Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Julia Poletto"'
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Akademický článek
Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles
Autor: Prof. Fernanda Andreia Rosa, Samara Mendes de Souza Melo, Dr. Karlos Eduardo Pianoski, Julia Poletto, Mariellen Guilherme dosSantos, Dr. Michael Jackson Vieira da Silva, Dr. Danielle Lazarin‐Bidóia, Dr. Hélito Volpato, Prof. Sidnei Moura, Prof. Celso Vataru Nakamura
Publikováno v: ChemistryOpen, Vol 10, Iss 10, Pp 931-938 (2021)
Abstract A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases lei
Externí odkaz: https://doaj.org/article/239afcbf39dd485eb5b702be69eab4d1
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3
Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles
Autor: Mariellen Guilherme dos Santos, Celso Vataru Nakamura, Karlos Eduardo Pianoski, Julia Poletto, Samara Mendes de Souza Melo, Sidnei Moura, Michael J. V. da Silva, Danielle Lazarin-Bidóia, Fernanda A. Rosa, Hélito Volpato
Publikováno v: ChemistryOpen
ChemistryOpen, Vol 10, Iss 10, Pp 931-938 (2021)
ChemistryOpen, Vol 10, Iss 10, Pp 930-930 (2021)
A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce4f683984e743c29b1ecad2e5fee68
https://doi.org/10.1002/open.202100141
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4
Antiparasitic activities of novel pyrimidine N ‐acylhydrazone hybrids
Autor: Danielle Lazarin Bidóia, Celso Vataru Nakamura, Julia Poletto, Michael J. V. da Silva, Andrey P. Jacomini, Fernanda A. Rosa, Hélito Volpato
Publikováno v: Drug Development Research. 82:230-240
In this article, a series of 29 new pyrimidine N-acylhydrazone hybrids were synthesized and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi protozoa that cause the neglected diseases cutaneous leishmaniasis and Chagas disease,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3fd1439fd02e38ba38fc6ef1f61aa9
https://doi.org/10.1002/ddr.21745
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One-Pot Highly Regioselective Synthesis of α-Ketoamide N-Arylpyrazoles from Secondary β-Enamino Diketones
Autor: Sidnei Moura, Fernanda A. Rosa, Julia Poletto, Michael J. V. da Silva, Davi F. Back, Andrey P. Jacomini, Gessica M. Ribeiro, Ernani A. Basso
Publikováno v: Organic Letters. 21:6325-6328
An efficient one-pot method is described for the highly regioselective synthesis of α-ketoamide N-arylpyrazoles from secondary β-enamino diketones. For this, the key intermediate, 4-acyl 3,5-dihydroxypyrrolone, was generated in situ and underwent b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0b2cf793ecc1ab3aba983302dce298
https://doi.org/10.1021/acs.orglett.9b02206
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1,2-Addition to trifluoromethylated β-enamino diketones: regioselective synthesis of trifluoromethyl-containing azomethine pyrazoles and isoxazoles
Autor: Jeniffer do Nascimento Ascencio Camargo, Julia Poletto, Fernanda A. Rosa, Karlos Eduardo Pianoski, Michael J. V. da Silva, Andrey P. Jacomini, Sidnei Moura, Davi F. Back, Davana S. Gonçalves
Publikováno v: Organicbiomolecular chemistry. 18(13)
A simple and efficient methodology for highly regioselective synthesis of azomethine pyrazoles and isoxazoles containing a trifluoromethyl group is reported. The cyclocondensation of trifluoromethylated β-enamino diketones (TBED) with phenylhydrazin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce5a041e7a596e546556543eadc735f
https://pubmed.ncbi.nlm.nih.gov/32196053
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7
Front Cover: Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles (ChemistryOpen 10/2021)
Autor: Karlos Eduardo Pianoski, Michael J. V. da Silva, Mariellen Guilherme dos Santos, Julia Poletto, Samara Mendes de Souza Melo, Sidnei Moura, Danielle Lazarin-Bidóia, Fernanda A. Rosa, Hélito Volpato, Celso Vataru Nakamura
Publikováno v: ChemistryOpen
The Front Cover shows the contribution of the SINTHET research group to the synthesis and discovery of new antiprotozoal compounds. The synthetic methodology allowed 60 new diversified isoxazole derivatives with structural variations on the 3‐, 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95531e840c08839319938e5479e1fa3
https://doi.org/10.1002/open.202100214
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8
Discovery of 1,3,4,5-tetrasubstituted pyrazoles as anti-trypanosomatid agents: Identification of alterations in flagellar structure of L. amazonensis
Autor: Julia Poletto, Michael J. V. da Silva, Andrey P. Jacomini, Karlos Eduardo Pianoski, Fernanda A. Rosa, Hélito Volpato, Danielle Lazarin-Bidóia, Celso Vataru Nakamura, Davana S. Gonçalves
Publikováno v: Bioorganic Chemistry. 114:105082
Trypanosoma cruzi and Leishmania species are causative agents of Chagas disease and Leishmaniasis, respectively, known as Neglected Tropical Diseases. Up to now, the treatments are inadequate and based on old drugs. Thus, we report herein the discove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730c1919f4f6707d21e202f4881b2024
https://doi.org/10.1016/j.bioorg.2021.105082
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9
Unconventional Method for Synthesis of 3-Carboxyethyl-4-formyl(hydroxy)-5-aryl-N-arylpyrazoles
Autor: Julia Poletto, Michael J. V. da Silva, Andrey P. Jacomini, Karlos Eduardo Pianoski, Samara Mendes de Souza Melo, Davi F. Back, Fernanda A. Rosa, Sidnei Moura, Gessica M. Ribeiro, Davana S. Gonçalves
Publikováno v: The Journal of Organic Chemistry. 82:12590-12602
An alternative highly regioselective synthetic method for the preparation of 3,5-disubstituted 4-formyl-N-arylpyrazoles in a one-pot procedure is reported. The methodology developed was based on the regiochemical control of the cyclocondensation reac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e4a7b1427002f22d0a52e7f6f2bd59
https://doi.org/10.1021/acs.joc.7b02361
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10
Potential Antileishmanial Activity of 4-N-Acylhydrazone Pyrazolo[3,4-d]pyridazin-7-ones: Synthesis, in vitro Biological Evaluations and Computational Studies
Autor: Maria Helena Sarragiotto, Julia Poletto, Gessica M. Ribeiro, Danielle Lazarin Bidóia, Fávero Reisdorfer Paula, Michael J. V. da Silva, Andrey P. Jacomini, Jéssica T.C. Yokoyama, Celso Vataru Nakamura, Fernanda A. Rosa
Publikováno v: Journal of the Brazilian Chemical Society v.29 n.12 2018
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 29, Issue: 12, Pages: 2657-2668, Published: DEC 2018
In this work a series of 28 novel pyrazolo[3,4-d]pyridazin-7-ones were synthesized and tested against Leishmania amazonensis (strain WHOM/BR/75/JOSEFA) in promastigote and axenic amastigote forms. Five compounds were active against both cellular form
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f85efef79eb22cdb08f11d9c2fe8f90
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018001202657
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