Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Autor: Herbert Waldmann, Nobumoto Watanabe, Yushi Futamura, Makoto Muroi, Tatsuro Kawamura, Erchang Shang, Julian Wilke, Petra Janning, Hiroyuki Osada, Yasumitsu Kondoh, Slava Ziegler, Shigeki Takeda, Masayoshi Ueno

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 84:2484-2490

Discovery of small-molecule inducers of unique phenotypic changes combined with subsequent target identification often provides new insights into cellular functions. Here, we applied integrated profiling based on cellular morphological and proteomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e41cad06f7f3bbe3a1ddc6ecab824bd5
https://doi.org/10.1080/09168451.2020.1812375

Synthesis of Indomorphan Pseudo‐Natural Product Inhibitors of Glucose Transporters GLUT‐1 and ‐3

Autor: Konstanze F. Winklhofer, Sonja Sievers, Claude Ostermann, Luca Laraia, Melanie Schwalfenberg, Kirsten Tschapalda, Axel Pahl, Malte Metz, George Karageorgis, Marjorie A. Carnero Corrales, Javier Ceballos, Petra Janning, Elena S. Reckzeh, Julian Wilke, Herbert Waldmann, Dominik A. Sehr, Jessica Nowacki, Silke Brand, Slava Ziegler, Magnus Sellstedt

Publikováno v: Angewandte Chemie (International Ed. in English)
Ceballos, J, Schwalfenberg, M, Karageorgis, G, Reckzeh, E S, Sievers, S, Ostermann, C, Pahl, A, Sellstedt, M, Nowacki, J, Carnero Corrales, M A, Wilke, J, Laraia, L, Tschapalda, K, Metz, M, Sehr, D A, Brand, S, Winklhofer, K, Janning, P, Ziegler, S & Waldmann, H 2019, ' Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and-3 ', Angewandte Chemie-International Edition, vol. 58, no. 47, pp. 17016-17025 . https://doi.org/10.1002/anie.201909518

Bioactive compound design based on natural product (NP) structure may be limited because of partial coverage of NP‐like chemical space and biological target space. These limitations can be overcome by combining NP‐centered strategies with fragmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305dd5f68fe246f829aea5d5c5cb80d4
https://doi.org/10.1002/anie.201909518

By-product formation in repetitive PCR amplification of DNA libraries during SELEX.

Autor: Fabian Tolle, Julian Wilke, Jesper Wengel, Günter Mayer

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114693 (2014)

The selection of nucleic acid aptamers is an increasingly important approach to generate specific ligands binding to virtually any molecule of choice. However, selection-inherent amplification procedures are prone to artificial by-product formation t

Externí odkaz: https://doaj.org/article/f56aeec21d5d487a802dc24ee679231b

Discovery of small-molecule modulator of heterotrimeric G

Autor: Tatsuro, Kawamura, Yushi, Futamura, Erchang, Shang, Makoto, Muroi, Petra, Janning, Masayoshi, Ueno, Julian, Wilke, Shigeki, Takeda, Yasumitsu, Kondoh, Slava, Ziegler, Nobumoto, Watanabe, Herbert, Waldmann, Hiroyuki, Osada

Publikováno v: Bioscience, biotechnology, and biochemistry. 84(12)

Discovery of small-molecule inducers of unique phenotypic changes combined with subsequent target identification often provides new insights into cellular functions. Here, we applied integrated profiling based on cellular morphological and proteomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::166a4bf38d0db9386806d18951adea46
https://pubmed.ncbi.nlm.nih.gov/32867616

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion

Autor: Julian Wilke, Herbert Waldmann, Tatsuro Kawamura, Slava Ziegler, Nobumoto Watanabe, Hiroyuki Osada

Publikováno v: Bioorganic & Medicinal Chemistry. 26:1453-1461

Reactive oxygen species (ROS) play an essential role in the survival and progression of cancer. Moderate oxidative stress drives proliferation, whereas high levels of ROS induce cytotoxicity. Compared to cancer cells, healthy cells often exhibit lowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd5ea95c8bb57f0440d5353eeb64f2d
https://doi.org/10.1016/j.bmc.2017.11.009