Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Julia W Grimstead"'
Autor:
Laureline Roger, Kelly L. Miners, Louise Leonard, Julia W. Grimstead, David A. Price, Duncan M. Baird, Kristin Ladell
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The fundamental basis of T cell memory remains elusive. It is established that antigen stimulation drives clonal proliferation and differentiation, but the relationship between cellular phenotype, replicative history, and longevity, which is likely e
Externí odkaz:
https://doaj.org/article/9fd079d5624c4d788d97c445966b751e
Autor:
Helene E B Geiller, Adam Harvey, Rhiannon E Jones, Julia W Grimstead, Kez Cleal, Eric A Hendrickson, Duncan M Baird
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010485 (2022)
Telomerase activity is the principal telomere maintenance mechanism in human cancers, however 15% of cancers utilise a recombination-based mechanism referred to as alternative lengthening of telomeres (ALT) that leads to long and heterogenous telomer
Externí odkaz:
https://doaj.org/article/c81ea65d1fdd4e569bfe1d5f11bd2374
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a
Externí odkaz:
https://doaj.org/article/cfce330374694ea4bad27a13a3243c22
Autor:
Boitelo T Letsolo, Rhiannon E Jones, Jan Rowson, Julia W Grimstead, W Nicol Keith, Gareth J S Jenkins, Duncan M Baird
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174833 (2017)
Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essenti
Externí odkaz:
https://doaj.org/article/d8f9b80fd6ea4b6196df8cda58935a64
Autor:
Rhiannon E. Jones, Sehyun Oh, Julia W. Grimstead, Jacob Zimbric, Laureline Roger, Nicole H. Heppel, Kevin E. Ashelford, Kate Liddiard, Eric A. Hendrickson, Duncan M. Baird
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1063-1076 (2014)
Short dysfunctional telomeres are capable of fusion, generating dicentric chromosomes and initiating breakage-fusion-bridge cycles. Cells that escape the ensuing cellular crisis exhibit large-scale genomic rearrangements that drive clonal evolution a
Externí odkaz:
https://doaj.org/article/74ca282653444cada7d066278696395b
Autor:
Kevin Norris, Mark J. Ponsford, Tom Vulliamy, Inderjeet Dokal, Amanda J. Walne, Jenna Alnajar, Alicia Ellison, Julia W. Grimstead, Kez Cleal, Duncan M. Baird
Publikováno v:
Human Genetics
Telomere biology disorders are complex clinical conditions that arise due to mutations in genes required for telomere maintenance. Telomere length has been utilised as part of the diagnostic work-up of patients with these diseases; here, we have test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8682a77e8c84d1ff11a112aae6e388e7
https://orca.cardiff.ac.uk/id/eprint/137651/7/Norris2021_Article_High-throughputSTELAProvidesAR.pdf
https://orca.cardiff.ac.uk/id/eprint/137651/7/Norris2021_Article_High-throughputSTELAProvidesAR.pdf
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cf93174b1449b124deada7edc52ace
https://orca.cardiff.ac.uk/id/eprint/141789/7/s41467-021-24201-w.pdf
https://orca.cardiff.ac.uk/id/eprint/141789/7/s41467-021-24201-w.pdf
Autor:
Duncan M. Baird, Rosalind M. John, Isabel Garcia-Martin, Samantha M. Garay, Rhiannon E. Jones, Richard Penketh, Julia W. Grimstead
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7458, p 7458 (2021)
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7458, p 7458 (2021)
Background. Depression is a common mood disorder during pregnancy impacting one in every seven women. Children exposed to prenatal depression are more likely to be born at a low birth weight and develop chronic diseases later in life. A proposed hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ee6c35e8157cd39a6ff5327caed865
https://pubmed.ncbi.nlm.nih.gov/34299077
https://pubmed.ncbi.nlm.nih.gov/34299077
Publikováno v:
Nar Cancer
Identifying attributes that distinguish pre-malignant from senescent cells provides opportunities for targeted disease eradication and revival of anti-tumour immunity. We modelled a telomere-driven crisis in four human fibroblast lines, sampling at m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de41a869c60b710c7fb9a53a40d12760
https://pubmed.ncbi.nlm.nih.gov/33447828
https://pubmed.ncbi.nlm.nih.gov/33447828
Autor:
Nicholas Mielke, Thanh Nguyen, Eric A. Hendrickson, Adam J. Harvey, Julia W. Grimstead, Rhiannon E. Jones, Duncan M. Baird, Matthew Mueller
Publikováno v:
Oncotarget
Poly-ADP ribose polymerase 1 (PARP1) is clinically important because of its synthetic lethality with breast cancer allele 1 and 2 mutations, which are causative for inherited breast and ovarian cancers. Biochemically, PARP1 is a single-stranded DNA b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5c2f49e1fdcfa836b800872f1c3569
https://orca.cardiff.ac.uk/id/eprint/117614/7/26201-1014217-3-PB.pdf
https://orca.cardiff.ac.uk/id/eprint/117614/7/26201-1014217-3-PB.pdf