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of 3
pro vyhledávání: '"Julia Piskunova"'
Publikováno v:
Molecular Microbiology. 104:463-471
Microcin C (McC) is a peptide-nucleotide antibiotic that inhibits aspartyl-tRNA synthetase. Here, we show that McC is a strong inducer of persistence in Escherichia coli. Persistence induced by McC is mediated by (p)ppGpp and requires chromosomally e
Autor:
Dmitry Ghilarov, Anthony Maxwell, Konstantin Severinov, Dmitrii Y. Travin, Marina V. Serebryakova, Julia Piskunova, Clare E. M. Stevenson, David M. Lawson
Publikováno v:
Molecular Cell
Summary The introduction of azole heterocycles into a peptide backbone is the principal step in the biosynthesis of numerous compounds with therapeutic potential. One of them is microcin B17, a bacterial topoisomerase inhibitor whose activity depends
Autor:
Darya Tsibulskaya, Svetlana Dubiley, Julia Piskunova, Olga Mokina, Konstantin Severinov, Marina V. Serebryakova, Alexey Kulikovsky
Publikováno v:
Journal of the American Chemical Society. 139(45)
Microcin C is a heptapeptide-adenylate antibiotic produced by some strains of Escherichia coli. Its peptide part is responsible for facilitated transport inside sensitive cells where it is proteolyzed with release of a toxic warhead-a nonhydrolyzable