Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Julia R Gog"'
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007345 (2019)
HIV-1 replicates via a low-fidelity polymerase with a high mutation rate; strong conservation of individual nucleotides is highly indicative of the presence of critical structural or functional properties. Identifying such conservation can reveal nov
Externí odkaz:
https://doaj.org/article/cb918929c4994360be6f5aab14ef4a11
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195763 (2018)
We present a fast, robust and parsimonious approach to detecting signals in an ordered sequence of numbers. Our motivation is in seeking a suitable method to take a sequence of scores corresponding to properties of positions in virus genomes, and fin
Externí odkaz:
https://doaj.org/article/8c397e40868b46ad8d9e8869e346ffe5
Autor:
Julia R Gog, Sébastien Ballesteros, Cécile Viboud, Lone Simonsen, Ottar N Bjornstad, Jeffrey Shaman, Dennis L Chao, Farid Khan, Bryan T Grenfell
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 6, p e1003635 (2014)
The 2009 H1N1 influenza pandemic provides a unique opportunity for detailed examination of the spatial dynamics of an emerging pathogen. In the US, the pandemic was characterized by substantial geographical heterogeneity: the 2009 spring wave was lim
Externí odkaz:
https://doaj.org/article/7588682227a142d9ad137d93b5dba98b
Autor:
Desmond Z. Lai, Julia R. Gog
Publikováno v:
Mathematical Biosciences and Engineering, Vol 21, Iss 2, Pp 1979-2003 (2024)
In infectious disease models, it is known that mechanisms such as births, seasonality in transmission and pathogen evolution can generate oscillations in infection numbers. We show how waning immunity is also a mechanism that is sufficient on its own
Externí odkaz:
https://doaj.org/article/378f7efe4d8f4c4686ecb90a846dc8b8
Autor:
Helen M Wise, Edward C Hutchinson, Brett W Jagger, Amanda D Stuart, Zi H Kang, Nicole Robb, Louis M Schwartzman, John C Kash, Ervin Fodor, Andrew E Firth, Julia R Gog, Jeffery K Taubenberger, Paul Digard
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1002998 (2012)
Segment 7 of influenza A virus produces up to four mRNAs. Unspliced transcripts encode M1, spliced mRNA2 encodes the M2 ion channel, while protein products from spliced mRNAs 3 and 4 have not previously been identified. The M2 protein plays important
Externí odkaz:
https://doaj.org/article/3bc38a0a2aa347b38bdcccc4ca32f8e7
Quantifying transmission of highly pathogenic and low pathogenicity H7N1 avian influenza in turkeys.
Autor:
Roberto A Saenz, Steve C Essen, Sharon M Brookes, Munir Iqbal, James L N Wood, Bryan T Grenfell, John W McCauley, Ian H Brown, Julia R Gog
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45059 (2012)
Outbreaks of avian influenza in poultry can be devastating, yet many of the basic epidemiological parameters have not been accurately characterised. In 1999-2000 in Northern Italy, outbreaks of H7N1 low pathogenicity avian influenza virus (LPAI) were
Externí odkaz:
https://doaj.org/article/f26eb4149c504da7ba42a4314e5910c7
Autor:
Adam J Kucharski, Julia R Gog
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 10, p e1002741 (2012)
Recent serological studies of seasonal influenza A in humans suggest a striking characteristic profile of immunity against age, which holds across different countries and against different subtypes of influenza. For both H1N1 and H3N2, the proportion
Externí odkaz:
https://doaj.org/article/23f98d8846164b6c9e419fa80d0cb722
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 3, p e1002027 (2011)
The development of modern and affordable sequencing technologies has allowed the study of viral populations to an unprecedented depth. This is of particular interest for the study of within-host RNA viral populations, where variation due to error-pro
Externí odkaz:
https://doaj.org/article/948997612d504417a7e848bf7b3320f7
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Collections of genetic sequences belonging to related organisms contain information on the evolutionary constraints to which the organisms have been subjected. Heavily constrained regions can be investigated to understand their roles in an o
Externí odkaz:
https://doaj.org/article/2e93cd9169904cc5b41eefcb4098098b
Autor:
Ken T.D. Eames, Maria L. Tang, Edward M. Hill, Michael J. Tildesley, Jonathan M. Read, Matt J. Keeling, Julia R. Gog
Publikováno v:
Epidemics, Vol 42, Iss , Pp 100659- (2023)
Universities provide many opportunities for the spread of infectious respiratory illnesses. Students are brought together into close proximity from all across the world and interact with one another in their accommodation, through lectures and small
Externí odkaz:
https://doaj.org/article/4df3530cdfba42d494342186d22d1604