Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Julia R.C. Nunes"'
Autor:
Julia R.C. Nunes, Conor O’Dwyer, Peyman Ghorbani, Tyler K.T. Smith, Samarth Chauhan, Victoria Robert-Gostlin, Madison D. Girouard, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100564- (2024)
Metabolic programming underpins inflammation and liver macrophage activation in the setting of chronic liver disease. Here, we sought to identify the role of an important metabolic regulator, AMP-activated protein kinase (AMPK), specifically within m
Externí odkaz:
https://doaj.org/article/01ecd99fcd564181b4e72710a742afcc
Autor:
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not
Externí odkaz:
https://doaj.org/article/40cdcc7f6d5742ecbe16d60323de171c
Autor:
Nicholas D. LeBlond, Peyman Ghorbani, Conor O'Dwyer, Nia Ambursley, Julia R.C. Nunes, Tyler K.T. Smith, Natasha A. Trzaskalski, Erin E. Mulvihill, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1697-1706 (2020)
The dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage dynamics and lipid homeostasis, which are important during atherogenesis. Using LysM-Cre to dri
Externí odkaz:
https://doaj.org/article/f36517f379a741489a56e4fcfe0c1791
Autor:
Conor O’Dwyer, Rebecca Yaworski, Sakie Katsumura, Peyman Ghorbani, Kaelan Gobeil Odai, Julia R.C. Nunes, Nicholas D. LeBlond, Sabrin Sanjana, Tyler T.K. Smith, Shauna Han, Kaitlyn D. Margison, Tommy Alain, Masahiro Morita, Morgan D. Fullerton
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 876-889 (2020)
Choline is an essential nutrient and a critical component of the membrane phospholipid phosphatidylcholine (PC), the neurotransmitter acetylcholine, while also contributing to the methylation pathway. In the liver specifically, PC is the major membra
Externí odkaz:
https://doaj.org/article/6f21bd4cf0e644f38c1cf1dba71d17bc
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O'Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. While dozens of preclinical models have been developed to recapitulate stages of MAFLD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ddd5663855abf5b1478529ddeb4f6a0
https://doi.org/10.1152/ajpendo.00124.2023
https://doi.org/10.1152/ajpendo.00124.2023
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O’Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
ObjectiveMetabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. Potential therapeutic targets have been identified and are currently being pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97799496696775ed8d54eaf274a706c2
https://doi.org/10.1101/2023.01.24.524609
https://doi.org/10.1101/2023.01.24.524609
Autor:
Peyman Ghorbani, Sang Yong Kim, Tyler K.T. Smith, Lucía Minarrieta, Marisa K. Kilgour, Maja Ilijevska, Irina Alecu, Shayne A. Snider, Kaitlyn D. Margison, Julia R.C. Nunes, Daniel Woo, Ciara Pember, Conor O’Dwyer, Julie St-Pierre, Steffany A.L. Bennett, Meera G. Nair, Morgan D. Fullerton
Choline is an essential nutrient and in macrophages, mainly supports phosphatidylcholine (PC) synthesis. Cellular uptake and incorporation of choline into PC is critical for LPS-induced macrophage inflammation. Here, we examined choline metabolism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0764d0bfb3645b653937339ae6a24fd
https://doi.org/10.1101/2022.09.30.510305
https://doi.org/10.1101/2022.09.30.510305