Zobrazeno 1 - 10
of 387
pro vyhledávání: '"Julian A Simon"'
Autor:
Beti Thompson, Mary A O'Connell, Karen Peterson, Michele Shuster, Marilyn Drennan, Helena Loest, Sarah Holte, Julian A Simon, Graciela A Unguez
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225894 (2019)
The demographic profile of the biomedical workforce in the U.S. does not reflect the population at large, raising concerns that there will be insufficient trained researchers in the future, and the scope of research interests will not be sufficiently
Externí odkaz:
https://doaj.org/article/e1d88990507b4035a0e0ea12a49f78c8
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66283 (2013)
SIRT1 is a mammalian NAD(+)-dependent histone deacetylase implicated in metabolism, development, aging and tumorigenesis. Prior studies that examined the effect of enterocyte-specific overexpression and global deletion of SIRT1 on polyp formation in
Externí odkaz:
https://doaj.org/article/37fcffa7d7e24cd8a085572bc45276eb
Autor:
Kelly N Owens, Felipe Santos, Brock Roberts, Tor Linbo, Allison B Coffin, Anna J Knisely, Julian A Simon, Edwin W Rubel, David W Raible
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e1000020 (2008)
Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide. While normal aging is the single greatest contributor, exposure to environmental toxins an
Externí odkaz:
https://doaj.org/article/4e47d174a9de48dd980ebcc8c300aaa8
Autor:
Tonibelle Gatbonton, Maria Imbesi, Melisa Nelson, Joshua M Akey, Douglas M Ruderfer, Leonid Kruglyak, Julian A Simon, Antonio Bedalov
Publikováno v:
PLoS Genetics, Vol 2, Iss 6 (2006)
Externí odkaz:
https://doaj.org/article/7622da5970cd434ea7762ea96c94227a
Autor:
Tonibelle Gatbonton, Maria Imbesi, Melisa Nelson, Joshua M Akey, Douglas M Ruderfer, Leonid Kruglyak, Julian A Simon, Antonio Bedalov
Publikováno v:
PLoS Genetics, Vol 2, Iss 3, p e35 (2006)
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We found 72 genes that when deleted confer short telomeres, and 80 genes that confer long telomeres relat
Externí odkaz:
https://doaj.org/article/5914d44c888a4855b7d2a633b3f83404
Autor:
Joseph A. Bellairs, Van A. Redila, Patricia Wu, Ling Tong, Alyssa Webster, Julian A. Simon, Edwin W. Rubel, David W. Raible
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
There are no approved therapeutics for the prevention of hearing loss and vestibular dysfunction from drugs like aminoglycoside antibiotics. While the mechanisms underlying aminoglycoside ototoxicity remain unresolved, there is considerable evidence
Externí odkaz:
https://doaj.org/article/730d1673827d458f99d9ea120893dffb
Autor:
Peter S. Nelson, Antonio Bedalov, Julian A. Simon, Charles Craik, Eric L. Schneider, Christopher M. Brown, Ilsa Coleman, Nigel Clegg, Elahe Mostaghel, Bruce Montgomery, Eva Corey, Colm Morrissey, Lawrence D. True, Muzdah S. Malik, Susana A. Hernandez, Tom Kim, Cynthia Heinlein, Jared M. Lucas
Supplementary Methods from The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b70a0a478981e7923967dceccecd26
https://doi.org/10.1158/2159-8290.22530317
https://doi.org/10.1158/2159-8290.22530317
Autor:
Peter S. Nelson, Antonio Bedalov, Julian A. Simon, Charles Craik, Eric L. Schneider, Christopher M. Brown, Ilsa Coleman, Nigel Clegg, Elahe Mostaghel, Bruce Montgomery, Eva Corey, Colm Morrissey, Lawrence D. True, Muzdah S. Malik, Susana A. Hernandez, Tom Kim, Cynthia Heinlein, Jared M. Lucas
Supplementary Figure S1. TMPRSS2 expression is associated with androgen receptor (AR) levels and is regulated by androgens in vivo. Supplementary Figure S2. Characterization of the differentiation status, Tmprss2 and AR expression in Tmprss2+/+ TRAMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621c11b3df847db8312e6c8feb54f950
https://doi.org/10.1158/2159-8290.22530320
https://doi.org/10.1158/2159-8290.22530320
Supplementary Fig. S2 from Identification and characterization of small-molecule inhibitors of hepsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f828103debb1fc1782a3274999c3f95
https://doi.org/10.1158/1535-7163.22482570
https://doi.org/10.1158/1535-7163.22482570
Hepsin is a type II transmembrane serine protease overexpressed in the majority of human prostate cancers. We recently demonstrated that hepsin promotes prostate cancer progression and metastasis and thus represents a potential therapeutic target. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cff155bd24db730a426711861a88df
https://doi.org/10.1158/1535-7163.c.6530952.v1
https://doi.org/10.1158/1535-7163.c.6530952.v1