Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Julia Wegner"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
TBK1 and IKKϵ are related, crucial kinases in antiviral immune signaling pathways downstream of cytosolic nucleic acid receptors such as cGAS and RIG-I-like receptors. Upon activation, they phosphorylate the transcription factors IRF3 and IRF7 and t
Externí odkaz:
https://doaj.org/article/605f63208adc4c4abaebae2e181d59cf
Autor:
Adham Abuelola Mohamed, Sofía Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G. Brooks, Martin Schlee
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12220 (2023)
Immune surveillance by natural killer (NK) cells and their recruitment to sites of inflammation renders them susceptible to viral infection, potentially modulating their effector function. Here, we analyzed innate RNA receptor signaling in NK cells d
Externí odkaz:
https://doaj.org/article/c42af2fea2934a43a0ee01234fb10506
Autor:
Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F. Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A. Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K. Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D’Rozario, Emily S. Thomas, Henry Li, Clemens A. Schmitt, Julie George, Roman K. Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T. Ullrich, Jens T. Siveke, Kadoaki Ohashi, Martin Schlee, Martin L. Sos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer
Externí odkaz:
https://doaj.org/article/9def69d01bbd4809814653393e15ac1f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Antigen-presenting myeloid cells like monocytes detect invading pathogens via pattern recognition receptors (PRRs) and initiate adaptive and innate immune responses. As analysis of PRR signaling in primary human monocytes is hampered by thei
Externí odkaz:
https://doaj.org/article/df695d989e5e473a8e61a590da09f681
Autor:
Bojana Lucic, Heng-Chang Chen, Maja Kuzman, Eduard Zorita, Julia Wegner, Vera Minneker, Wei Wang, Raffaele Fronza, Stefanie Laufs, Manfred Schmidt, Ralph Stadhouders, Vassilis Roukos, Kristian Vlahovicek, Guillaume J. Filion, Marina Lusic
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
HIV-1 usually targets active genes and integrates near the nuclear pore compartment. Here the authors show that recurrently targeted genes are proximal to super-enhancer genomic elements, which cluster in specific spatial compartments of the T cell n
Externí odkaz:
https://doaj.org/article/ba25bfe3536b45a1a6e80271dcdd382b
Autor:
Bojana Lucic, Heng-Chang Chen, Maja Kuzman, Eduard Zorita, Julia Wegner, Vera Minneker, Wei Wang, Raffaele Fronza, Stefanie Laufs, Manfred Schmidt, Ralph Stadhouders, Vassilis Roukos, Kristian Vlahovicek, Guillaume J. Filion, Marina Lusic
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/3d1d5e7230404516a394b38fd0e6f8d0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/ef00e324b8454a2ab1fc870d8beed79f
Autor:
Claudia Günther, Eva Bartok, Gunther Hartmann, Katrin Paeschke, Stefan Beissert, Alexander Rapp, Stephan Drukewitz, Peter Mirtschink, Ulrike Reuner, Daniel Hilbig, Martin Schlee, Julia Wegner, Nadia Eberl, Franziska Schmidt, Susann Meisterfeld, Fabian Ullrich, Sarah Rösing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb7d50d501093e2533a92eb1721d022
https://doi.org/10.26226/m.641999d4b9b42e0013e5917e
https://doi.org/10.26226/m.641999d4b9b42e0013e5917e
Autor:
Claudia Günther, Sarah Rösing, Fabian Ullrich, Susann Meisterfeld, Franziska Schmidt, Nadia Eberl, Julia Wegner, Martin Schlee, Anja Wieland, Daniel Hilbig, Ulrike Reuner, Peter Mirtschink, Stephan Drukewitz, Alexander Rapp, Thomas Zillinger, Stefan Beissert, Katrin Paeschke, Gunther Hartmann, Eva Bartok
Nucleic acid accumulation in repeat expansion disease poses multiple challenges to cellular integrity. Myotonic dystrophy type 2 (DM2) results from large CCTG repeats in the CNBP gene leading to myopathy and an increased prevalence of autoimmunity. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73fe764ca0d476cb3aaf19c774da75aa
https://doi.org/10.21203/rs.3.rs-1784722/v1
https://doi.org/10.21203/rs.3.rs-1784722/v1
Publikováno v:
Immunity. 54:1363-1365
CARD8 senses pathogen-associated protease activity and assembles a pyroptosis-inducing inflammasome, but detailed regulatory mechanisms have remained elusive. In this issue of Immunity, Sharif et al. use cryo-EM and biochemical assays to unveil how D