Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Julia R Dorin"'
Autor:
Brian J McHugh, Rongling Wang, Hsin-Ni Li, Paula E Beaumont, Rebekah Kells, Holly Stevens, Lisa Young, Adriano G Rossi, Robert D Gray, Julia R Dorin, Emily L Gwyer Findlay, David Brough, Donald J Davidson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007694 (2019)
Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance defence agains
Externí odkaz:
https://doaj.org/article/b0ced40c6ffd4268b60634efa7b7782e
Autor:
Julia R Dorin
Publikováno v:
Asian Journal of Andrology, Vol 17, Iss 5, Pp 716-719 (2015)
β-defensin peptides are a large family of antimicrobial peptides. Although they kill microbes in vitro and interact with immune cells, the precise role of these genes in vivo remains uncertain. Despite their inducible presence at mucosal surfaces, t
Externí odkaz:
https://doaj.org/article/fa135dec0b91498db5a5f47bb70af7de
Autor:
Fiona Semple, Heather MacPherson, Sheila Webb, Fiona Kilanowski, Laura Lettice, Sarah L McGlasson, Ann P Wheeler, Valerie Chen, Glenn L Millhauser, Lauren Melrose, Donald J Davidson, Julia R Dorin
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005801 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005673.].
Externí odkaz:
https://doaj.org/article/22629890b1184e4cb180d81aabec403d
Autor:
Fiona Semple, Heather MacPherson, Sheila Webb, Fiona Kilanowski, Laura Lettice, Sarah L McGlasson, Ann P Wheeler, Valerie Chen, Glenn L Millhauser, Lauren Melrose, Donald J Davidson, Julia R Dorin
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005673 (2015)
Human β-defensin 3 (hBD3) is a cationic host defence peptide and is part of the innate immune response. HBD3 is present on a highly copy number variable block of six β-defensin genes, and increased copy number is associated with the autoimmune dise
Externí odkaz:
https://doaj.org/article/9377eba321364004bd58cd30a540c911
Autor:
Yu S Zhou, Sheila Webb, Laura Lettice, Steve Tardif, Fiona Kilanowski, Christine Tyrrell, Heather Macpherson, Fiona Semple, Peter Tennant, Tina Baker, Alan Hart, Paul Devenney, Paul Perry, Tracey Davey, Perdita Barran, Chris L Barratt, Julia R Dorin
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003826 (2013)
β-defensin peptides are a family of antimicrobial peptides present at mucosal surfaces, with the main site of expression under normal conditions in the male reproductive tract. Although they kill microbes in vitro and interact with immune cells, the
Externí odkaz:
https://doaj.org/article/74a58e02491542409cbfb6b455ff1d15
A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro
Autor:
Jennifer R. Shelley, Brian J. McHugh, Jimi Wills, Julia R. Dorin, Richard Weller, David J. Clarke, Donald J. Davidson
Publikováno v:
Shelley, J R, Mchugh, B J, Wills, J, Dorin, J R, Weller, R, Clarke, D J & Davidson, D J 2023, ' A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro ', Scientific Reports, vol. 13, no. 1, 2271 . https://doi.org/10.1038/s41598-023-29558-0
The human skin barrier, a biological imperative, is impaired in inflammatory skin diseases such as atopic dermatitis (AD). Staphylococcus aureus is associated with AD lesions and contributes to pathological inflammation and further barrier impairment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d901627954e455306c2b2cb9ebe43b9
https://hdl.handle.net/20.500.11820/e8186d6c-99ce-4123-87d7-021128f2a13a
https://hdl.handle.net/20.500.11820/e8186d6c-99ce-4123-87d7-021128f2a13a
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Shelley, J R, Davidson, D J & Dorin, J R 2020, ' The Dichotomous Responses Driven by β-Defensins ', Frontiers in Immunology, vol. 11 . https://doi.org/10.3389/fimmu.2020.01176
Frontiers in Immunology, Vol 11 (2020)
Shelley, J R, Davidson, D J & Dorin, J R 2020, ' The Dichotomous Responses Driven by β-Defensins ', Frontiers in Immunology, vol. 11 . https://doi.org/10.3389/fimmu.2020.01176
Defensins are short, rapidly evolving, cationic antimicrobial host defence peptides with a repertoire of functions, still incompletely realised, that extends beyond direct microbial killing. They are released or secreted at epithelial surfaces, and i
Autor:
Lorraine Frew, Jane E. Norman, Tina L Baker, Lenka Hrabalkova, Sarah J. Stock, Donald J. Davidson, Sara R van Boeckel, Ashley K Boyle, Brian J. McHugh, Kirsten L. Wilson, Julia R. Dorin, Heather MacPherson
Publikováno v:
Scientific Reports
van Boeckel, S R, Hrabalkova, L, Baker, T L, MacPherson, H, Frew, L, Boyle, A K, McHugh, B J, Wilson, K, Norman, J E, Dorin, J R, Davidson, D J & Stock, S J 2019, ' Cathelicidins and the onset of labour ', Scientific Reports, vol. 9, 7356 . https://doi.org/10.1038/s41598-019-43766-7
Boeckel, S R V, Hrabalkova, L, Baker, T L, MacPherson, H, Frew, L, Boyle, A K, McHugh, B J, Wilson, K, Norman, J E, Dorin, J R, Davidson, D J & Stock, S J 2019, ' Cathelicidins and the Onset of Labour ', Scientific Reports, vol. 9, no. 1, 7356 . https://doi.org/10.1038/s41598-019-43766-7
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
van Boeckel, S R, Hrabalkova, L, Baker, T L, MacPherson, H, Frew, L, Boyle, A K, McHugh, B J, Wilson, K, Norman, J E, Dorin, J R, Davidson, D J & Stock, S J 2019, ' Cathelicidins and the onset of labour ', Scientific Reports, vol. 9, 7356 . https://doi.org/10.1038/s41598-019-43766-7
Boeckel, S R V, Hrabalkova, L, Baker, T L, MacPherson, H, Frew, L, Boyle, A K, McHugh, B J, Wilson, K, Norman, J E, Dorin, J R, Davidson, D J & Stock, S J 2019, ' Cathelicidins and the Onset of Labour ', Scientific Reports, vol. 9, no. 1, 7356 . https://doi.org/10.1038/s41598-019-43766-7
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Preterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and inflammation are frequent antecedents of spontaneous preterm birth. Cathelicidin, an antimicrobial host defence p
Autor:
David Brough, Paula E. Beaumont, Lisa Young, Adriano G. Rossi, Donald J. Davidson, Brian J. McHugh, Holly Stevens, Robert D. Gray, Hsin-Ni Li, Rongling Wang, Rebekah Kells, Emily Gwyer Findlay, Julia R. Dorin
Publikováno v:
Brough, D & et al. 2019, ' Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa ', PL o S Pathogens, vol. 15, no. 4, e1007694 . https://doi.org/10.1371/journal.ppat.1007694
PLoS Pathogens
McHugh, B J, Wang, R, Li, H-N, Beaumont, P E, Kells, R, Stevens, H, Young, L, Rossi, A G, Gray, R D, Dorin, J R, Gwyer Findlay, E L, Brough, D & Davidson, D J 2019, ' Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa ', PLoS Pathogens, vol. 15, no. 4, e1007694 . https://doi.org/10.1371/journal.ppat.1007694
PLoS Pathogens, Vol 15, Iss 4, p e1007694 (2019)
PLoS Pathogens
McHugh, B J, Wang, R, Li, H-N, Beaumont, P E, Kells, R, Stevens, H, Young, L, Rossi, A G, Gray, R D, Dorin, J R, Gwyer Findlay, E L, Brough, D & Davidson, D J 2019, ' Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa ', PLoS Pathogens, vol. 15, no. 4, e1007694 . https://doi.org/10.1371/journal.ppat.1007694
PLoS Pathogens, Vol 15, Iss 4, p e1007694 (2019)
Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance defence agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7c35dc72029842f042b9ab87b04b88
https://www.research.manchester.ac.uk/portal/en/publications/cathelicidin-is-a-fire-alarm-generating-protective-nlrp3dependent-airway-epithelial-cell-inflammatory-responses-during-infection-with-pseudomonas-aeruginosa(dd95f669-db9b-4895-8f73-65662c7d27f7).html
https://www.research.manchester.ac.uk/portal/en/publications/cathelicidin-is-a-fire-alarm-generating-protective-nlrp3dependent-airway-epithelial-cell-inflammatory-responses-during-infection-with-pseudomonas-aeruginosa(dd95f669-db9b-4895-8f73-65662c7d27f7).html
Autor:
Sarah L, McGlasson, Fiona, Semple, Heather, MacPherson, Mohini, Gray, Donald J, Davidson, Julia R, Dorin
Publikováno v:
European Journal of Immunology
Human β‐defensin 3 (hBD3) is a cationic antimicrobial peptide with potent bactericidal activity in vitro. HBD3 is produced in response to pathogen challenge and can modulate immune responses. The amplified recognition of self‐DNA by human plasma