen
Publikováno v:
Metabolites, Vol 12, Iss 5, p 372 (2022)
In epidemiological studies, samples are often collected long before disease onset or outcome assessment. Understanding the long-term stability of biomarkers measured in these samples is crucial. We estimated within-person stability over 10 years of m
Externí odkaz:
https://doaj.org/article/962c960d4e8c47d09b3e9b186888260e
Autor:
Shiho Fujisaka, Julian Avila-Pacheco, Marion Soto, Aleksandar Kostic, Jonathan M. Dreyfuss, Hui Pan, Siegfried Ussar, Emrah Altindis, Ning Li, Lynn Bry, Clary B. Clish, C. Ronald Kahn
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 3072-3086 (2018)
Summary: Diet, genetics, and the gut microbiome are determinants of metabolic status, in part through production of metabolites by the gut microbiota. To understand the mechanisms linking these factors, we performed LC-MS-based metabolomic analysis o
Externí odkaz:
https://doaj.org/article/60ccf368e5734442a9a4679d88badbcc
Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements
Autor:
Leila Pirhaji, Pamela Milani, Simona Dalin, Brook T. Wassie, Denise E. Dunn, Robert J. Fenster, Julian Avila-Pacheco, Paul Greengard, Clary B. Clish, Myriam Heiman, Donald C. Lo, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulat
Externí odkaz:
https://doaj.org/article/ec0af8273fb342fcbf9ccadba0111a01
Autor:
Lina Yao, Gabriel D. D’Agostino, Jinseok Park, Saiyu Hang, Arijit A. Adhikari, Yancong Zhang, Wei Li, Julian Avila-Pacheco, Sena Bae, Clary B. Clish, Eric A. Franzosa, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin
Publikováno v:
Nature Microbiology. 7:1404-1418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5b0768390a14cd19d037b3ed172615
https://doi.org/10.1038/s41564-022-01176-y
https://doi.org/10.1038/s41564-022-01176-y