Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Julia U. Sprenger"'
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167974 (2016)
Calcium (Ca2+) and 3',5'-cyclic adenosine monophosphate (cAMP) play a critical role for cardiac excitation-contraction-coupling. Both second messengers are known to interact with each other, for example via Ca2+-dependent modulation of phosphodiester
Externí odkaz:
https://doaj.org/article/e96e2f12833245c5aafa5a5ebf6ef4cc
Autor:
Hannieh Sotoud, Ruwan K. Perera, Konstantina Stathopoulou, Nadja I. Bork, Jean-Pierre David, Torsten Christ, Julia U. Sprenger, Friederike Cuello, Viacheslav O. Nikolaev, Birgit Geertz, Sophie Schobesberger
Publikováno v:
Cellular signalling. 63
P90 ribosomal S6 kinases (RSK) are ubiquitously expressed and regulate responses to neurohumoral stimulation. To study the role of RSK signalling on cardiac myocyte function and protein phosphorylation, pharmacological RSK inhibitors were tested. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd053a00ca669de0a93027c1b89e08d
https://pubmed.ncbi.nlm.nih.gov/31344438
https://pubmed.ncbi.nlm.nih.gov/31344438
Autor:
Julia U. Sprenger, Maja Köhn, Viacheslav O. Nikolaev, Jonas Herting, Yansong Wang, Ali El-Armouche, Samuel Sossalla, Felix Schatter, Gerd Hasenfuss, Thomas H. Fischer, Jörg Eiringhaus, Markus Zabel
Publikováno v:
Basic Research in Cardiology. 114
Increased late sodium current (late INa) is an important arrhythmogenic trigger in cardiac disease. It prolongs cardiac action potential and leads to an increased SR Ca2+ leak. This study investigates the contribution of Ca2+/Calmodulin-dependent kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645932771dff7f314c69b35f01af2a4f
https://doi.org/10.1007/s00395-019-0720-7
https://doi.org/10.1007/s00395-019-0720-7
Autor:
Lina Yao, Julia U. Sprenger, Viacheslav O. Nikolaev, Samuel Sossalla, Thomas H. Fischer, Friedrich A. Schöndube, Peidong Fan, Luiz Belardinelli, Nico Hartmann, Saera Watanabe, Lars S. Maier, Jonas Herting, Fleur E. Mason, Bernhard C. Danner, Gerd Hasenfuss, Aron-Frederik Popov
Publikováno v:
Cardiovascular Research
Aims Enhanced cardiac late Na current (late I Na) and increased sarcoplasmic reticulum (SR)-Ca2+-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late I Na and SR-Ca2+-leak in atrial cardiomyocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66bcd0c3cda8f3a60fbdda8fcb81625
http://europepmc.org/articles/PMC4476413
http://europepmc.org/articles/PMC4476413
Autor:
Kai Schuh, Marco Abesser, Julia H. Steinbrecher, Julia U. Sprenger, Viacheslav O. Nikolaev, Ali El-Armouche, Ruwan K. Perera, Stephan E. Lehnart, Daniela Hübscher
Publikováno v:
Circulation Research. 116:1304-1311
Rationale : Cyclic nucleotides are second messengers that regulate cardiomyocyte function through compartmentalized signaling in discrete subcellular microdomains. However, the role of different microdomains and their changes in cardiac disease are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d300d6352d83431b26b63ee902fe58b
https://doi.org/10.1161/circresaha.116.306082
https://doi.org/10.1161/circresaha.116.306082
Autor:
Stephan E. Lehnart, Konrad R. Götz, Julia U. Sprenger, Michaela Kuhn, Julia Gorelik, Ruwan K. Perera, Jean-Luc Balligand, Viacheslav O. Nikolaev, Julia H. Steinbrecher
Publikováno v:
Circulation Research. 114:1235-1245
Rationale: 3′,5′-Cyclic guanosine monophosphate (cGMP) is an important second messenger that regulates cardiac contractility and protects the heart from hypertrophy. However, because of the lack of real-time imaging techniques, specific subcellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02efe847578248e746be2464d9d38e8
https://doi.org/10.1161/circresaha.114.302437
https://doi.org/10.1161/circresaha.114.302437
Autor:
Julia U. Sprenger, Viacheslav O. Nikolaev, Lars S. Maier, Julia H. Steinbrecher, Gerd Hasenfuss, Ruwan K. Perera, Stephan E. Lehnart
Publikováno v:
Nature Communications. 6
3',5'-cyclic adenosine monophosphate (cAMP) is an ubiquitous second messenger that regulates physiological functions by acting in distinct subcellular microdomains. Although several targeted cAMP biosensors are developed and used in single cells, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e7592f0875ee4631b32d3e41b9c0a9
https://doi.org/10.1038/ncomms7965
https://doi.org/10.1038/ncomms7965
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167974 (2016)
PLoS ONE
PLoS ONE
Calcium (Ca2+) and 3’,5’-cyclic adenosine monophosphate (cAMP) play a critical role for cardiac excitation-contraction-coupling. Both second messengers are known to interact with each other, for example via Ca2+-dependent modulation of phosphodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac3582d6dc269df1d18982c7f2797b3
https://doi.org/10.1371/journal.pone.0167974
https://doi.org/10.1371/journal.pone.0167974
Publikováno v:
Circulation Research. 113
PURPOSE: cAMP is a central regulator of cardiac function and disease. This global second messenger acts in a compartmentalized fashion, and changes in cAMP dynamics are linked to cardiac diseases. In this project, we visualized cAMP signals directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd1573e0fd7a1c9a0fc9a11b661a0c1
https://doi.org/10.1161/res.113.suppl_1.a311
https://doi.org/10.1161/res.113.suppl_1.a311
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 4, Pp 8025-8046 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Cyclic nucleotides cAMP and cGMP are ubiquitous second messengers which regulate myriads of functions in virtually all eukaryotic cells. Their intracellular effects are often mediated via discrete subcellular signaling microdomains. In this review, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fa1cfa4bc6c67628ada3c4c2684ab9
http://resolver.sub.uni-goettingen.de/purl?gs-1/10732
http://resolver.sub.uni-goettingen.de/purl?gs-1/10732
