Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Julia S. Jacobs"'
Autor:
Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S. Jacobs, Markus M. Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J. Rauckhorst, Eric B. Taylor, Andrew W. Norris, Ajit Vikram, Kaikobad Irani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin resistance. Here, we show that deletion of endothelial Sirt1,
Externí odkaz:
https://doaj.org/article/72b47199e1ba4328a43cb9d21627ccbf
Autor:
Ravinder Reddy Gaddam, Young‐Rae Kim, Julia S. Jacobs, Jin‐Young Yoon, Qiuxia Li, Angela Cai, Hamsitha Shankaiahgari, Barry London, Kaikobad Irani, Ajit Vikram
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Background MicroRNAs regulate cardiac hypertrophy development, which precedes and predicts the risk of heart failure. microRNA‐204‐5p (miR‐204) is well expressed in cardiomyocytes, but its role in developing cardiac hypertrophy and cardiac dysf
Externí odkaz:
https://doaj.org/article/c8bea0cb37fd464bbb84ca559afe785c
Autor:
Ajit Vikram, Young-Rae Kim, Santosh Kumar, Qiuxia Li, Modar Kassan, Julia S. Jacobs, Kaikobad Irani
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-20
Externí odkaz:
https://doaj.org/article/c78103dbf37e4cb9a31d886ce4bad07c
Autor:
Ravinder Reddy Gaddam, Karishma Dhuri, Young-Rae Kim, Julia S. Jacobs, Vikas Kumar, Qiuxia Li, Kaikobad Irani, Raman Bahal, Ajit Vikram
Publikováno v:
Journal of Medicinal Chemistry. 65:3332-3342
The blood levels of microRNA-122 (miR-122) is associated with the severity of cardiovascular disorders, and targeting it with efficient and safer miR inhibitors could be a promising approach. Here, we report the generation of a γ-peptide nucleic aci
Autor:
Jin-Young Yoon, Alexander M. Greiner, Julia S. Jacobs, Young-Rae Kim, William Kutschke, Daniel S. Matasic, Ajit Vikram, Ravinder R Gaddam, Haider Mehdi, Kaikobad Irani, Barry London
BackgroundDecreased peak sodium current (INa) and increased late sodium current (INa,L), through the cardiac sodium channel NaV1.5 encoded bySCN5A, cause arrhythmias. Many NaV1.5 post-translational modifications have been reported by us and others. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3c74438d44848f7213cdfb6c722b34a
https://doi.org/10.1101/2022.12.26.521675
https://doi.org/10.1101/2022.12.26.521675
Autor:
Ravinder R Gaddam, Karishma Dhuri, Yung-Rae Kim, Julia S Jacobs, Vikas Kumar, Qiuxia Li, Kaikobad Irani, Raman Bahal, Ajit Vikram
Publikováno v:
Circulation Research. 131
Background: In patients with diabetes, the endothelial function precedes and predicts the risk of cardiovascular disorders. Current treatment approaches fail to decrease unwanted cardiovascular outcomes in these patients. The blood levels of microRNA
Autor:
Ravinder Reddy Gaddam, Kaikobad Irani, Quixia Li, Young-Rae Kim, Mohanad Gabani, Ajit Vikram, Yumi Imai, Julia S. Jacobs, Joseph A. Promes, Akansha Mishra
Publikováno v:
Biochem Biophys Res Commun
MicroRNAs (miRs) are small non-coding RNAs that regulate the target gene expression. A change in miR profile in the pancreatic islets during diabetes is known, and multiple studies have demonstrated that miRs influence the pancreatic β-cell function
Autor:
Modar Kassan, Ravinder Reddy Gaddam, Qiuxia Li, Kaikobad Irani, Santosh Kumar, Julia S. Jacobs, Ajit Vikram, Jing Liu, Young-Rae Kim
Publikováno v:
Am J Physiol Heart Circ Physiol
SUMOylation is a posttranslational modification of lysine residues. Modification of proteins by small ubiquitin-like modifiers (SUMO)1, -2, and -3 can achieve varied, and often unique, physiological and pathological effects. We looked for SUMO2-speci
Autor:
Julia S. Jacobs, Young-Rae Kim, Diana Castañeda, Kaikobad Irani, Karima Ait-Aissa, Mohanad Gabani, Jing Liu, Isabella M. Grumbach, Mohamed Trebak, Olha M. Koval, Modar Kassan, Ajit Vikram
Publikováno v:
Cell Calcium. 80:18-24
MiR-204 is expressed in vascular smooth muscle cells (VSMC). However, its role in VSMC contraction is not known. We determined if miR-204 controls VSMC contractility and blood pressure through regulation of sarcoplasmic reticulum (SR) calcium (Ca2+)
Autor:
Ravinder Reddy Gaddam, Ajit Vikram, Mohanad Gabani, Veronica Peotta Jacobsen, Modar Kassan, Robert D. Roghair, Qiuxia Li, Santosh Kumar, Karishma Dhuri, Young-Rae Kim, Julia S. Jacobs, Raman Bahal, Kaikobad Irani
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
An impaired decline in blood pressure at rest is typical in people with diabetes, reflects endothelial dysfunction, and increases the risk of end-organ damage. Here we report that microRNA-204 (miR-204) promotes endothelial dysfunction and impairment