Výsledky vyhledávání - "Julia Stegherr"

Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patients

Autor: Aalbert Schömig, Tanja Morath, Juliane Jaitner, Julia Stegherr, Siegmund Braun, Dirk Sibbing, Adnan Kastrati, Isabell Bernlochner

Publikováno v: Thrombosis and Haemostasis. 105:107-112

SummaryInterindividual response variability to clopidogrel treatment is a well established phenomenon. In recent studies and ongoing large-scale trials where patients with high on-treatment platelet reactivity (HPR) to clopidogrel are being randomise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ab648114517bf779426e7b518284b2
https://doi.org/10.1160/th10-07-0440

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Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement

Autor: Julia Stegherr, Julinda Mehilli, Siegmund Braun, Dirk Sibbing, Albert Schömig, Adnan Kastrati, S. Schulz, N. Von Beckerath, Tanja Morath

Publikováno v: Journal of Thrombosis and Haemostasis. 8:250-256

Summary. Background: In patients undergoing percutaneous coronary intervention (PCI), a link between bleeding and excess mortality has been demonstrated. A potential association of platelet response to clopidogrel and bleeding has not been well estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5e69bb6767be3cc49300d1cce42e54
https://doi.org/10.1111/j.1538-7836.2009.03709.x

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Clopidogrel response status assessed with Multiplate point-of-care analysis and the incidence and timing of stent thrombosis over six months following coronary stenting

Autor: Albert Schömig, Siegmund Braun, Julinda Mehilli, Dirk Sibbing, Wolfgang Vogt, Nicolas von Beckerath, Julia Stegherr, Tanja Morath, Adnan Kastrati

Publikováno v: Thrombosis and Haemostasis. 103:151-159

SummaryClopidogrel low-responsiveness assessed with multiple electrode platelet aggregometry (MEA) has been shown to be a strong and independent predictor of early stent thrombosis (ST) after coronary stenting. The relation of clopidogrel response st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9576437b6404f9399e4e8f169fb1fe3
https://doi.org/10.1160/th09-05-0284

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Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention

Autor: Werner Koch, Dirk Sibbing, Tanja Morath, Katharina Dörrler, Albert Schömig, Adnan Kastrati, Julia Stegherr, Nicolas von Beckerath, Wolfgang Latz, Julinda Mehilli

Publikováno v: European Heart Journal. 30:916-922

Aims Several studies have demonstrated that the mutant *2 allele of the CYP2C19 681G>A loss-of-function polymorphism is associated with diminished metabolization of clopidogrel into its active thiol metabolite and an attenuated platelet response to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876241a5c30daea0cca0c98a22b7a68e
https://doi.org/10.1093/eurheartj/ehp041

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Response to Letter Regarding Article, 'Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement'

Autor: Julia Stegherr, Dirk Sibbing, Werner Koch, Tibor Schuster, Tanja Morath, Siegmund Braun, Nicolas von Beckerath, Albert Schömig, Adnan Kastrati, Daniela Gebhard

Publikováno v: Circulation. 122

Response: We thank Dr Gurbel and colleagues for their comments on our study.1 We agree about the importance of dissecting between the independent contribution of the common *2 and *17 CYP2C19 allelic variants on clopidogrel responsiveness. Whereas ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa89b8be8486cdd9e3cea14766311eb0
https://doi.org/10.1161/circulationaha.110.967158

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Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy

Autor: Daniela Gebhard, Albert Schömig, Adnan Kastrati, Werner Koch, Dirk Sibbing, N. Von Beckerath, Julia Stegherr, Tibor Schuster, Julinda Mehilli, Siegmund Braun, Tanja Morath

Publikováno v: Journal of thrombosis and haemostasis : JTH. 8(8)

Summary. Background: With the cytochrome P450 CYP2C19*2 (*2) allelic variant resulting in complete loss of enzyme function and the CYP2C19*17 (*17) variant being linked to increased transcriptional activity with extensive metabolism of CYP2C19 substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084e71b8c1a40269c6b06357de78bdc6
https://pubmed.ncbi.nlm.nih.gov/20492469

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Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment

Autor: Julinda Mehilli, Tanja Morath, Juliane Jaitner, A Schömig, S. Braun, N. Von Beckerath, Dirk Sibbing, Steven R. Steinhubl, A. Kastrati, Julia Stegherr, Isabell Bernlochner

Publikováno v: Thrombosis and haemostasis. 104(6)

SummaryInflammatory processes in the vessel wall are associated with progression of atherosclerosis and myocardial infarction. Both high levels of C-reactive protein (CRP) and high on-clopidogrel treatment platelet reactivity (HPR) have been linked t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8496c7c33f4bc65e06b68c3b0306c0
https://pubmed.ncbi.nlm.nih.gov/20838744

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Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel

Autor: Albert Schömig, Adnan Kastrati, Nicolas von Beckerath, Nikolaus Sarafoff, Dirk Sibbing, Julia Stegherr, Siegmund Braun, Tanja Morath, Stefanie Schulz, Julinda Mehilli

Publikováno v: European heart journal. 31(10)

Aims A relevant proportion of patients receiving aspirin and clopidogrel after percutaneous coronary intervention (PCI) also require oral anticoagulation with a coumarin derivative such as phenprocoumon. Both clopidogrel and phenprocoumon are metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c54dd68185d8b8975fe1d882e0f0be
https://pubmed.ncbi.nlm.nih.gov/20159881

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Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement

Autor: Daniela Gebhard, Dirk Sibbing, Nicolas von Beckerath, Werner Koch, Siegmund Braun, Adnan Kastrati, Albert Schömig, Tanja Morath, Julia Stegherr, Tibor Schuster

Publikováno v: Circulation. 121(4)

Background— The cytochrome P450 (CYP) 2C19 isoenzyme plays an important role in clopidogrel metabolization. A recently explored CYP2C19 * 17 allelic variant has been linked to increased transcriptional activity, resulting in extensive metabolizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8cf32d218a321a1f1bd822a528a899
https://pubmed.ncbi.nlm.nih.gov/20921447

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A double-blind, randomized study on prevention and existence of a rebound phenomenon of platelets after cessation of clopidogrel treatment

Autor: Adnan Kastrati, Dirk Sibbing, Melchior Seyfarth, Albert Schömig, Julia Stegherr, Stefanie Schulz, Julinda Mehilli, Nicolas von Beckerath, Siegmund Braun

Publikováno v: Journal of the American College of Cardiology. 55(6)

Objectives The goal of this study was to assess whether a platelet rebound exists and whether it can be attenuated by clopidogrel tapering. Background Clinical studies have reported a clustering of thrombotic events after stopping clopidogrel treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847418f989b74999999f1594fe79fbf8
https://pubmed.ncbi.nlm.nih.gov/20152561

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