Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Julia S. Zagaroli"'
Autor:
Gengyang Yuan, Darcy R. Tocci, Changning Wang, Stephen J. Haggarty, Zude Chen, Yan Liu, Hao Wang, Amelia G. Langan, Julia S. Zagaroli, Ping Bai, Robin Striar, Yu Lan, Sepideh Afshar, Debasis Patnaik
Publikováno v:
Journal of Medicinal Chemistry. 64:14745-14756
To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38570b8605bfa1284c7fb16eb837d610
https://doi.org/10.1021/acs.jmedchem.1c01323
https://doi.org/10.1021/acs.jmedchem.1c01323
Autor:
Sepideh Afshar, Amelia G. Langan, Julia S. Zagaroli, Darcy R. Tocci, Ping Bai, Changning Wang, Robin Striar, Yan Liu, Yu Lan, Hao Wang, Gengyang Yuan
Publikováno v:
Bioconjugate chemistry. 32(8)
Two tandem bromodomains (BD1 and BD2) of bromodomain and extraterminal domain (BET) family proteins have shown distinct roles in mediating gene transcription and expression. Inhibitors that interact with a specific bromodomain may contribute to a spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd7da80308b116f66abbd91dadb9bdf
https://pubmed.ncbi.nlm.nih.gov/34139120
https://pubmed.ncbi.nlm.nih.gov/34139120
Autor:
Hallie Blevins, Yiming Xu, Robin Striar, Yan Liu, Darcy R. Tocci, Gengyang Yuan, Julia S. Zagaroli, Changning Wang, Amelia G. Langan, Shijun Zhang, Yulong Xu, Yu Lan, Can Zhang
Publikováno v:
Bioorg Med Chem Lett
We report herein the discovery of a positron emission tomography (PET) tracer for the (NOD)-like receptor protein 3 (NLRP3). Our recent medicinal chemistry campaign on developing sulfonamide-based NLRP3 inhibitors led to an analog, 1, with a methoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4912a0978cc63da7e769741a69b4150e
https://pubmed.ncbi.nlm.nih.gov/33418063
https://pubmed.ncbi.nlm.nih.gov/33418063