Zobrazeno 1 - 10
of 889
pro vyhledávání: '"Julian, Parkhill"'
Autor:
Rathanin Seng, Chalita Chomkatekaew, Sarunporn Tandhavanant, Natnaree Saiprom, Rungnapa Phunpang, Janjira Thaipadungpanit, Elizabeth M. Batty, Nicholas P. J. Day, Wasun Chantratita, T. Eoin West, Nicholas R. Thomson, Julian Parkhill, Claire Chewapreecha, Narisara Chantratita
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Melioidosis is an often-fatal neglected tropical disease caused by an environmental bacterium Burkholderia pseudomallei. However, our understanding of the disease-causing bacterial lineages, their dissemination, and adaptive mechanisms remai
Externí odkaz:
https://doaj.org/article/ccedeb625bba493394654a3541de83c6
Autor:
Tengfei Ma, Ning Xie, Yuan Gao, Jiani Fu, Chun E. Tan, Qiu E. Yang, Shaolin Wang, Zhangqi Shen, Quanjiang Ji, Julian Parkhill, Congming Wu, Yang Wang, Timothy R. Walsh, Jianzhong Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, bla NDM-5, are rapidly spreading globally in both humans and animals. Given that carbapenems are listed on the WHO AWaRe watch group and are prohibited for use in anim
Externí odkaz:
https://doaj.org/article/0c8fbbf9704240e494654433d6bec2e6
Autor:
Tamim Khawaja, Tommi Mäklin, Teemu Kallonen, Rebecca A. Gladstone, Anna K. Pöntinen, Sointu Mero, Harry A. Thorpe, Ørjan Samuelsen, Julian Parkhill, Mateen Izhar, M. Waheed Akhtar, Jukka Corander, Anu Kantele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Multi-drug resistant (MDR) E. coli constitute a major public health burden globally, reaching the highest prevalence in the global south yet frequently flowing with travellers to other regions. However, our comprehension of the entire geneti
Externí odkaz:
https://doaj.org/article/d635e9e4516f48f2a27f06a072b4c6c3
Autor:
Aidan J. Taylor, Koji Yahara, Ben Pascoe, Seungwon Ko, Leonardos Mageiros, Evangelos Mourkas, Jessica K. Calland, Santeri Puranen, Matthew D. Hitchings, Keith A. Jolley, Carolin M. Kobras, Sion Bayliss, Nicola J. Williams, Arnoud H. M. van Vliet, Julian Parkhill, Martin C. J. Maiden, Jukka Corander, Laurence D. Hurst, Daniel Falush, Paul Keim, Xavier Didelot, David J. Kelly, Samuel K. Sheppard
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core (a
Externí odkaz:
https://doaj.org/article/b01240a0b60f44418e276da053e1f0fe
Autor:
Christopher Ruis, Aaron Weimann, Gerry Tonkin-Hill, Arun Prasad Pandurangan, Marta Matuszewska, Gemma G. R. Murray, Roger C. Lévesque, Tom L. Blundell, R. Andres Floto, Julian Parkhill
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract As observed in cancers, individual mutagens and defects in DNA repair create distinctive mutational signatures that combine to form context-specific spectra within cells. We reasoned that similar processes must occur in bacterial lineages, p
Externí odkaz:
https://doaj.org/article/cc2a1f59c84346ceb130c517a1c473fa
Autor:
Juan M. Belardinelli, Divya Arora, Charlotte Avanzi, William H. Wheat, Josephine M. Bryant, John S. Spencer, Tom L. Blundell, Julian Parkhill, R. Andres Floto, Mary Jackson
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Functional genomics analysis of Mycobacterium abscessus clinical isolates from chronically infected patients to identify genes under strong evolutionary pressure during lung adaptation identified phoR as one of the most frequently mutated. p
Externí odkaz:
https://doaj.org/article/2bf422acc9ed4da6817771c9620be1e0
Autor:
Salwaluk Panapipat, Naomi Waithira, Nicholas R. Thomson, Parinya Chamnan, Nicholas P.J. Day, Direk Limmathurotsakul, Julian Parkhill, Phumrapee Boonklang, Kesorn Angchagun, Sukritpong Pakdeerat, Chalita Chomkatekaew, Thatsanun Ngernseng, Gumphol Wongsuwan, Anoree Surawong, Vanaporn Wuthiekanun, Steve Walton, Jukka Corander, Narisara Chantratita, Julian Knight, Suwatthiya Siriboon, Emma E. Davenport, Susie Dunachie, Claire Chewapreecha, Sharon J. Peacock, Premjit Amornchai
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background Melioidosis is a frequently fatal disease caused by an environmental bacterium Burkholderia pseudomallei. The disease is prevalent in northeast Thailand, particularly among rice field farmers who are at risk of bacterial exposure through c
Externí odkaz:
https://doaj.org/article/00fbd24e444046d3a1cdd261beb976b9
Autor:
Jody Phelan, Paula Josefina Gomez-Gonzalez, Nuria Andreu, Yosuke Omae, Licht Toyo-Oka, Hideki Yanai, Reiko Miyahara, Supalert Nedsuwan, Paola Florez de Sessions, Susana Campino, Neneh Sallah, Julian Parkhill, Nat Smittipat, Prasit Palittapongarnpim, Taisei Mushiroda, Michiaki Kubo, Katsushi Tokunaga, Surakameth Mahasirimongkol, Martin L. Hibberd, Taane G. Clark
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Few genetic loci have been associated with tuberculosis infection, possibly because of the influence of genetic variation in the pathogen. Here, the authors integrate human and Mycobacterium tuberculosis genetics to find genome-genome interactions as
Externí odkaz:
https://doaj.org/article/2b522c62dfb541f2b481485cd6e24b3a
Autor:
Kelly L. Wyres, Andries van Tonder, Lotte M. Lambertsen, Regine Hakenbeck, Julian Parkhill, Stephen D. Bentley, Angela B. Brueggemann
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/43ee615a26324fc7b14072dcf882a197
Autor:
Yingbo Shen, Rong Zhang, Dongyan Shao, Lu Yang, Jiayue Lu, Congcong Liu, Xueyang Wang, Junyao Jiang, Boxuan Wang, Congming Wu, Julian Parkhill, Yang Wang, Timothy R. Walsh, George F. Gao, Zhangqi Shen
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 6, Pp 1168-1179 (2022)
Emergence of the colistin resistance gene, mcr-1, has attracted worldwide attention. Despite the prevalence of mcr-1-positive Escherichia coli (MCRPEC) strains in human carriage showing a significant decrease between 2016 and 2019, genetic difference
Externí odkaz:
https://doaj.org/article/077857d4ac6d4763a757bd3ccd382499