Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells

Autor: Sergey Sennikov, Marina Volynets, Saleh Alrhmoun, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Marina Fisher, Julia Lopatnikova, Julia Shevchenko, Kirill Nazarov, Julia Philippova, Alaa Alsalloum, Vasily Kurilin, Alexander Silkov

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionAdoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested against a variety of blood neoplasms but is yet to be deeply tested against solid

Externí odkaz: https://doaj.org/article/433d45dbd46f482299d490a3b9a17848

TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors

Autor: Alaa Alsalloum, Saleh Alrhmoun, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Julia Lopatnikova, Vasily Kurilin, Marina Volynets, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov

Publikováno v: Biomedicines, Vol 11, Iss 10, p 2805 (2023)

Adoptive T-cell therapies tailored for the treatment of solid tumors encounter intricate challenges, necessitating the meticulous selection of specific target antigens and the engineering of highly specific T-cell receptors (TCRs). This study delves

Externí odkaz: https://doaj.org/article/5093cd9ee41b46dc9ecc720514ddf6c1

Exploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4.

Autor: Alsalloum, Alaa^1,2 (AUTHOR) alaa.alsalloum19996@gmail.com, Shevchenko, Julia¹ (AUTHOR) shevchenkoja2023@yandex.ru, Fisher, Marina¹ (AUTHOR) msolshanova@gmail.com, Philippova, Julia¹ (AUTHOR) airyuka@mail.ru, Perik-Zavodskii, Roman¹ (AUTHOR) zavodskii.1448@gmail.com, Perik-Zavodskaia, Olga¹ (AUTHOR) perik.zavodskaia@gmail.com, Alrhmoun, Saleh^1,2 (AUTHOR) saleh.alrhmoun1@gmail.com, Lopatnikova, Julia¹ (AUTHOR) lopatnikova18@yandex.ru, Vasily, Kurilin¹ (AUTHOR) vkurilin@niikim.ru, Volynets, Marina^1,2 (AUTHOR) mrsmarinavolynets@gmail.com, Zavjalov, Evgenii^1,3 (AUTHOR) zavjalov@bionet.nsc.ru, Solovjeva, Olga^1,3 (AUTHOR) solovieva@bionet.nsc.ru, Akahori, Yasushi⁴ (AUTHOR) yakahori@med.mie-u.ac.jp, Shiku, Hiroshi⁴ (AUTHOR), Silkov, Alexander¹ (AUTHOR) silkov@niikim.ru, Sennikov, Sergey^1,5 (AUTHOR) sennikovsv@gmail.com

Publikováno v: International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 20, p15134. 20p.

GD2-targeting therapy: a comparative analysis of approaches and promising directions.

Autor: Philippova, Julia, Shevchenko, Julia, Sennikov, Sergey

Publikováno v: Frontiers in Immunology; 2024, p1-27, 27p

Data on Engineered Lymphocytes Published by Researchers at Federal State Budgetary Scientific Institution (TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors).

Publikováno v: Cancer Gene Therapy Week; 11/16/2023, p80-80, 1p