Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Julia R Cushnir"'
Autor:
Juzheng Huang, Stephanie Wakefield, Julia R. Cushnir, Piers R. Boshier, Sacheen Kumar, George B. Hanna
Publikováno v:
Current Analytical Chemistry. 9:584-592
Autor:
Tracey Cooke, I. M. Buck, Laurence Wright, Atul Kotecha, S. Barret Kalindjian, Nigel P Shankley, Julia R Cushnir, Michael John Pether, C. M. R. Low, J G Vinter
Publikováno v:
Journal of Medicinal Chemistry. 48:6790-6802
A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK(2)) receptor antagonist 5 (JB93182), based on features shared with two related series. The technique uses "field points" as s
Autor:
Piers R. Boshier, Julia R. Cushnir, Onn Min Kon, George B. Hanna, Sarah L. Elkin, Vikash Mistry, Sally Curtis, Nandor Marczin
Publikováno v:
The Journal of surgical research. 193(2)
Esophagectomy and gastrectomy are associated with profound metabolic changes and significant postoperative morbidity. The aim of this prospective clinical study was to determine whether breath analysis can offer novel insight into the surgical metabo
Publikováno v:
Rapid Communications in Mass Spectrometry. 10:399-404
Publikováno v:
Analytical chemistry. 84(21)
Gastric content is a complex biofluid within the human stomach which has an important role in digestive processes. It is believed that gastric content may be a contributory factor in the development of upper gastro-intestinal diseases. In this work,
Publikováno v:
Organic Mass Spectrometry. 28:552-558
Human exposure to carcinogenic alkylating agents can lead to the formation of covalently bound adducts in DNA, some of which are excreted in urine as alkylated purines following DNA degradation and repair. Tandem mass spectrometric methods have been
Autor:
Denise Anderson, Alan G. F. Brooks, Yuk-Sim Tang, Stephen Naylor, John H. Lamb, Peter B. Farmer, E. A. Bailey, Ovnair Sepai, Julia R. Cushnir
Publikováno v:
Environmental Health Perspectives
Scopus-Elsevier
Scopus-Elsevier
Monitoring exposure to alkylating agents may be achieved by quantitatively determining the adduct levels formed with nucleic acids and/or proteins. One of the most significant results arising from the application of this approach has been the discove
Publikováno v:
Rapid Communications in Mass Spectrometry. 4:426-431
Humans are exposed to a large number of carcinogens which may react at various sites throughout the body, including the N-7-, N2-, and O6-positions of guanine. The effects of this are various but may result in depurination and eventual excretion of t
Autor:
Peter B. Farmer, John H. Lamb, Julia R. Cushnir, Nigel A. Brown, Philip E. Mirkes, Stephen Naylor
Publikováno v:
Rapid Communications in Mass Spectrometry. 4:410-414
The reaction pathway of alkylating agents is often exploited in the design of bifunctional anti-cancer drugs. These drugs form mono-DNA adducts as well as inter- and intra-strand cross-linked adducts, notably by reaction at DNA bases, including the N
Autor:
George B. Hanna, Piers R. Boshier, Vikash Mistry, Alison Knaggs, Patrik Španěl, David Smith, Julia R. Cushnir
Publikováno v:
The Analyst. 136:3233
A study is described of the first on line, real time analyses of the exhaled breath of five anaesthetized patients during the complete perioperative periods of laparoscopic surgery. These breath analyses were achieved using a selected ion flow tube,