Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julian Aiken"'
Autor:
Emily G. Hoffman, Ninoschka C. D'Souza, Julian Aiken, Sara Atherley, Richard Liggins, Michael C. Riddell
Publikováno v:
Diabetes, Obesity and Metabolism. 25:1547-1556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd6f5c662081854f345dffaedfcdccc
https://doi.org/10.1111/dom.15002
https://doi.org/10.1111/dom.15002
Autor:
null Emily G. Hoffman, null Ninoschka C. D'Souza, null Julian Aiken, null Sara Atherley, null Richard Liggins, null Michael C. Riddell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7208554a9262f2a32181498d5004be28
https://doi.org/10.1111/dom.15002/v2/response1
https://doi.org/10.1111/dom.15002/v2/response1
Autor:
Rawad Farhat, Julian Aiken, Ninoschka C. D'Souza, Daniel Appadurai, Grayson Hull, Eric Simonson, Richard T. Liggins, Michael C. Riddell, Owen Chan
Publikováno v:
Diabetes, obesitymetabolismREFERENCES. 24(5)
To evaluate the pharmacokinetics and efficacy of a novel somatostatin receptor 2 antagonist, ZT-01, to stimulate glucagon release in rats with type 1 diabetes (T1D).The pharmacokinetics of ZT-01 and PRL-2903 were assessed following intraperitoneal or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22553c402eb17fd95d966fb64cf4990f
https://pubmed.ncbi.nlm.nih.gov/35060297
https://pubmed.ncbi.nlm.nih.gov/35060297
Autor:
Aoibhe M. Pasieka, Richard Liggins, Owen Chan, Mahsa Jahangiriesmaili, Erin R. Mandel, Julian Aiken, Caylee A. Greenberg, Michael C. Riddell, Emily G. Hoffman, Ninoschka C. D’Souza, Trevor Teich
Publikováno v:
Endocrinology
Recent antecedent hypoglycemia is a known source of defective glucose counter-regulation in diabetes; the mechanisms perpetuating the cycle of progressive α-cell failure and recurrent hypoglycemia remain unknown. Somatostatin has been shown to suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc5ac8cf735bbd9a572f9721d5f122d
https://doi.org/10.1210/endocr/bqab189
https://doi.org/10.1210/endocr/bqab189
Publikováno v:
Diabetes. 70
Background: SSTR2a rescues glucagon counterregulation in type 1 diabetic rats. Here, we investigated its potential for resisting hypoglycemic onset in insulin-treated rats with T2D. Methods: T2D was induced in 8-9-week-old, male, Sprague-Dawley rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439f8de79697be6b1182ae1fbeccc974
https://doi.org/10.2337/db21-133-or
https://doi.org/10.2337/db21-133-or
Autor:
Julian Aiken, Michael C. Riddell, Richard Liggins, Eric Simonson, Rawad Farhat, Owen Chan, Ninoschka C. D’Souza
Publikováno v:
Diabetes. 69
Iatrogenic hypoglycemia remains one of the most serious risks for people with type 1 diabetes (T1D) undergoing intensive insulin therapy. Development of counterregulatory failure, occurring in the early stages of diabetes, highlighted by loss of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4572e9e96aaba5f52a2080253ad38ae
https://doi.org/10.2337/db20-9-lb
https://doi.org/10.2337/db20-9-lb
Publikováno v:
Diabetes and Vascular Disease Research. 16:28-37
Type 1 diabetes can have deleterious effects on skeletal muscle and its microvasculature. Our laboratory has recently identified murine double minute-2 as a master regulator of muscle microvasculature by controlling expression levels of two key molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7086ffe1df1001a4d1694ded99cd01e0
https://doi.org/10.1177/1479164118805928
https://doi.org/10.1177/1479164118805928
Autor:
Julian Aiken, Michael C. Riddell, Mehran Nejad-Mansouri, Emily G. Hoffman, Richard Liggins, Ninoschka C. D’Souza, Parinaz Zaree Bavani
Publikováno v:
Diabetes. 68
Somatostatin Receptor 2 antagonists (SSTR2a) increase glucagon counter-regulation to hypoglycemia in various rodent models of type-1 diabetes mellitus. Here we investigated the efficacy of SSTR2a in improving glucagon counter-regulation in a rat mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a28c3e48c0d6ae626a3feac1970e6b
https://doi.org/10.2337/db19-14-lb
https://doi.org/10.2337/db19-14-lb
Autor:
Olivier Birot, Julian Aiken
Publikováno v:
Biochemical and Biophysical Research Communications. 478:1548-1554
Murine Double Minute-2 (Mdm2) has been identified as an essential regulator of skeletal muscle angiogenesis and the pro-angiogenic activity of endothelial cells. We have recently demonstrated that the pro-angiogenic Vascular Endothelial Growth Factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3107f6e89ada7c752624f94a7850b8
https://doi.org/10.1016/j.bbrc.2016.08.150
https://doi.org/10.1016/j.bbrc.2016.08.150
Autor:
Tara L. Haas, Olivier Birot, Joseph Ciccone, I. Mark Olfert, Thomas Gustafsson, Julian Aiken, Guillaume Grenier, Geneviève Drouin, Anna Strömberg, Jovana Vojnovic, Emilie Roudier
Publikováno v:
The FASEB Journal. 30:1120-1134
We demonstrated in a previous study that murine double minute (Mdm)-2 is essential for exercise-induced skeletal muscle angiogenesis. In the current study, we investigated the mechanisms that regulate Mdm2 activity in response to acute exercise and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41ca07cd8027545a4f18f5d2b76cf1b
https://doi.org/10.1096/fj.15-276964
https://doi.org/10.1096/fj.15-276964