Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Julia S. El-Sayed Moustafa"'
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Intermittent fasting and time-restricted diets are associated with lower risk biomarkers for cardio-metabolic disease. The shared mechanisms underpinning the similar physiological response to these events is not established, but c
Externí odkaz:
https://doaj.org/article/8c13a716721049c39a2ea2ce723fd89b
Autor:
Antonino Zito, Amy L Roberts, Alessia Visconti, Niccolo' Rossi, Rosa Andres-Ejarque, Stefano Nardone, Julia S El-Sayed Moustafa, Mario Falchi, Kerrin S Small
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010556 (2023)
X-chromosome inactivation (XCI) silences one X in female cells to balance sex-differences in X-dosage. A subset of X-linked genes escape XCI, but the extent to which this phenomenon occurs and how it varies across tissues and in a population is as ye
Externí odkaz:
https://doaj.org/article/c3e0845ba9914d3a8b2f1d204f9deff8
Autor:
Amy L Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S El-Sayed Moustafa, Max Tomlinson, Ruth CE Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire J Steves, Massimo Mangino, Jordana T Bell, Chloe CY Wong, Timothy J Vyse, Kerrin S Small
Publikováno v:
eLife, Vol 11 (2022)
Background: Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases. X chromosome inactivation (XCI) randomly transcriptional
Externí odkaz:
https://doaj.org/article/1635922f8b864948946a20b9484dd51b
Autor:
Amy L Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S El-Sayed Moustafa, Max Tomlinson, Ruth CE Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire J Steves, Massimo Mangino, Jordana T Bell, Chloe CY Wong, Timothy J Vyse, Kerrin S Small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06808cdfd91b989cbf40e92a952191d1
https://doi.org/10.7554/elife.78263.sa2
https://doi.org/10.7554/elife.78263.sa2
Autor:
Julia S. El-Sayed Moustafa, Anne U. Jackson, Sarah M. Brotman, Li Guan, Sergio Villicaña, Amy L. Roberts, Antonino Zito, Lori Bonnycastle, Michael R. Erdos, Narisu Narisu, Heather M. Stringham, Ryan Welch, Tingfen Yan, Timo Lakka, Stephen Parker, Jaakko Tuomilehto, Jeffrey Seow, Carl Graham, Isabella Huettner, Sam Acors, Neophytos Kouphou, Samuel Wadge, Emma L. Duncan, Claire J. Steves, Katie J. Doores, Michael H. Malim, Francis S. Collins, Päivi Pajukanta, Michael Boehnke, Heikki A. Koistinen, Markku Laakso, Mario Falchi, Jordana T. Bell, Laura J. Scott, Karen L. Mohlke, Kerrin S. Small
Background COVID-19 severity varies widely. Although some demographic and cardio-metabolic factors, including age and obesity, are associated with increasing risk of severe illness, the underlying mechanism(s) are uncertain. Subjects/methods In a met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8dc312d4f924b005861eb6f705e43c
http://hdl.handle.net/10138/346665
http://hdl.handle.net/10138/346665
Autor:
Jordana T. Bell, Mark Ide, Claire J. Steves, Julia S. El-Sayed Moustafa, Kerrin S. Small, Yuko Kurushima, Alexessander Couto Alves, Juan Castillo Fernandez, Pei-Chien Tsai, Caroline I. Le Roy, Tim D. Spector, Francis J. Hughes
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Clinical Epigenetics
Kurushima, Y, Tsai, P-C, Castillo-Fernandez, J, Couto Alves, A, El-Sayed Moustafa, J S, Le Roy, C, Ide, M, Hughes, F, Glastonbury, C A, Small, K S, Steves, C J & Bell, J T 2019, ' Epigenetic findings in periodontitis in UK twins : a cross sectional study ', Clinical Epigenetics, vol. 11, no. 1, 27 . https://doi.org/10.1186/s13148-019-0614-4
Clinical Epigenetics
Kurushima, Y, Tsai, P-C, Castillo-Fernandez, J, Couto Alves, A, El-Sayed Moustafa, J S, Le Roy, C, Ide, M, Hughes, F, Glastonbury, C A, Small, K S, Steves, C J & Bell, J T 2019, ' Epigenetic findings in periodontitis in UK twins : a cross sectional study ', Clinical Epigenetics, vol. 11, no. 1, 27 . https://doi.org/10.1186/s13148-019-0614-4
Background Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5a307100e649fa76cc10c384f14eb7
http://link.springer.com/article/10.1186/s13148-019-0614-4
http://link.springer.com/article/10.1186/s13148-019-0614-4
Symptom clusters in COVID-19 : A potential clinical prediction tool from the COVID Symptom Study app
Autor:
Maxim B. Freidin, Thomas Varsavsky, Abubakar Buwe, Amit Joshi, Mario Falchi, Julien Lavigne du Cadet, Long H. Nguyen, David A. Drew, Ruth C. E. Bowyer, Joan Capdevila Pujol, Wenjie Ma, Marc Modat, Claire J. Steves, Cristina Menni, Mary Ni Lochlainn, Karla A. Lee, Alessia Visconti, Chun-Han Lo, Chuan Guo Guo, Sajaysurya Ganesh, Maria F. Gomez, Tim D. Spector, Paul W. Franks, M. Jorge Cardoso, Tove Fall, Mark S. Graham, Julia S. El-Sayed Moustafa, Richard Davies, Benjamin J. Murray, Andrew T. Chan, Carole H. Sudre, Sebastien Ourselin, Jonathan Wolf
Publikováno v:
Science Advances
Longitudinal clustering of symptoms can predict the need for respiratory support in severe COVID-19.
As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whethe
As no one symptom can predict disease severity or the need for dedicated medical support in coronavirus disease 2019 (COVID-19), we asked whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860bcb9867e1877db5b54c3eba1ddab9
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448252
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448252
Autor:
Kerrin S. Small, Alessia Visconti, Niccolo Rossi, Maxim B. Freidin, Julia S. El-Sayed Moustafa, Richard Davies, Jennifer K Quint, Jonathan Wolf, Marc Modat, Sebastien Ourselin, Ben Murray, Mario Falchi, Nicholas S Hopkinson, Anthony A Laverty, Tim D. Spector, Claire J. Steves
Publikováno v:
Thorax
BackgroundThe association between current tobacco smoking, the risk of developing symptomatic COVID-19 and the severity of illness is an important information gap.MethodsUK users of the Zoe COVID-19 Symptom Study app provided baseline data including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968e356310ab3bd147bb29e60dc1d43c
https://pubmed.ncbi.nlm.nih.gov/33653934
https://pubmed.ncbi.nlm.nih.gov/33653934
Autor:
Jordana T. Bell, Tingfen Yan, Narisu Narisu, Ryan P. Welch, Päivi Pajukanta, Mario Falchi, Jaakko Tuomilehto, Karen L. Mohlke, Heikki A. Koistinen, Francis S. Collins, Amy L. Roberts, Lori L. Bonnycastle, Michael R. Erdos, Julia S. El-Sayed Moustafa, Sarah M Brotman, Laura J. Scott, Li Guan, Markku Laakso, Antonino Zito, Michael Boehnke, Sergio Villicaňa, Kerrin S. Small, Anne U. Jackson, Timo A. Lakka, Heather M. Stringham, Stephen C. J. Parker
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
COVID-19 severity has varied widely, with demographic and cardio-metabolic factors increasing risk of severe reactions to SARS-CoV-2 infection, but the underlying mechanisms for this remain uncertain. We investigated phenotypic and genetic factors as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e297e15ee25dd5eeb384b630b6cf02
http://europepmc.org/articles/PMC7430606
http://europepmc.org/articles/PMC7430606
Autor:
Andrew T. Chan, Ruth C. E. Bowyer, Ana M. Valdes, M. Jorge Cardoso, Jonathan Wolf, Pirro G. Hysi, Alessia Visconti, Massimo Mangino, Carole H. Sudre, Long H. Nguyen, Sebastien Ourselin, David A. Drew, Cristina Menni, Tim D. Spector, Maxim B. Freidin, Thomas Varsavsky, Claire J. Steves, Sajaysurya Ganesh, Julia S. El-Sayed Moustafa, Mario Falchi
Publikováno v:
Menni, C, Valdes, A M, Freidin, M B, Sudre, C H, Nguyen, L H, Drew, D A, Ganesh, S, Varsavsky, T, Cardoso, M J, El-Sayed Moustafa, J S, Visconti, A, Hysi, P, Bowyer, R C E, Mangino, M, Falchi, M, Wolf, J, Ourselin, S, Chan, A T, Steves, C J & Spector, T D 2020, ' Real-time tracking of self-reported symptoms to predict potential COVID-19 ', Nature Medicine, vol. 26, no. 7, pp. 1037-1040 . https://doi.org/10.1038/s41591-020-0916-2
Nature Medicine
Nature Medicine
A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8864795a16e4e6288ebef861ed1d411
https://kclpure.kcl.ac.uk/en/publications/01b9b7f3-4f02-43a0-88f5-b65e98130e6d
https://kclpure.kcl.ac.uk/en/publications/01b9b7f3-4f02-43a0-88f5-b65e98130e6d