Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Julian, Grünewald"'
Autor:
Alessia Cavazza, Ayal Hendel, Rasmus O. Bak, Paula Rio, Marc Güell, Duško Lainšček, Virginia Arechavala-Gomeza, Ling Peng, Fatma Zehra Hapil, Joshua Harvey, Francisco G. Ortega, Coral Gonzalez-Martinez, Carsten W. Lederer, Kasper Mikkelsen, Giedrius Gasiunas, Nechama Kalter, Manuel A.F.V. Gonçalves, Julie Petersen, Alejandro Garanto, Lluis Montoliu, Marcello Maresca, Stefan E. Seemann, Jan Gorodkin, Loubna Mazini, Rosario Sanchez, Juan R. Rodriguez-Madoz, Noelia Maldonado-Pérez, Torella Laura, Michael Schmueck-Henneresse, Cristina Maccalli, Julian Grünewald, Gloria Carmona, Neli Kachamakova-Trojanowska, Annarita Miccio, Francisco Martin, Giandomenico Turchiano, Toni Cathomen, Yonglun Luo, Shengdar Q. Tsai, Karim Benabdellah
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102066- (2023)
The European Cooperation in Science and Technology (COST) is an intergovernmental organization dedicated to funding and coordinating scientific and technological research in Europe, fostering collaboration among researchers and institutions across co
Externí odkaz:
https://doaj.org/article/dff3b1dde38845db9319c7538193d46c
Autor:
Jonathan Y. Hsu, Julian Grünewald, Regan Szalay, Justine Shih, Andrew V. Anzalone, Kin Chung Lam, Max W. Shen, Karl Petri, David R. Liu, J. Keith Joung, Luca Pinello
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Prime editing guide RNA design is more complex than for standard CRISPR-based nucleases or base editors. Here the authors present PrimeDesign and PrimeVar for the rapid and simplified design of pegRNA and ngRNA combinations.
Externí odkaz:
https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
Autor:
Julian Grünewald, Bret R. Miller, Regan N. Szalay, Peter K. Cabeceiras, Christopher J. Woodilla, Eliza Jane B. Holtz, Karl Petri, J. Keith Joung
Publikováno v:
Nature Biotechnology. 41:337-343
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fbe46e882add82bb41098d55a07286
https://doi.org/10.1038/s41587-022-01473-1
https://doi.org/10.1038/s41587-022-01473-1
Autor:
Julian Grünewald, Andrea Schmidts
Publikováno v:
Nature Biomedical Engineering. 7:607-608
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c642fe9fab2b68c3891f3a4a9008f376
https://doi.org/10.1038/s41551-023-01042-0
https://doi.org/10.1038/s41551-023-01042-0
Autor:
Luca Pinello, Max W. Shen, Regan Szalay, Julian Grünewald, Jonathan Y. Hsu, J. Keith Joung, Andrew V. Anzalone, Justine Shih, David R. Liu, Kin Chung Lam, Karl Petri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Nature Communications
Nature Communications
Prime editing (PE) is a versatile genome editing technology, but design of the required guide RNAs is more complex than for standard CRISPR-based nucleases or base editors. Here we describe PrimeDesign, a user-friendly, end-to-end web application and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef65e9d4e85e74b4a85709efb6e1dc2
https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
https://doaj.org/article/641f29fd5ac64f28bbea06a81c5212bd
Autor:
J. Keith Joung, Ronghao Zhou, Sowmya Iyer, Bret R. Miller, Lukas M. Langner, Ibrahim C. Kurt, Julian Grünewald, Sara P. Garcia
Publikováno v:
Nature biotechnology
CRISPR-guided DNA cytosine and adenine base editors (CBEs and ABEs) are widely used for many applications1–4 but primarily create DNA base transitions (i.e., pyrimidine-to-pyrimidine, or purine-to-purine). Here we describe the engineering of two ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55363855f17e643e094eef4db9a52e3
https://doi.org/10.1038/s41587-020-0609-x
https://doi.org/10.1038/s41587-020-0609-x
Autor:
Jonathan Y. Hsu, Martin J. Aryee, Ronghao Zhou, J. Keith Joung, Lukas M. Langner, Sara P. Garcia, Bret R. Miller, Julian Grünewald, Sowmya Iyer, Caleb A. Lareau
Publikováno v:
Nature biotechnology
Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR-Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4372198978a9c533af57b06ded868f53
https://doi.org/10.1038/s41587-020-0535-y
https://doi.org/10.1038/s41587-020-0535-y
Autor:
Julian, Grünewald, Bret R, Miller, Regan N, Szalay, Peter K, Cabeceiras, Christopher J, Woodilla, Eliza Jane B, Holtz, Karl, Petri, J Keith, Joung
Publikováno v:
Nature biotechnology.
The CRISPR prime editor PE2 consists of a Streptococcus pyogenes Cas9 nickase (nSpCas9) fused at its C-terminus to a Moloney murine leukemia virus reverse transcriptase (MMLV-RT). Here we show that separated nSpCas9 and MMLV-RT proteins function as e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ef1528a626858568d2d968d958e16fc
https://pubmed.ncbi.nlm.nih.gov/36163548
https://pubmed.ncbi.nlm.nih.gov/36163548
Autor:
Sara P. Garcia, Martin J. Aryee, Sowmya Iyer, Caleb A. Lareau, J. Keith Joung, Julian Grünewald, Ronghao Zhou
Publikováno v:
Nature biotechnology
Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations1-4. However, we recently demonstrated that they can also induce transcriptome-wide guide-RNA-independent editing of RNA bases5, and created select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3273752aa9b6db770249c3a31816065
https://doi.org/10.1038/s41587-019-0236-6
https://doi.org/10.1038/s41587-019-0236-6
Autor:
Andrew V. Anzalone, Luca Pinello, J. Keith Joung, Jonathan Y. Hsu, Kin Chung Lam, Julian Grünewald, Max W. Shen, David R. Liu
Prime editing (PE) is a versatile genome editing technology, but design of the required guide RNAs is more complex than for standard CRISPR-based nucleases or base editors. Here we describe PrimeDesign, a user-friendly, end-to-end web application and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3dee4ac0b6ffab68fc5a6695f992bed
https://doi.org/10.1101/2020.05.04.077750
https://doi.org/10.1101/2020.05.04.077750
