Výsledky vyhledávání - "Julia Rosenlöcher"

Akademický článek

Applying Acylated Fucose Analogues to Metabolic Glycoengineering

Autor: Julia Rosenlöcher, Verena Böhrsch, Michael Sacharjat, Véronique Blanchard, Christoph Giese, Volker Sandig, Christian P. R. Hackenberger, Stephan Hinderlich

Publikováno v: Bioengineering, Vol 2, Iss 4, Pp 213-234 (2015)

Manipulations of cell surface glycosylation or glycan decoration of selected proteins hold immense potential for exploring structure-activity relations or increasing glycoprotein quality. Metabolic glycoengineering describes the strategy where exogen

Externí odkaz: https://doaj.org/article/b876e37c4dee42e2967b6abfacb50ab4

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Purification and Characterization of Antibodies Directed against the α-Gal Epitope

Autor: Julia Rosenlöcher, Stephan Hinderlich, Andreas Zappe, Guido Kohla, Maria Kristina Parr

Publikováno v: BioChem
Volume 1
Issue 2
Pages 8-97

The α-Gal epitope is an immunogen trisaccharide structure consisting of N-acetylglucosamine (GlcNAc)β1,4-galactose (Gal)α1,3-Gal. It is presented as part of complex-type glycans on glycoproteins or glycolipids on cell surfaces of non-primate mamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b48eb4eb3b4067d487a1e46f3fb23e

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Glyco-engineered HEK 293-F cell lines for the production of therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics

Autor: Christoph Kannicht, Philipp Wiedemann, Markus Krieger, Paul Rennert, Guido Kohla, Julia Rosenlöcher, Anja Brehm, Madeleine Peschke, Rico Uhler, Mathias Hafner, Annegrit Seifried, Ruth Popa-Wagner, Mario Kröning

Publikováno v: Glycobiology. 31(7)

N-glycosylated proteins produced in human embryonic kidney 293 (HEK 293) cells often carry terminal N-acetylgalactosamine (GalNAc) and only low levels of sialylation. On therapeutic proteins, such N-glycans often trigger rapid clearance from the pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b653a62d26f5a02e21c55f27e9fe6f
https://pubmed.ncbi.nlm.nih.gov/33403396

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The human rhabdomyosarcoma cell line TE671 – Towards an innovative production platform for glycosylated biopharmaceuticals

Autor: Stefan O. Reinke, Grit Sandig, Constanze Weilandt, Julia Rosenlöcher, Véronique Blanchard, Stephan Hinderlich

Publikováno v: Protein Expression and Purification. 115:83-94

The market of therapeutic glycoproteins (including coagulation factors, antibodies, cytokines and hormones) is one of the profitable, fast-growing and challenging sectors of the biopharmaceutical industry. Although mammalian cell culture is still exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899778ba6e4d7996775fa76c8945ed4e
https://doi.org/10.1016/j.pep.2015.08.008

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Comparative N-Glycosylation Analysis of the Fc Portions of a Chimeric Human Coagulation Factor VIII and Immunoglobulin G1

Autor: Guido Kohla, Mario Kröning, Christoph Kannicht, Julia Rosenlöcher, Barbara Solecka-Witulska

Publikováno v: Bioengineering
Bioengineering; Volume 4; Issue 2; Pages: 44

Prevention and treatment of bleeding in patients suffering from hemophilia A are inconvenient due to repeated intravenous infusions owing to the short half-life of coagulation factor VIII (FVIII) in circulation. Besides (glyco-)pegylation of the FVII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64f5ed893735664e11cf65e682fa95c
https://pubmed.ncbi.nlm.nih.gov/28952523

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