Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Julia Scheffel"'
Autor:
Hubert Schwarz, Joaquín Gomis‐Fons, Madelène Isaksson, Julia Scheffel, Niklas Andersson, Andreas Andersson, Andreas Castan, Anita Solbrand, Sophia Hober, Bernt Nilsson, Veronique Chotteau
Publikováno v:
Biotechnology and Bioengineering. 119:2152-2166
In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid-sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density perfusion cultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc160430ba9f108bb594cc74229e33d
https://doi.org/10.1002/bit.28120
https://doi.org/10.1002/bit.28120
Autor:
Malin Jönsson, Julia Scheffel, Emma Larsson, Marit Möller, Gabriella Rossi, Magnus Lundqvist, Johan Rockberg, Mathias Uhlén, Hanna Tegel, Sara Kanje, Sophia Hober
Publikováno v:
New biotechnology. 72
Protein activity regulated by interactions with metal ions can be utilized for many different purposes, including biological therapies and bioprocessing, among others. Calcium ions are known to interact with the frequently occurring EF-hand motif, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98177a3615a0478cc67c11a190f7d9d
https://pubmed.ncbi.nlm.nih.gov/36450334
https://pubmed.ncbi.nlm.nih.gov/36450334
Publikováno v:
mAbs
As reported here, we developed and optimized a purification matrix based on a Protein A-derived domain, ZCa, displaying calcium-dependent antibody binding. It provides an alternative to the acidic elution conditions of conventional Protein A affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc576a4dde311af36a696153af930e7e
https://doi.org/10.1080/19420862.2019.1662690
https://doi.org/10.1080/19420862.2019.1662690
Autor:
Julia Scheffel, Sophia Hober
Publikováno v:
Journal of chromatography. A. 1637
The manufacturability of therapeutic monoclonal antibodies is limited by the harsh conditions that antibodies are subjected to during the purification procedure, which in turn restricts the development of novel acid-sensitive antibodies. The gold sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7a84bf5ed54b63c8781f9cb7de7e63
https://pubmed.ncbi.nlm.nih.gov/33412291
https://pubmed.ncbi.nlm.nih.gov/33412291
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607749
Therapeutic antibodies are at the forefront of modern medicine where high purity, which is typically obtained by Protein A-based affinity purification, is of utmost importance. In this chapter, we present a method for neutral and selective purificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9053fa7bb173ac36005af50af520db05
https://doi.org/10.1007/978-1-0716-0775-6_17
https://doi.org/10.1007/978-1-0716-0775-6_17
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2178
Therapeutic antibodies are at the forefront of modern medicine where high purity, which is typically obtained by Protein A-based affinity purification, is of utmost importance. In this chapter, we present a method for neutral and selective purificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41be7b0584fc5136f99c8f1c91e2566e
https://pubmed.ncbi.nlm.nih.gov/33128754
https://pubmed.ncbi.nlm.nih.gov/33128754
In industrial scale downstream processing of antibodies and Fc-fusion proteins, Protein A chromatography is the most commonly used purification method. As the treatments for many severe diseases shift toward biological drugs, in particular antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54747c45311733a6639289e1e6f0b64e
https://doi.org/10.1016/b978-0-08-103019-6.00002-3
https://doi.org/10.1016/b978-0-08-103019-6.00002-3
Autor:
John P. Amara, David M. Bohonak, Benjamin Cacace, Mike Collins, Brandon Coyle, Paul W. Genest, Mirna González-González, Elizabeth M. Goodrich, Elina Gousseinov, Akshat Gupta, Sophia Hober, Sara Kanje, Aydin Kavara, Kelley Kearns, John F. Kelly, Warren Kett, Karol Lacki, Yifeng Li, Allan Matte, Karla Mayolo-Deloisa, Anup Mohanty, Johan Nilvebrant, Emily Peterson, Marco Rito-Palomares, Anna C. Robotham, Thomas Scanlon, Julia Scheffel, Mark Schofield, Peter (Keqiang) Shen, David Sokolowski, Ying Wang, Weichang Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1694da13bee88b696de9bdc1e5133d40
https://doi.org/10.1016/b978-0-08-103019-6.01002-x
https://doi.org/10.1016/b978-0-08-103019-6.01002-x
Autor:
Linnéa Strandberg, Jan Mulder, Linn Fagerberg, Wen Zhong, Evelina Sjöstedt, Andreas Hober, Bjørn G. Voldborg, Abdellah Tebani, Peter Thul, Björn Forsström, Devin P. Sullivan, Göran Bergström, David Kotol, Fredrik Pontén, Sara Kanje, Anders Gummesson, Borbala Katona, Sophia Hober, Åsa Sivertsson, Jochen M. Schwenk, Anna Berling, Emil Lindström, Jimmy Vuu, Anne-Sophie Svensson, Jens Nielsen, Burcu Ayoglu, Emma Lundberg, Magdalena Malm, Cecilia Lindskog, Per Oksvold, Tea Dodig-Crnković, Charlotte Stadler, Ragna S. Häussler, Julia Scheffel, Melanie Dannemeyer, Hanna Tegel, Anna-Luisa Volk, Max J. Karlsson, Adil Mardinoglu, Martin Zwahlen, Magnus Lundqvist, Siri Ekblad, Peter Nilsson, Mathias Uhlén, Kalle von Feilitzen, Frida Danielsson, Anna Månberg, Jonathan L. Robinson, Diana Mahdessian, Elisa Pin, Fredrik Edfors, Johan Rockberg, Mun-Gwan Hong
Publikováno v:
Science signaling. 12(609)
The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f229d2aa95b4d40ca2b172cd8066af
https://pubmed.ncbi.nlm.nih.gov/31772123
https://pubmed.ncbi.nlm.nih.gov/31772123