Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Julian D. Smith"'
Publikováno v:
Organic Process Research & Development. 17:193-201
Tertiary carbinamine 5 is an isolated intermediate in the synthesis of a novel, inhaled β-2 adrenoreceptor agonist PF-610355. Process development for the key amide-formation and Ritter reactions, together with reaction understanding studies are disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6ef98f8ca6e404d83b12bb608d3ee1
https://doi.org/10.1021/op300341n
https://doi.org/10.1021/op300341n
Autor:
Stéphane Content, Thomas Dupont, Nicolas M. Fédou, Radoslav Penchev, Julian D. Smith, Flavien Susanne, Christopher Stoneley, Steven J. R. Twiddle
Publikováno v:
Organic Process Research & Development. 17:202-212
PF-610355 is a novel inhaled β-2 adrenoreceptor agonist. Process development of the final intermediate and the API are discussed with emphasis on the control of physical properties and subsequent i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07da42fe99aa526dad4c9b561279821b
https://doi.org/10.1021/op300342y
https://doi.org/10.1021/op300342y
Publikováno v:
Tetrahedron. 51:9413-9436
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da4401b14267742a08bcf1036f277808
https://doi.org/10.1016/0040-4020(95)00547-l
https://doi.org/10.1016/0040-4020(95)00547-l
Autor:
Robert W. Carling, Ian M. Mawer, Mark Peter Ridgill, John A. Kemp, Graeme Irvine Stevenson, Raymond Baker, Alan C. Foster, Michael Rowley, Paul D. Leeson, Janusz Jozef Kulagowski, Ian Stansfield, Julian D. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:299-304
3-Substituted-2-quinoloners ( 6–8 ) have been identified as glycine-site N-methyl-D-aspartate receptor antagonists. It is proposed that the α-phenyl lactam unit in the potent 4-hydroxy-3-phenyl derivatives ( 7d and 8b , L-701,315) may act as a gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788478eff0033a4937efc5d60a871f1f
https://doi.org/10.1016/s0960-894x(01)80897-0
https://doi.org/10.1016/s0960-894x(01)80897-0
Autor:
A M Moseley, John A. Kemp, Paul D. Leeson, Mark D. Tricklebank, George R. Marshall, Sarah Grimwood, Robert W. Carling, K. L. Saywell, Alan C. Foster, Julian D. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:65-70
Anticonvulsant activity has been optimized in a series of glycine-site NMDA antagonists based on 2-carboxy tetrahydroquinoline, leading to the benzylamine 7 (L-690,590), its methyl ester prodrug 13 (L-691,470) and the phenylalanine 8 (L-696,833) whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a89e339452c78232fba8d73424c70a2a
https://doi.org/10.1016/s0960-894x(00)80093-1
https://doi.org/10.1016/s0960-894x(00)80093-1
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97b1df49addfa18d6f057e44c168ee7
https://doi.org/10.1002/chin.199145177
https://doi.org/10.1002/chin.199145177
Autor:
Louis Barash, M. H. Fisher, E E Harris, Jeannette E. Brown, Julian D. Smith, F. S. Waksmunski, John C. Chabala, L. H. Peterson, Thomas R. Beattie, Richard J. Bochis, M. Tischler, Donald W. Graham, Lawrence F. Colwell, Henry Joshua, M. J. Jun. Wyvratt
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f952a6ef6aeb63949c2a06a83a2aeec2
https://doi.org/10.1002/chin.199210170
https://doi.org/10.1002/chin.199210170
Autor:
Gregory L. Helms, D. L. Jun. Williams, Julian D. Smith, Siobhan Stevens-Miles, Otto D. Hensens, Nallin Mary, Yiu-Kuen T. Lam, Suzanne E. Gartner, L. Herranz Rodriguez
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc3ee42b75614d14a77b29dc75647e8
https://doi.org/10.1002/chin.199530272
https://doi.org/10.1002/chin.199530272
Autor:
Ian Paterson, Julian D. Smith
Publikováno v:
The Journal of Organic Chemistry. 57:3261-3264
The C 1 -C 15 segment (±)-8 of swinholide A/scytophycin C was prepared in eight steps from (E)-4-chlorobut-3-en-2-one (10) in 19% overall yield with 87% diastereoselectivity. The C 7 stereocenter was controlled by the novel, vinylogous Mukaiyama ald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1738b01737e43a3464bb95999d0bd2f5
https://doi.org/10.1021/jo00038a002
https://doi.org/10.1021/jo00038a002
Autor:
Paul D. Leeson, Robert W. Carling, Kevin W. Moore, Angela M. Moseley, Julian D. Smith, Graeme Stevenson, Tony Chan, Raymond Baker, Alan C. Foster, Sarah Grimwood, John A. Kemp, George R. Marshall, Karst Hoogsteen
Publikováno v:
Journal of Medicinal Chemistry. 35:1954-1968
trans-2-Carboxy-5,7-dichloro-4-amidotetrahydroquinolines, evolved from the lead 5,7-dichlorokynurenic acid, have been synthesized and tested for in vitro antagonist activity at the glycine site on the N-methyl-D-aspartate (NMDA) receptor. Optimizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6df5f675a1e1d5d9da6ba21d3bf8b
https://doi.org/10.1021/jm00089a004
https://doi.org/10.1021/jm00089a004