Micropatterning neuronal networks

Autor: Sarah Waide, Peter Jacob, Dirk Janasek, Christoph van Thriel, Nicole Schöbel, Jonathan West, Julia Sisnaiske, Vanessa Hausherr, Heike Hardelauf

Spatially organised neuronal networks have wide reaching applications, including fundamental research, toxicology testing, pharmaceutical screening and the realisation of neuronal implant interfaces. Despite the large number of methods catalogued in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5bea0c57fccc61a4a5979c42877632
https://eprints.soton.ac.uk/375891/

Tri-ortho-cresylphosphate and TCP isomers — Neurotoxic effects in addition to OPIDN?

Autor: Julia Sisnaiske, Christoph van Thriel, Vanessa Hausherr, Nicole Schöbel

Publikováno v: Neurotoxicology and Teratology. 49:103-104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::309b87c0313914cf53dbcf4aca315097
https://doi.org/10.1016/j.ntt.2015.04.018

Microfluidic construction of minimalistic neuronal co-cultures

Autor: Jean-Michel Peyrin, Jonathan West, Julia Sisnaiske, Jenny Baumann, Ya-Yu Chiang, Jean-Philippe Frimat, Sarah Waide, Heike Hardelauf, Emily L. Jackson, Christoph van Thriel, Dirk Janasek, Ngoc-Duy Dinh

Publikováno v: Lab on a Chip
Lab on a Chip, 2013, 13 (7), pp.1402-1412. ⟨10.1039/c3lc41224e⟩
Lab on a Chip, Royal Society of Chemistry, 2013, 13 (7), pp.1402-1412. ⟨10.1039/c3lc41224e⟩

International audience; In this paper we present compartmentalized neuron arraying (CNA) microfluidic circuits for the preparation of neuronal networks using minimal cellular inputs (10-100-fold less than existing systems). The approach combines the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540f8438280b74559218693d12c13d86
https://hal.science/hal-01542866

In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens

Autor: Alfonso Lampen, Julia Sisnaiske, Axel Oberemm, Hans Mielke, Georgia Guenther, Heidrun Ellinger-Ziegelbauer, Raymond Reif, Ahmed Ghallab, Markus Schug, Ursula Gundert-Remy, Birte Hellwig, D. Storm, Jörg Rahnenführer, Patricio Godoy, Hans-Jürgen Ahr, T. Heise, Jan G. Hengstler

Publikováno v: Current Medicinal Chemistry
Current Medicinal Chemistry; Vol 19

Although cultivated hepatocytes are widely used in the studies of drug metabolism, their application in toxicogenomics is considered as problematic, because previous studies have reported only little overlap between chemically induced gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffd98c41bc525fe3f3b6b7f83a65a98
https://pubmed.ncbi.nlm.nih.gov/22414088

High fidelity neuronal networks formed by plasma masking with a bilayer membrane: analysis of neurodegenerative and neuroprotective processes

Autor: Ulrich Marggraf, Christoph van Thriel, Jean-Philippe Frimat, Jan G. Hengstler, Amir Ali Taghipour-Anvari, Evelyn Drabiniok, Heike Hardelauf, Peter Jacob, Andreas Neyer, Jonathan West, Julia Sisnaiske

Publikováno v: Lab on a Chip; Vol 11
Lab on a chip, 11(16), 2763-2771. Royal Society of Chemistry
Lab on a Chip

Spatially defined neuronal networks have great potential to be used in a wide spectrum of neurobiology assays. We present an original technique for the precise and reproducible formation of neuronal networks. A PDMS membrane comprising through-holes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1888ce181667efe03e929c8c334e93b9
https://doi.org/10.1039/c1lc20257j