Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julia Starega-Roslan"'
Autor:
Marcin Bednarek, Marek Trybus, Monika Kolanowska, Mateusz Koziej, Beata Kiec‐Wilk, Artur Dobosz, Marta Kotlarek‐Łysakowska, Anna Kubiak‐Dydo, Ewelina Użarowska‐Gąska, Julia Staręga‐Rosłan, Paweł Gaj, Izabela Górzyńska, Katarzyna Serwan, Michał Świerniak, Adam Kot, Krystian Jażdżewski, Anna Wójcicka
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Background Brachydactylies are a group of inherited conditions, characterized mainly by the presence of shortened fingers and toes. Based on the patients’ phenotypes, brachydactylies have been subdivided into 10 subtypes. In this study, we
Externí odkaz:
https://doaj.org/article/affdf9a585db42bda2bb63ae2877b1ff
Publikováno v:
The Scientific World Journal, Vol 11, Pp 102-117 (2011)
This protocol describes how to perform northern blot analyses to detect microRNAs and their precursors with single-nucleotide resolution, which is crucial for analyzing individual length variants and for evaluating relative quantities of unique micro
Externí odkaz:
https://doaj.org/article/6a69e369596b4516b400e7fd283efb27
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28548 (2011)
One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP. The exact role of
Externí odkaz:
https://doaj.org/article/486873887e894dc59109f9ae253403ff
Autor:
Wlodzimierz J. Krzyzosiak, Adam Ciesiolka, Katarzyna Bilinska, Julia Starega-Roslan, Magdalena Jazurek
Publikováno v:
Nucleic Acids Research
RNA-protein complexes play a central role in the regulation of fundamental cellular processes, such as mRNA splicing, localization, translation and degradation. The misregulation of these interactions can cause a variety of human diseases, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce1722c215c38e7c73b2fc630c235e
http://europepmc.org/articles/PMC5100574
http://europepmc.org/articles/PMC5100574
Publikováno v:
Nucleic Acids Research
The ribonuclease Dicer excises mature miRNAs from a diverse group of precursors (pre-miRNAs), most of which contain various secondary structure motifs in their hairpin stem. In this study, we analyzed Dicer cleavage in hairpin substrates deprived of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586a49d4ffd54a0d26ff568ec6f16fed
https://doi.org/10.1093/nar/gkv968
https://doi.org/10.1093/nar/gkv968
Autor:
Michal Wojciech Szczesniak, Julia Starega-Roslan, Paulina Galka-Marciniak, Marta Olejniczak, Wlodzimierz J. Krzyzosiak, Izabela Makalowska
Publikováno v:
Biochimica et biophysica acta. 1859(4)
shmiRs are pri-miRNA-based RNA interference triggers from which exogenous siRNAs are expressed in cells to silence target genes. These reagents are very promising tools in RNAi in vivo applications due to their good activity profile and lower toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad90706a7543a8ca7f3a5d67dfdb5854
https://pubmed.ncbi.nlm.nih.gov/26921501
https://pubmed.ncbi.nlm.nih.gov/26921501
Publikováno v:
Cellular and Molecular Life Sciences
The human genome contains more than 1,000 microRNA (miRNA) genes, which are transcribed mainly by RNA polymerase II. The canonical pathway of miRNA biogenesis includes the nuclear processing of primary transcripts (pri-miRNAs) by the ribonuclease Dro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5c405db9884e3cc1145063468257da
https://doi.org/10.1007/s00018-011-0726-2
https://doi.org/10.1007/s00018-011-0726-2
Publikováno v:
The Scientific World Journal
The Scientific World Journal, Vol 11, Pp 102-117 (2011)
The Scientific World Journal, Vol 11, Pp 102-117 (2011)
This protocol describes how to perform northern blot analyses to detect microRNAs and their precursors with single-nucleotide resolution, which is crucial for analyzing individual length variants and for evaluating relative quantities of unique micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794a52e5269f47b31bc14a598f72ef3c
https://doi.org/10.1100/tsw.2011.11
https://doi.org/10.1100/tsw.2011.11
Autor:
Piotr Kozlowski, Wlodzimierz J. Krzyzosiak, Krzysztof Sobczak, Edyta Koscianska, Jacek Krol, Wojciech J. Szlachcic, Julia Starega-Roslan
Publikováno v:
Nucleic Acids Research
The biogenesis of human microRNAs (miRNAs) includes two RNA cleavage steps in which the activities of the RNases Drosha and Dicer are involved. miRNAs of diverse lengths are generated from different genes, and miRNAs that are heterogeneous in length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62eb917fd0ea842c6bbbe1001f414017
http://europepmc.org/articles/PMC3017592
http://europepmc.org/articles/PMC3017592
Publikováno v:
International Journal of Molecular Sciences
Volume 16
Issue 4
Pages 8110-8127
International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 8110-8127 (2015)
Volume 16
Issue 4
Pages 8110-8127
International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 8110-8127 (2015)
The deep-sequencing of small RNAs has revealed that different numbers and proportions of miRNA variants called isomiRs are formed from single miRNA genes and that this effect is attributable mainly to imprecise cleavage by Drosha and Dicer. Factors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d239af850a24d3d705b2630931be421