Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Julia Tigges"'
Autor:
Saskia Galanjuk, Etta Zühr, Arif Dönmez, Deniz Bartsch, Leo Kurian, Julia Tigges, Ellen Fritsche
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3295 (2022)
The evaluation of substances for their potency to induce embryotoxicity is controlled by safety regulations. Test guidelines for reproductive and developmental toxicity rely mainly on animal studies, which make up the majority of animal usage in regu
Externí odkaz:
https://doaj.org/article/8c29c7c3d60644c28b52114a19f66087
Autor:
Laura Nimtz, Julia Hartmann, Julia Tigges, Stefan Masjosthusmann, Martin Schmuck, Eike Keßel, Stephan Theiss, Karl Köhrer, Patrick Petzsch, James Adjaye, Claudia Wigmann, Dagmar Wieczorek, Barbara Hildebrandt, Farina Bendt, Ulrike Hübenthal, Gabriele Brockerhoff, Ellen Fritsche
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Neurotoxicity is mediated by a variety of modes-of-actions leading to disturbance of neuronal function. In order to screen larger numbers of compounds for their neurotoxic potential, in vitro functional neuronal networks (NN) might be helpful tools.
Externí odkaz:
https://doaj.org/article/6ce21a344da041f7ac23989029624edd
Autor:
Maxi Hofrichter, Laura Nimtz, Julia Tigges, Yaschar Kabiri, Friederike Schröter, Brigitte Royer-Pokora, Barbara Hildebrandt, Martin Schmuck, Alexey Epanchintsev, Stephan Theiss, James Adjaye, Jean-Marc Egly, Jean Krutmann, Ellen Fritsche
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 72-82 (2017)
Developmental neurotoxicity (DNT) testing performed in rats is resource-intensive (costs, time, animals) and bears the issue of species extrapolation. Thus, reliable alternative human-based approaches are needed for predicting neurodevelopmental toxi
Externí odkaz:
https://doaj.org/article/98ecb7605fe2410a96b658b6b4f7c456
Autor:
Wolfgang Kaisers, Petra Boukamp, Hans-Jürgen Stark, Holger Schwender, Julia Tigges, Jean Krutmann, Heiner Schaal
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175657 (2017)
Ageing, the progressive functional decline of virtually all tissues, affects numerous living organisms. Main phenotypic alterations of human skin during the ageing process include reduced skin thickness and elasticity which are related to extracellul
Externí odkaz:
https://doaj.org/article/dafb7b89d4054640ba4ecac395aec156
Autor:
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Eliška Kuchovská, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, Edyta Reszka, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Emma Svensk, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Jens Kurreck, Horst Spielmann
Publikováno v:
Alternatives to Laboratory Animals. 50:381-413
The adoption of Directive 2010/63/EU on the protection of animals used for scientific purposes has given a major push to the formation of Three Rs initiatives in the form of centres and platforms. These centres and platforms are dedicated to the so-c
Autor:
Jördis Klose, Lu Li, Melanie Pahl, Farina Bendt, Ulrike Hübenthal, Christian Jüngst, Patrick Petzsch, Astrid Schauss, Karl Köhrer, Ping Chung Leung, Chi Chiu Wang, Katharina Koch, Julia Tigges, Xiaohui Fan, Ellen Fritsche
Publikováno v:
Cell Biology and Toxicology. 39:319-343
Adverse outcome pathways (AOPs) are organized sequences of key events (KEs) that are triggered by a xenobiotic-induced molecular initiating event (MIE) and summit in an adverse outcome (AO) relevant to human or ecological health. The AOP framework ca
Publikováno v:
Neuroforum. 27:201-212
Exposure to environmental pollutants like chemicals or air pollution is major health concern for the human population. Especially the nervous system is a sensitive target for environmental toxins with exposures leading to life stage-dependent neuroto
Autor:
Adrian Covaci, Julia Tigges, Mamta Behl, Marcel Leist, Stefan Masjosthusmann, Hagen Eike Keßel, Lynn-Christin Stürzl, Ulrike Hübenthal, Andrea Rossi, Melanie Pahl, Jördis Klose, Nils Förster, Jonathan Blum, Katharina Koch, Sabine Schneider, Xenia Dolde, Ellen Fritsche, Farina Bendt, Anna-Katharina Holzer, Kristina Bartmann, Selina Woeste
Publikováno v:
Cell biology and toxicology
Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated diphenyl ethers are banned from the market and replaced by alternative FRs, like organophosphorus FRs, that have mostly unknown toxicological profiles. To study thei
Autor:
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Horst Spielmann
Publikováno v:
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Public awareness and discussion about animal experiments and replacement methods has greatly increased in recent years. The term ‘the Three Rs’, which stands for the Replacement, Reduction and Refinement of animal experiments, is inseparably link
Autor:
Jean Krutmann, Christopher A. Bradfield, Melina Mescher, Jeremiah S. Yee, Dieter Lang, Katharina M. Rolfes, Thomas Haarmann-Stemmann, Anna L. Shen, Christian Vogeley, Julia Tigges
Publikováno v:
Archives of Toxicology. 93:1917-1926
The Toll-like receptor 7 agonist imiquimod (IMQ) is an approved drug for the topical treatment of various skin diseases that, in addition, is currently tested in multiple clinical trials for the immunotherapy of various types of cancers. As all of th